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u/Salt-Orange-189

r/cfs r/HistamineIntolerance r/LongCovidWarriors r/newzealand r/MCAS r/Encephalitis r/pericarditis r/VaxRecoveryGroup r/LowDoseNaltrexone r/aotearoa r/LongCovid
▲ 5 r/LongCovidWarriors

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure

Discussion: [Dr. Wafik El-Deiry: Rising Cancers, Spike Protein Controversies, & the Fight for Scientific Truth](https://youtu.be/Ci593a4IeyU)

Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure

Research indicates that the SARS-CoV-2 spike protein can interfere with the body's natural tumor-suppression mechanisms.
Specifically, when the spike protein is introduced into cancer cells, it disrupts the normal interaction between the p53 protein—often called the "guardian of the genome"—and MDM2, a protein that regulates p53 levels.
Under normal conditions, p53 acts to stop the growth of damaged cells or trigger their death when they become cancerous.

The presence of the SARS-CoV-2 spike protein suppresses the ability of p53 to activate essential genes, such as p21 (WAF1), TRAIL Death Receptor DR5, and MDM2, which are responsible for stopping cell division and inducing cell death. Consequently, when these cancer cells are treated with chemotherapy, the spike protein appears to increase the survival and viability of the cancer cells by blunting the p53-dependent response to DNA damage.
This suggests that the spike protein may alter how cells sense and repair DNA damage, potentially impacting the effectiveness of cancer treatments.

u/Salt-Orange-189 — 9 days ago
▲ 13 r/aotearoa

‘It’s like waking up in another world’ - mysterious illness keeps knocking out teen - Could this be some form of encephalitis?

or KLS

This post is about this news article: https://www.nzherald.co.nz/nz/its-like-waking-up-in-another-world-mysterious-illness-keeps-knocking-out-teen/LSEHZ6GJRBA5PABTXU2C5HDIA4/ where this teenager loses consciousness every three days.

Amelia saying ”It’s like waking up in another world” is almost identical as Allana’s ”It’s like I’m in a dream”.

This teenager’s regular loss of consciousness seems similar to this young woman’s condition, her story starts at 4:30 timestamp https://m.youtube.com/watch?v=ji3PbS9y1Nc&ra=m  Alannah passed away in Aug 2023 from encephalitis.

According to Starship, Encephalitis should be suspected in any child with fever, seizures and decrease in consciousness or irritability. https://www.starship.org.nz/guidelines/encephalitis/ There are seronegative autoimmune encephalitis https://youtu.be/5VwyX30Idcc - a negative lumbar puncture test does not rule it out. It could range from subclinical, chronic, mild/moderate like this https://www.1news.co.nz/2025/11/21/autoimmune-disease-stole-a-mans-memory-heres-how-hes-learning-to-cope/ or this https://youtu.be/HlJSpPpGkjQ to severe. Encephalitis is often misdiagnosed as psychiatric condition https://www.jns-journal.com/article/S0022-510X(19)31306-1/fulltext

Covid infection and vaccination can cause lingering, developing, new symptoms including encephalitis to children and adults.

https://www.instagram.com/reel/DUtJ-I3DnIA/?l=1

https://youtu.be/FU_1kl7KnzU

https://www.ijirms.in/index.php/ijirms/article/view/2090

https://pmc.ncbi.nlm.nih.gov/articles/PMC12214469/.

https://www.auckland.ac.nz/en/news/2021/03/11/scientist-unravels-covid-brain-effects.html

https://pmc.ncbi.nlm.nih.gov/articles/PMC10054808/

FND is just doctors not knowing what to do they blame it on the patient instead.  

u/Salt-Orange-189 — 9 days ago
▲ 7 r/LowDoseNaltrexone

post covid infection/vaccine neurocognitive issues calmed by LDN

Has anyone’s neuro-cognitive/psychiatric conditions from spike protein caused systemic inflammation, mcas etc calmed by LDN and how long did it take?

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u/Salt-Orange-189 — 12 days ago
▲ 3 r/LongCovidWarriors

The paresthesias a precursor to neuropathy

It started with the limbs and head then travelled proximal to the torso - ascending patrathesia. Many of us had the left-side numbness and tingling, then over to chest, eventually crossing to the right side…now both sides. What treatment is there, anybody managed to keep them at bay?

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u/Salt-Orange-189 — 20 days ago
▲ 25 r/MCAS

One reason why Cromolyn sodium may not work for everyone:

“treatment option with cromoglicic acid was avoided due to intolerance to salicylates”

https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2018.00073/full

Edit: Diagnostic blood draw; “extended functional eicosanoid test (FET) determining the release of the eicosanoids leukotrienes and prostaglandines after in vitro exposure to salicylates.“

Prostaglandin D2-supplemented "functional eicosanoid testing and typing" assay with peripheral blood leukocytes as a new tool in the diagnosis of systemic mast cell activation disease: an explorative diagnostic study

u/Salt-Orange-189 — 21 days ago
▲ 7 r/cfs

Feeling groggy in the morning? This is the best time to do the Active Stand Test. Here’s why

In the POTS UK form, they recommend conducting the 10 minute active stand test in the morning.

“…Clinical guidelines and expert organizations, including PoTS UK, emphasize that symptoms are frequently worse in the morning due to physiological changes that occur overnight, such as fluid shifts and relative dehydration.[2]

Because PoTS symptoms often fluctuate throughout the day, performing the active stand test in the morning is recommended to capture the patient's physiological state when they are most symptomatic.[2] During the night, the body is in a horizontal position, which can lead to a decrease in circulating blood volume upon waking.[2] [3] By testing in the morning, clinicians are more likely to observe the characteristic heart rate increase of ≥30beats per minute (or ≥40 beats per minute in adolescents) that defines the syndrome, as the body's compensatory mechanisms are often at their most vulnerable state immediately after rising.[1] [3] [4]

  1. Raj, Satish R. Postural Tachycardia Syndrome: A Concise Guide to Diagnosis and Management. (Print)↩
  2. PoTS: what is postural tachycardia syndrome? BHF Heart Matters↩
  3. Diagnosis. PoTS UK↩
  4. What is POTS? Dysautonomia International↩”

However, in a recent *Post Orthostatic Tachycardia Syndrome: State of the Art Review*, blood flow to the brain is a better indication of POTS

https://www.heartlungcirc.org/article/S1443-9506(25)01654-3/fulltext

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u/Salt-Orange-189 — 30 days ago