Just curious. I have both.

I have MCAS and looking for a gentle way to reduce the histamine creating bacteria. Any suggestions?

I’m a total newbie here experimenting to see if a low histamine diet can help with my symptoms (regular headaches, nasal congestion, throat mucus, always feeling like I’m “allergic to something but can’t figure out what”, random rashes, itching and hives… . I’m wondering if everyone needs to go through and elimination phase to see improvement or if there are people who see improvement just by reducing their intake of high histamine foods.
Analysing my own diet and realized I was eating VERY high histamine every day. Feeling overwhelmed at how to manage it.
I take Allegra daily and have for years, I plan to add quercentin. I tried famotodine but it gave me horrible diarrhea (is there an adjustment period for famotodine? Does that get any better?)

Also should have added I have hashimoto thyroiditis.

Greetings all!

Recently I realized I have some form of histamine intolerance. Never bothered me until I was down with covid couple years back.

My worst symptoms were occasional migraines which I could live with but the worst for me was fatique, light sensitivty, shitty mood, occasional digestive issues but worst was the fatique. I woke up well rested, had some breakfast and bam I wanted to crawl back to bed.

After some experimenting with low histamine diet I had such a relief of said symptoms that I started looking into it more. The more I read the more depressed I was. I starved myself because I was simply overwhelmed.

I was trying to figure out why do I have this intolerance. Then it hit me that my mother has very similar symptoms. She had severe migraines her whole life. 25 days out of a month she had a splitting headache for the past 40 years. I told her about HIT and she switched to low histamine diet. Believe it or not no more headaches. She is absolutely happy and now she cooks all low his foods and enjoys migraine free life.

I on the other hand am even more depressed because it looks like I can eliminate all sources like mold etc can't I?

Is this something hereditary? I heard about hereditary alpha triptasemia. Is MCAS hereditary?

It just feels like I cannot really do anything with it if it's something I inherited.

I would welcome any insight from you here.

Thank you!

I've been working with a functional doctor/dietitian, I have almost been on my elimination diet for five weeks, it has been bland to say the least.
My first two weeks I was still eating some of the wrong foods so it has been dragged out a bit longer than it should have been.

My safe foods have been:
Oats, brown rice, chicken, turkey, salmon, carrot, corn, olive oil, parsley, salt.

I'm ready to start bringing other healthy foods back into my diet, although I need some encouragement to get through the next week.

I bought chicken that was obviously not well handled in butchering because I’ve been in a terrible flare after each time eating it (it was portioned in the freezer between instances so not a leftover problem). Makes me feel so crumby I feel turned off chicken completely now. :(

But when I have a histamine flare I also lose my appetite altogether, despite being hungry. Nothing sounds appetizing at all

What usually sounds and tastes good to you when you feel terrible? Any flare-faves or comfort foods?

Before i started medication ( i cant name here) , i had a brain fog almost constantly. Mostly when at home ( probably mycotoxins, ragweed..) and couple weeks later now i feel better. Brain fog has almost gone, so can focus better on work etc, and i realised that i am surrounded by all toxic people. They suddenly started getting on my nerves, and i finished it off with them. Its like i cant tolerate people’s BS at all. I can see trough them, their selfishness, and i need people who are optimistic, lift you up, cheer you up, not those who are just seeking audience.
Anyone went trough similar thing, that you felt better, and had to change most people around you ?

has anyone had this issue. I took 2 tablets of cetirizine hydrochloride just for one day and literally overnight went from oily skin to completely dry everywhere. Lost the volume under my eye and its like crepey skin now. Face lost volume also and im having fine lines. Also dry eyes and mouth. It's been 3 years and I still haven't recovered?

So I’ve been on this journey this year to find out what the F is up with my body. 2.5 years of physio for chronic pain. Constant illnesses and the rest. Suspected fibromyalgia and polymyalgia.

I had pneumonia in February where I was off sick for a month. Picked up another virus 2 weeks after going back to work (I’m now on virus number 4 and 30+ sick days)…. I was referred to a very thorough resp and allergy specialist at St.George Private in Sydney. Last week to rule out mould.. he did an allergy test and the area for histamine blew up. But… he said nothing to me after about that. I’ve been taking antihistamines nightly since I first saw him in April.

Naively I always thought antihistamines were for environmental things. But that night I went in to a very long winded Google eye opening learning session and realised I ticked off every single symptom and it explained majority of the issues I’ve been facing for years and years. Maybe well over a decade, close to 2.

So I’ve put myself on a low histamine diet as a “let’s see what happens” self investigation. I’ve been sick with said virus since Sunday so can’t report on all symptoms. But…. My face has changed. I’m less puffy. My chronic pain in my shoulder is and neck is almost non existent and I’ve lost over 4kgs!!!!

Im literally gobsmacked! I don’t see the specialist till the end of September, but I’m truly hopeful that I’ll be a completely different person by then! lol

Edit as I forgot the help part.

Snacks for all that is holy. Please give me snack ideas that isn’t a piece of fruit

Hello everyone, I'm currently on a long waiting list for an allergist and the GI so I'm trying to better understand my triggers so I can live my ore comfortably and be proactive until then.

Around January, I started regularly having this unusual experience where I would get flushed, tingly, and warm. My wife says the pores on my face visibly expand. I get a swelling under my tongue and a few times it felt like my throat swelled. I also get a strange sourish metallicish taste in my mouth sometimes.

I've definitely identified citrus and beer as a trigger, but Ive become very skeptical of citric acid as well. I was replacing beer with zevia soda but that ended up making things even worse. I havent had any issues with stevia, so I'm thinking it's the citric acid as I will randomly have flare ups and then I find I unintentionally ate something with citric acid. Smoke flavor may also be a potential trigger.

I can't fully wrap my head around this, which is why I'm seeing specialists. I had an endoscopy recently and I have mild barrets at my zline and i also had a gallstone in this time (had the gallbladder out about a month ago) - so my disgestion is funky all around but this is my big mystery.

Anyone have any similar experience or input?

Hallo zusammen,
ich habe eine diagnostizierte Histaminintoleranz und lebe seit einigen Jahren konsequent histaminarm nach der SIGHI-Liste. Aktuell geht es mir sehr gut. Ich habe nur rund um den Zyklus manchmal noch leichte Symptome.
Ich überlege, mir 4 Tiny Fineline-Tattoos stechen zu lassen (jeweils ca. 1–2 cm, nur schwarze REACH-konforme Farbe).
Mich würden eure persönlichen Erfahrungen interessieren:
Habt ihr euch trotz Histaminintoleranz tätowieren lassen?
Wie war das Stechen und die Heilung?
Hattet ihr einen Histamin-Schub oder andere Beschwerden?
Würdet ihr es wieder machen?
Ich freue mich über jede ehrliche Erfahrung – egal ob positiv oder negativ. Vielen Dank! 😊

For years, when my executive dysfunction got to me, I had the option of a protein shake. The protein shake has betrayed me and now causes heart palpitations, rashes, and GI issues.

What options have worked for you that are either drinkable, microwaveable, or literally grab and go? When I have the energy, I have low prep options, but now on days that I don’t have it in me, I end up just not eating because I have nothing. What are some options that are: microwaveable, grab and go, or drinkable?

Triggers I’ve identified are aged soy (soy sauce), green peppers but not red, and nightshades. Still working on the rest. Gluten and yeast don’t seem to be an issue for me luckily.

I have been so stoked about ready made rice packs. I have been getting them from Sam’s Club for jasmine rice. But maybe whatever is in it is giving me issues. Anyone know if soy lectin is an issue? I can’t find it on the sighi list not sure if it’s that or sunflower oil, anyone know?

Just asking what is the recommended dose to begin NaturDao or NaturDao plus? Can I split the 1million HDU dose. Also which one to take NaturDao or NaturDao plus which has some cofactors thanks

This might get a little long winded, I apologize in advance.

This all started 5 years ago for me. After I quit taking birth control and antidepressants, I started breaking out in hives, and then I started getting chest pains, and I got a little depressed again. I have brain fog and some dietary issues. Mostly when I get take out.

I've been researching the difference between DAO deficiency and HNMT deficiency. I tried a low histamine diet and taking supplements for DAO deficiency, did absolutely nothing for me, and made everything worse. I'm now looking into HNMT deficiency or slow HNMT. On my prenatal labs from my last pregnancy, my vit B was low, specifically B6 and B12. That was a year ago. Before I started looking into HNMT, I had started taking creatine because I'm nearing 30, and I work out a fair bit. It's been a month now on it, and it's made a difference! I'm only taking one zyrtec and pepcid a day when I was taking 2-3. I'm not waking up covered in hives, just a few patches or none at all. I'm still getting chest pains pretty regularly, mood swings, brain fog, and I get flushed. I feel like I'm more in line with the HNMT deficiency/slow HNMT.

I've been told that it sounds like my body can't detox the histamine properly, that my detox pathways are congested. I do believe that to be true, but I think there's other stuff going on. The same person told me I am probably stuck in dysregulation as well.

With all that being said, does anyone have any advice? I'm taking creatine, methylated vit B6 and B12, D3+K2, shilajit, liver support herbs with NAC, zyrtec, and pepcid. What blood panels or other testing should I look into? Can I truly heal from this?

hey guys,

i’m finally making this post because i promised a few months ago to share everything once i’m fully on the other side. after 4-6 years of pure hell – food poisoning in egypt, brutal h2s-sibo, constant skin itching, extreme brain fog, and a histamine barrel that was constantly overflowing – i am finally back to normal. i can eat bread again, my skin is calm, and the drunk feeling in my brain is entirely gone.

here is how it all started and why most standard gut protocols actually made me crash.

1. The Background (How It All Started)

Around 4 years ago, I developed massive symptoms out of nowhere: extreme skin itching, scratching until I bled, red spots all over my body, and unpredictable reactions after eating. I spent over 6 months in Thailand and visited several specialists and advanced "Wellness & Anti-Aging Centers" because normal hospitals couldn't find anything.

• Classic Allergy Tests (blood tests at Bangkok Hospital + Allergy Center): Completely negative, despite my clear physical symptoms.
• IgG4 Sensitivity Test: Showed wheat and garlic were extremely high. I removed gluten long-term, used DPP-IV enzymes, but the root cause was still untouched.

2. The Leaky Gut & Heavy Metal Trap

At a specialized anti-aging center, a deep stool and tox test showed a high aluminum/heavy metal load and severe increased intestinal permeability (Leaky Gut). Basically, particles were leaking into my bloodstream, triggering constant immune reactions, food intolerances, and skin flare-ups.

3. My First Mistake: The Standard "Gut Healing" Overkill

I went on a super strict 100% gluten-free, anti-inflammatory diet for 3–6 months and threw every popular "leaky gut" supplement at my body. My daily routine looked like this:

• Gut Lining: L-Glutamine (5–10g), bone broth, dragon's blood (Sangre de Drago).
• Inflammation: Black seed oil, krill oil, curcumin + piperine, shilajit.
• Gut Flora: Heavy doses of standard probiotics, sauerkraut, kimchi, coconut kefir.
• Antimicrobial & Digestion: Oregano oil, activated charcoal, zeolite, Betaine HCL, apple cider vinegar.

4. The Crash: It Got Significantly Worse

After 2 months of doing this perfectly, my system completely collapsed. I tolerated fewer and fewer foods. Suddenly, tomatoes, fermented foods, and even my long-cooked bone broth triggered insane flushing, anxiety, and full-body itching.

My Realization: I was making a massive mistake. My gut was still highly inflamed, and I started rebuilding it way too early. The bone broth (high histamine), the ferments, the curcumin with piperine (which blocks COMT), and generic probiotic mixes completely overwhelmed my DAO and HNMT enzymes. I created a histamine overload.

5. The Clinical Turning Point: Actual Testing with a Practitioner

The breakthrough happened when I stopped guessing and got real help. My brother is a professional biohacker and naturopath (Heilpraktiker) with his own private practice. We ran deep diagnostics together, including precise breath tests, SIBO, and SIFO stool mapping.

The tests came back positive across the board: a massive hydrogen/methane/H2S expansion and SIFO (Candida spp. positive). Having a practitioner look at the actual gas curves and data instead of just guessing changed everything. We sat down, did a lot of interviews, and targeted the exact antimicrobials needed for my specific curves (for those interested in how the strategy changes based on the breath test results, I added a screenshot from our baseline index to the Google Doc).

6. The Domino Effect

Through those tests, the biological connection became crystal clear:

• Low stomach acid/bile allows bacteria to survive and migrate into the small intestine (SIBO).
• These bacteria produce massive amounts of histamine themselves.
• The inflamed gut lining destroys your DAO enzyme production.
• Result? A completely clogged histamine barrel. You cannot rebuild a gut that is still on fire.

7. How I Finally Fixed It: Raw Data & Exact Strategy

Alongside the SIBO treatment, I bought a cheap 30$ ancestry DNA kit, uploaded the raw data to GeneticGenie, and analyzed my specific genetic bottlenecks with AI. I found out that my body's "methyl-pool" was empty because of a homozygous slow COMT-Rot Gen, a mild MTHFR-Stottern, and a HNMT-histamine block in my brain. My body physically couldn't drain the histamine backlog.

I designed a hyper-precise "bait and kill" strategy for my SIBO, protected my gut against fungal overgrowth with S. Boulardii, fixed my liver-fett-expression (GCKR) by avoiding fructose speed-spikes, and rebuilt my permanent biological shield with very specific histamine-neutral probiotic strains (like B. Infantis and L. Plantarum 299v - avoid standard mixes!).

Since I know exactly how dark, depressing, and hopeless this journey feels, I put my entire exact battle plan, the supplement logic, the timings (break shield -> kill -> trash truck collector), and the exact science into a clean Google Doc for you guys to copy for free.

Here is the full protocol that finally brought my life and focus back: https://drive.google.com/file/d/1yfJpKGeWm3bh4XBtCXp_npT1T11YnuYd/view?usp=sharing

(It includes the exact "bait and ambush" timing with Xifaxan, the herbal killers like Allimax/Neem/Berberine on empty stomach, the biofilm-breakers, and the precise methylation stack with TMG, CDP-Choline, and MTHFR/COMT support).

Everyone's body is unique, so this is just my personal experience and what worked for my specific hardware. But if you’ve been struggling for years and nothing has changed, stop gambling with generic protocols. Look into your raw data, understand your timing, and rebuild your shield.

If you have any questions about the steps, the timing, or your symptoms, just ask below. I’ll try to help as much as I can.

Stay patient, healing takes time but it is 100% possible. Peace. 🦁👊

EDITED:
_____
And yes i dont have any histamine issues anymore

And yes its summarized with AI

EDITED 2:
____

Here are more insights:
The Full 20-Year Timeline (Connecting the Dots: Dandruff, Fatty Liver, and Childhood Stress)

After looking deeper into my medical history with my practitioner brother, we connected all the dots, and it completely blew my mind. Most people think their SIBO/histamine journey started with a sudden food poisoning. For me, Egypt was just the last drop that made a full barrel overflow. Here is the real 20-year timeline of how my body's hardware slowly stalled:

• Dandruff for 17–18 Years (The Early SIFO Signal): Chronic dandruff is mostly caused by Malassezia, a fungal skin organism that is almost always linked to an underlying fungal imbalance in the gut (SIFO). My system was fighting fungal overgrowth under the radar since puberty, long before anyone looked into my gut.
• Fatty Liver Diagnosis: I developed a fatty liver despite never having an alcohol problem and being physically active. The science explains it perfectly: Candida produces toxic byproducts like acetaldehyde and gliotoxin, which are directly hepatotoxic (liver-damaging). Combine that with my genetic raw data showing a homozygous GCKR (++) mutation – which forces the liver to convert any fructose speed-spikes immediately into liver fat (de-novo lipogenesis) – and you have the perfect storm for a fatty liver.
• Family Stress & Bloating Since Childhood (The MMC Killer): Chronic stress and high cortisol during childhood actively suppress the Migrating Motor Complex (MMC) – your gut's internal broom. Because my MMC was never running properly, bacteria and fungi had the perfect, stagnant breeding ground in my small intestine for over a decade.
• Parasite Cleanse with Eczema Flare-ups (The Skin Detox): Years ago, I did a parasite cleanse and got severe eczema as a reaction. Back then, I didn't get it. Now I know: it was a classic Herxheimer die-off reaction. When you kill a massive load of parasites and fungi, the liver and lymphatic system get overwhelmed, and the body forced the toxic waste out through the only alternative escape route it had left – the skin.

Ive never had a histamine issue in my life.

In Europe we just had a heat wave. I am quite sensitive to hot weather and humidity, can even have trouble breathing.

I started having huge histamine reactions, with no previous history.

I am having a little bit of trouble researching this and Im looking for someone with more information/experience in this.

Can a heat wave cause temporary histamine sensitivity?

I am really hoping this isnt a permanent issue for me. Right now I will switch to lower histamine diet to see what happens in a week of low histamine eating.

I usually feel fine until I have that "one food" that suddenly triggers invisible hives, fatigue, blood sugar fluctuations, hunger, anxiousnes...

But since Ive had no history, I cant imagine it would be permanent.