▲ 2 r/MTHFR

Peptides with cyanocobalamin

I have the double mthfr gene mutation and recently prescribed tirzepatide for my autoimmune in a micro dose. The bottle is tirzepatide/glycine/b12 (cyanocobalamin) and dose of 10mg/5mg/500mcg in a 1ml bottle.

I’m doing 5 units to start so that’s 0.5mg tirz/.25mg glycine/25mcg b12.

I know that is like SUUUUCH a minuscule dose but should I be ok with the b12?

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u/Savings_Survey1898 — 13 days ago

Tirz/b12/glycine

Hi! Just prescribed tirz with glycine and b12. Anyone else on this? I have horrible anxiety about starting new medication so I’m just really nervous for side effects. I have Hashimoto’s x4 years and horrible inflammation. 150lbs GW 135. When should I inject? In the morning because of the b12? All advice welcome. 🥹😅
I was told to start at 5 units but even thinking maybe 2.5. It’s a 2ml bottle w/10mg tirz, 5mg glycine and 500mcg of b12 per ml

TIA 💖

reddit.com
u/Savings_Survey1898 — 13 days ago

Newbie advice for hashis

Hi! Just prescribed tirz with glycine and b12. Anyone else on this? I have horrible anxiety about starting new medication so I’m just really nervous for side effects. I have Hashimoto’s and horrible inflammation. 150lbs GW 135. When should I inject? In the morning because of the b12? All advice welcome. 🥹😅
I was told to start at 5 units but even thinking maybe 2.5. It’s a 2ml bottle w/10mg tirz, 5mg glycine and 500mcg of b12 per ml

reddit.com
u/Savings_Survey1898 — 13 days ago

Med change, sos

I’ve been on armour 30 for about 4ish months now. I was on it after my first child was born for a few years and honestly felt great. After this second baby was born I requested to get back on it bc I remember how much I loved it. (They switched me to unithyroid during pregnancy).

Anyways, I feel the absolute worse I’ve ever felt. Debilitating fatigue, muscle weakness, horrible anxiety and depression, list goes on and on. They are switching me to cytomel 5mcg and Tirosint 25mcg to see if this helps.

Looking for some success stories or positive feedback because I’m at the end of my rope. I feel I will always feel this way and I’m scared.

My TSH was only 4.4 (down from 25 initially postpartum).
Free t4 1.06
T3 155
Free t3 3

I think it’s just discouraging because my labs aren’t terrible yet I feel so awful. Any help appreciated 💔

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u/Savings_Survey1898 — 2 months ago

Need some help please

Looking for some advice and just help. I’m at the end of my rope.

Long story short, I got diagnosed with hashis after I had my first child in 2023 (although I think I had it before I just didn’t know). My TSH was 101 and tpos > 900. Put on armor thyroid, went gluten free and did ok for the most part. Fast forward and now also have a 7 month old and i feel the worst i have ever felt. My tsh was 25 at 4m post partum and it’s now 4.4. Free t3 in range on higher side and t4 normal range. They are switching me to liothyrinine and Tirosint to see if this will help because my symptoms for the past two months have been:
Severe fatigue
Extreme anxiety and panic (I’ve been on anti anxiety med for 5 years)
Lots of adrenaline surges
Waking up at 5am racing heart
Dizziness like I’m on a boat
My muscles feel like I’ve ran a marathon when I haven’t done anything. They’re sore and they hurt. I used to workout every single day so this has been the most depressing for me.

I’ve seen every specialist there is and spent so much money on labs and testing.
I did this after my first baby: Rheumatology labs were negative, ANAs were initially positive and then last year were negative. They were dense fine speckled pattern.

Vit d is low but taking drops daily. B12 normal low but I can’t take it because it makes me feel worse. I also have mthfr. Ferritin is low but also taking iron. At this point I’ve convinced myself I also have MS or something else too.

I have no quality of life. I can’t work out, I cry all the time and the only reason I’m still here is because I have two kids relying on me.

Does anyone else feel this way with hashis? I just am at the end of my rope and looking for some reassurance. Does it get better? Will my muscles always hurt? I haven’t started new meds as they’re coming in the mail from cost plus. Didn’t realize it was so expensive at a pharmacy.

reddit.com
u/Savings_Survey1898 — 2 months ago

I need advice, at my end

Long story short, I got diagnosed with hashis after I had my first child in 2023 (although I think I had it before I just didn’t know). My TSH was 101 and tpos > 900. Put on armor thyroid, went gluten free and did ok for the most part. Fast forward and now have a 7 month old and i feel the worst i have ever felt. My tsh was 25 at 4m post partum and it’s now 4.4. Free t3 in range on higher side and t4 normal range. They are switching me to liothyrinine and Tirosint to see if this will help because my symptoms for the past two months have been:
Severe fatigue
Extreme anxiety and panic (I’ve been on anti anxiety med for 5 years)
Lots of adrenaline surges
Waking up at 5am racing heart
Dizziness like I’m on a boat
My muscles feel like I’ve ran a marathon when I haven’t done anything. They’re sore and they hurt.

I’ve seen every specialist there is and spent so much money on labs and testing.
I did this after my first baby: Rheumatology labs were negative, ANAs were initially positive and then last year were negative. They were dense fine speckled pattern.

Vit d is low but taking drops daily. B12 normal low but I can’t take it because it makes me feel worse. I also have mthfr. Ferritin is low but also taking iron. At this point I’ve convinced myself I have MS or something.

I have no quality of life. I can’t work out, I cry all the time and the only reason I’m still here is because I have two kids relying on me.

Does anyone else feel this way with hashis? I just am at the end of my rope and looking for some reassurance. Does it get better? Will my muscles always hurt? I haven’t started new meds as they’re coming in the mail from cost plus. Didn’t realize it was so expensive at a pharmacy.

reddit.com
u/Savings_Survey1898 — 2 months ago