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I’m looking for experiences from people with Hashimoto’s/hypothyroidism who became significantly worse after starting levothyroxine.
My timeline:

10 January 2026: TSH 1.98; ferritin 51; B12 358; vitamin D 71.

19 June 2026: TSH had risen to 7.45, with FT4 13.2. I was experiencing significant fatigue and other symptoms.
9 July 2026: thyroid antibodies came back strongly positive — TPO >400 and TgAb 155, consistent with autoimmune thyroid disease.

July 2026: I started levothyroxine.

Since starting levothyroxine, instead of gradually feeling better, my fatigue has become much worse. I’m now so exhausted that I can be bedridden and sleeping excessively.

9 July: TSH 2.59, FT4 17.6, FT3 4.6.

28 July: TSH 1.63, FT4 16.0, FT3 4.5 — the laboratory reported normal thyroid function.

28 July: reverse T3 400 pmol/L (within the laboratory range).

Despite my thyroid numbers normalising, I feel significantly worse rather than better.
I’m also experiencing extreme skin dryness/dehydration, dull/matte skin and worsening skin symptoms, despite using moisturisers such as QV Intensive Ceramides, hydration, and supplementation of omega 3, 5, 7, krill oil , primrose etc.

I’ve had quite a lot of other testing. My ANA was 1:640, which led to a rheumatology referral, but anti-dsDNA was negative, ENA was negative, C3/C4 were normal, ESR 7 and CRP <3.

I’m trying to understand whether this could be related to levothyroxine, the dose, Hashimoto’s itself, or something else entirely.

Has anyone experienced severe fatigue getting worse after starting levothyroxine even though TSH/FT4/FT3 subsequently became normal?

I am interested in people who became so exhausted they were spending most of their time in bed. Did things eventually improve, or did changing the dose/medication make a difference?

I had my first thyroid ultrasound on **July 8**, which showed **three nodules**:
9 mm
10 mm
**15 mm (1.5 cm)** — the largest
The **ultrasound and biopsy on July 18 were done by the same provider**. Unfortunately, the biopsy was **inconclusive due to not having enough cell samples.**
I then had a **second ultrasound with a different provider on 14th August,** and this time I was told that **the nodules are no longer seen**.
Has anyone experienced thyroid nodules **completely disappearing/not being detected on a follow-up ultrasound**, especially a nodule that was previously measured at **1.5 cm**?
I have **positive thyroid antibodies/Hashimoto’s**, so I’m wondering whether this can happen with thyroiditis, or whether it could simply be differences between ultrasound operators or equipment.
Would love to hear from anyone who has had something similar.
Should I be worried about this?

I had my first thyroid ultrasound on **July 8**, which showed **three nodules**:
9 mm
10 mm
**15 mm (1.5 cm)** — the largest
The **ultrasound and biopsy on July 18 were done by the same provider**. Unfortunately, the biopsy was **inconclusive due to not having enough cell samples.**
I then had a **second ultrasound with a different provider on 14th August,** and this time I was told that **the nodules are no longer seen**.
Has anyone experienced thyroid nodules **completely disappearing/not being detected on a follow-up ultrasound**, especially a nodule that was previously measured at **1.5 cm**?
I have **positive thyroid antibodies/Hashimoto’s**, so I’m wondering whether this can happen with thyroiditis, or whether it could simply be differences between ultrasound operators or equipment.
Would love to hear from anyone who has had something similar.
Should I be worried about this?

I had my first thyroid ultrasound on July 8, which showed three nodules:
9 mm
10 mm
15 mm (1.5 cm) — the largest
The ultrasound and biopsy on July 18 were done by the same provider. Unfortunately, the biopsy was inconclusive due to not having enough cell samples.
I then had a second ultrasound with a different provider on 14th August, and this time I was told that the nodules are no longer seen.
Has anyone experienced thyroid nodules completely disappearing/not being detected on a follow-up ultrasound, especially a nodule that was previously measured at 1.5 cm?
I have positive thyroid antibodies/Hashimoto’s, so I’m wondering whether this can happen with thyroiditis, or whether it could simply be differences between ultrasound operators or equipment.
Would love to hear from anyone who has had something similar.
Should I be worried about this?

Hi everyone,
I’m looking to hear from anyone who has experienced persistent systemic symptoms after hyaluronidase, while also keeping an open mind that there may be an unrelated underlying medical condition.
My health issues started in 2024 with sudden, severe hair loss during an extremely stressful period, so it was initially diagnosed as telogen effluvium. Unfortunately, the hair loss never improved.
I had always tolerated cosmetic treatments well, including lip filler, Profhilo and Botox. In December 2024, I had just 1 mL of cheek filler, but it made my face unusually puffy and reactive. After several months I decided to dissolve it.
In June 2025, I underwent 4–5 ultrasound-guided hyaluronidase sessions using relatively small doses spaced about two weeks apart. I experienced significant swelling after the dissolves, but it eventually settled.
About two weeks after my final dissolve, I had my usual Profhilo treatment followed by Botox. Everything seemed completely normal for another couple of weeks.
Then, around September 2025, almost overnight, everything changed.
Within days my face became extremely dry, and over the following weeks the dryness spread to my entire body. Since then I’ve developed:
Severe whole-body skin dryness that has continued to worsen despite intensive moisturising and barrier repair.
Almost complete loss of sweating.
Hair becoming extremely dry and brittle with ongoing shedding.
Brittle nails with vertical ridges and darker pigmentation.
Dry eyes.
Dry mouth.
Tingling and numbness in my hands.
Burning/prickling sensations in my legs.
I’ve tried numerous barrier-repair products, supplements, collagen, omega-3, oral hyaluronic acid, shorter showers and other supportive measures without any meaningful improvement.
Initially, all my blood tests were normal.
Several months later I was diagnosed with Hashimoto’s thyroiditis after testing showed:
ANA 1:640 homogeneous
Positive TPO antibodies
TSH 7.4
After five weeks of levothyroxine:
TSH normalised to 1.7.
Free T4 and Free T3 are now within range.
Despite this, none of the dryness or neurological symptoms have improved.
My endocrinologist doesn’t think Hashimoto’s alone explains everything and has referred me to a rheumatologist because he suspects Sjögren’s syndrome, although my SSA/Ro, SSB/La, ENA panel and dsDNA are all negative so far.
I’m not saying hyaluronidase caused an autoimmune disease. It may simply be a coincidence in timing, or it may have unmasked an underlying condition that was already developing. I’m still investigating this with my doctors.
I’m mainly curious whether anyone here has experienced:
Persistent whole-body dryness after hyaluronidase.
Loss of sweating.
Dry eyes and dry mouth.
Neuropathy-type symptoms.
Or whether anyone ultimately discovered an autoimmune diagnosis after initially thinking their symptoms were related to hyaluronidase.
I’d really appreciate hearing your experiences while I wait for my rheumatology appointment.

I wanted to share my experience because I spent months believing hypothyroidism was causing everything.
My first symptoms weren’t fatigue—they were my skin, hair and nails.
Around September last year, my skin suddenly became extremely dry and dehydrated. I lost what felt like all of my natural skin oil, moisturiser would disappear into my skin within minutes, my skin became wrinkled, darker and crepey, and I started losing a significant amount of hair. My nails also changed.
As time went on, my skin, hair and nails continued to get progressively worse. I also developed hand neuropathy, gastrointestinal symptoms (bloating and needing to use the bathroom after meals), burning skin, dry eyes and dry mouth. At that stage I didn’t have the debilitating fatigue that I have now.
I had my thyroid tested in January, and my thyroid function was normal:
TSH 1.98 mIU/L
Normal thyroid function according to the lab.
Because my thyroid was normal, I kept looking for other answers while my symptoms continued to worsen.
In June, my blood tests showed:
TSH 7.45 mIU/L
Free T4 13.2 pmol/L
I was later diagnosed with Hashimoto’s, with strongly positive thyroid antibodies.
After starting treatment, my thyroid levels returned to normal:
9 July: TSH 2.59, Free T4 17.6, Free T3 4.6.
Latest: TSH 1.63, Free T4 16.0, Free T3 4.5.
Today I saw an endocrinologist. His opinion was that although I likely have Hashimoto’s thyroiditis, he does not think my skin, hair, nail and other symptoms are due to hypothyroidism, because they started many months before my TSH became elevated and have continued despite my thyroid function now being normal.
I also have:
ANA 1:640 (homogeneous)
Negative ENA screen
Negative dsDNA
Positive thyroid antibodies
He thinks there may be another autoimmune condition, and mentioned Sjögren’s syndrome as one possibility for my rheumatologist to investigate.
I’m posting because I assumed every symptom I had was from hypothyroidism. In my case, my endocrinologist felt the timeline suggested something else may also be going on.
Has anyone else had Hashimoto’s but later found another autoimmune condition was responsible for most of their symptoms?

Hi everyone,
I’m hoping to get some opinions from people who may have experienced something similar while I wait to see a rheumatologist.
My health issues started in 2024 with sudden, severe hair loss. It happened almost overnight during an extremely stressful period, so it was initially diagnosed as telogen effluvium. Unfortunately, the hair loss never improved and actually continued to get worse over time.
I’ve also always been a fan of cosmetic treatments (mainly lip filler, Profhilo and Botox). In December 2024, I had a small amount of cheek filler (1 mL total). It made my face unusually puffy and reactive, so after a lot of consideration I decided to have it dissolved in last year June.
I underwent 4–5 hyaluronidase sessions using small doses, about two weeks apart. I experienced a lot of swelling during the dissolving process, but it eventually settled. About two weeks after my final dissolve, I had my usual Profhilo treatment followed by Botox. Everything seemed completely normal for a couple of weeks.
Then, in September 2025, almost overnight, everything changed.
Within days my face became incredibly dry, and over the following days and weeks the dryness spread to my entire body. Over the next few months I noticed:
- Extremely dry skin over my whole body that continued to worsen despite intensive moisturising and barrier repair.
- I gradually stopped producing sweat almost completely.
- My hair became extremely dry, like straw, and the shedding increased.
- My nails became brittle, darker in colour and developed vertical ridges.
I completely changed my skincare routine, using products like CeraVe, La Roche-Posay, shea butter, petroleum jelly and other barrier-repair products. I shortened showers to 3–4 minutes and started taking omega-3, sea buckthorn oil, evening primrose oil, vitamin D, vitamin C, zinc, silica, collagen and oral hyaluronic acid. None of it made any difference and the dryness continued to progress.
In January 2026, I had routine blood work which was reportedly normal, despite my symptoms continuing to worsen.
In June 2026, I requested additional testing. My results showed:
● TSH: 7.4
● Positive TPO antibodies
● ANA: 1:640 homogeneous
I was diagnosed with Hashimoto’s thyroiditis and started levothyroxine immediately.
Five weeks later:
● TSH was down to 1.7
● Free T3 and Free T4 were within range
I initially thought all of my symptoms were due to hypothyroidism and would improve once my thyroid levels normalised. Unfortunately, they haven’t.
Over the past three months I’ve also developed:
● Dry eyes
● Dry mouth
● Tingling and numbness in my hands
● Prickling/burning sensations in my lower legs and thighs
I recently saw an endocrinologist who reviewed all my results and said he doesn’t think Hashimoto’s alone explains everything. He suspects Sjögren’s syndrome and referred me to a rheumatologist.
Since then I’ve had further autoimmune testing:
● ENA panel (including SSA/Ro and SSB/La) – negative
● Anti-dsDNA – negative
● Lupus antibodies – negative
● Iron (ferritin) 53
● Vitamin D and B12 are both in the optimal range.
I’m now waiting to see a rheumatologist, but I’m wondering if anyone has had a similar experience.
Has anyone been diagnosed with Sjögren’s despite negative SSA/SSB (seronegative Sjögren’s)?
Could Hashimoto’s alone really cause such severe whole-body dryness, loss of sweating, dry eyes, dry mouth and neuropathy-like symptoms, even after thyroid levels have normalised?
I’d really appreciate hearing from anyone who’s experienced something similar or has any insights while I wait for my appointment.