Anyone stop taking Skyrizi? Did your psoriasis come back? Did restarting work again?

I've been on Skyrizi for about 3 years now. My psoriasis has only ever been on my scalp, no joint pain or other areas involved. Curious to hear from others who've paused or stopped it (insurance issues, side effects, wanting a break, etc.).

A few questions:

  • How long were you on it before stopping, and how long did it take for symptoms to return (if they did)?
  • Did the flare come back as bad as before, worse, or milder?
  • If you restarted Skyrizi after a gap, did it work as well as the first time, or did you notice reduced effectiveness?
  • Roughly how long was the gap before you restarted?

Also curious — has anyone tried stretching out the interval between doses instead of stopping completely? Like going from every 12 weeks to 13, then 14, then 15, etc., pushing it out a bit more each time rather than cold-stopping. Did that work okay, or did symptoms creep back once you went past 12 weeks?

Part of why I'm asking: I don't love the idea of being dependent on a medication long-term, and I'm a bit wary of staying on an immunosuppressant as I get older (infection risk, whatever else comes with aging on a drug like this). So I'm trying to figure out if there's a realistic path to less frequent dosing, or if that's just wishful thinking for how this drug works.

Trying to get a sense of what's realistic before I consider changing up my own dosing. Appreciate any experiences you're willing to share.

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u/ghl262 — 11 hours ago

Can N2 present with mild symptoms? Tired all the time but never actually falling asleep?

Hi all,

I was diagnosed with N2 back in 2024 (mean sleep latency 5.1 min, 4 SOREMs on my MSLT — attached), but I’ve honestly been in denial ever since. When I read posts here, people describe symptoms way more severe than mine — falling asleep mid-conversation, unable to drive — and I keep thinking mine don’t measure up.

Why I’ve struggled to accept it:

  1. I originally saw the sleep specialist for sleep-maintenance insomnia, which I assumed was the real cause of my daytime tiredness. I know narcolepsy can cause insomnia, but insomnia can also cause daytime sleepiness — so I couldn’t rule out that the arrow points the other way, or that the test was a false positive.
  2. My symptoms feel milder than what I see here. I got through rigorous schooling and I have a mentally demanding full-time job. I don’t fall asleep talking to people. I’ve dozed off watching TV maybe 30-50 times over my entire life, but I figured that happens to everyone. I get hit hard with sleepiness after lunch, but plenty of people without narcolepsy get a food coma too. My main symptom is that I feel too drained to do anything productive — I just want to play video games or watch YouTube. But when I actually play, I never fall asleep
  3. I tried Xywav, but every med has side effects, and I hate the idea of depending on medication for the rest of my life just to do something as basic as sleep. Part of me keeps asking: if my symptoms are this mild, why not just push through?

What’s slowly changing my mind:

On the other hand, a few things have been nudging me toward accepting it. When I take short naps — even just 10 minutes — I dream. And I dream pretty much every night and remember them. About 5% of the time they’re nightmares, usually someone chasing me or trying to kill me. I’ve also had sleep paralysis since I was young — not constantly, but probably around 100 times over my life. The more I read about how these tie into REM regulation, the harder it is to wave it all off as nothing.

So my questions:

  1. Is sodium oxybate overkill for someone like me?
  2. Is anyone else here on the milder end — tired constantly but rarely actually falling asleep?

Thanks for reading.

u/ghl262 — 6 days ago

Peer pressure and FOMO

35M married with a wife (36F). I’m 70% pro kids, wife is 100% against having kids.

All my close friends have kids now, and I feel jealous. If I lived in a kid-free society, I would be okay with not having kids, but when I see my close friends having kids, I feel FOMO and worry about my kid-free future. I know both ways have pros and cons, and I know having a kid due to FOMO alone is wrong, but this is the reality.

If we had a kid, I’m confident that I will be a good parent. But due to some circumstances, we are not having kids probably. I hope I will be okay in the future and don’t regret too much.

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u/ghl262 — 21 days ago

Hours of sleep on Xywav?

First night of xywav with 2.25 * 2 only gave me 5.5 hrs of sleep, when I usually get 6.5 hrs. I don’t feel refreshed at all as expected. Is this normal? Would it go up to 7-9 hrs as the dosage goes up?

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u/ghl262 — 25 days ago

99% in Stocks, only 1% in Cash

Hi, I’m 35M, double income no kids yet.
Majority of my assets is in stocks, except for my house, so only 1% of my NW is in cash.
Is it too aggressive considering potential AI bubble?
What % of your portfolio is in cash?

u/ghl262 — 25 days ago

Chances of false positive for N2?

I was diagnosed with N2 about 2 years ago, and even got Xywav, but after trying it for a few days, I got scared and stopped. I in general do not like being dependent on medication, and I’m already on an immunosuppressant drug for other health issue.

Should I get a retest for N2? My symptoms are mild compared to others I believe. Sure, I have EDS and brain fog, but I can push through it a lot of times and have a full time job. It is a struggle though often.

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u/ghl262 — 26 days ago

Quitting FC26 after being addicted

I started during TOTS and played like an addict since then. Although I love the fifa game, this game makes it feel too much like a second job - all the daily grind, stress during WL, FOMO, terrible gameplay, input delay, and toxic players (and dumb rush players).

Adios, my friends. I enjoyed it while it lasted. So many other good games are coming out. I will pick FC back up maybe when I’m financially free and have more time to grind, but until then, no more stressful gaming!

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u/ghl262 — 26 days ago

How to get better at this game?

I’m relatively new to the game as I started playing around when TOTS started. How do I get better? I can only win 7 WL consistently, but not a single win more or less.

Those that are really good at the game, any tips for someone like me? Thanks!

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u/ghl262 — 27 days ago

Extreme anger when losing fut cham

How to control anger when losing the game? I normally win around 7, and it’s so frustrating when the game play is so bad and lagging and I lose because of that.

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u/ghl262 — 27 days ago
▲ 1 r/EAFC+1 crossposts

Not Enough Tokens for this week?

There are not enough tokens available to fill 1,000 tokens limit this week. How come? Are they forcing us to swap fodders for tokens?

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u/ghl262 — 29 days ago

Messi - History in Ten

Is this Messi good in CAM or RM?
Controlled pace.

u/ghl262 — 1 month ago

Kanjinga Evo Thoughts?

3 star skill is bad, but everything else solid with lengthy pace too.

u/ghl262 — 1 month ago

Is showdown different for UCL?

Would this card go to 92? Or 93 or 96?
I’m guessing showdown cards go up less than road to final cards right?

u/ghl262 — 1 month ago

This game makes me irrationally mad

I’m normally a calm person, but when I play fut champ, I get so angry at my opponent and for my self for making stupid mistakes.

I recently started playing ultimate mode, and I only played for a month, so I’m late to the game. I can get 7 wins out of 15 games per average, but omg, the opponents make the same exact goals every single time. Through pass, run, and then either finesse or low driven shot every single time. On the other hand, I like passing play, so my goals tend to be different each time.

But damn, this game is sucking the soul out of me.

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u/ghl262 — 1 month ago