What do we expect? Especially considering the Iran war and how hydrogen may have been a cheaper option temporarily for certain goals. Revenue improved, or have investments driven down the revenue? Will Plug thrive on the popularity of AI? Will this momentum keep building?
Even in zebrafish, when strongly crosslinked collagen is created (as is present in old, mature scar tissue, zebrafish seem capable of regressing this tissue and restoring original tissue organization.
this may have implications for mammalian scarring too, potentially opening up avenues to regress scar tissue.
https://www.sciencedirect.com/science/article/pii/S2590006426004370
No biomechanical testing yet, and hyaline cartilage formation needs to be confirmed, but histologically looks promising.
larynx*, by the way. Not dyslexic, just a tiny screen with even tinier keyboard and no patience.
Potentially interesting to restore gliding planes (laser or excise fibrotic adhesions, add a mesh preventing new scar tissue, and perhaps factors helping restore gliding planes.
Also potentially interesting as a way to extend the nose without severe rigidity, especially if scar tissue can be kept at bay, and the skin may regain (hopefully) a more natural draping over the nasal skeleton.
Very impressive! In this case used for heart applications.
https://ieeexplore.ieee.org/abstract/document/10340321
Can help planning nose surgery, and perhaps identify scar tissue for regenerative approaches
For joints currently, but still good!
https://en.sedaily.com/business/2026/06/26/rokit-healthcare-advances-cartilage-kidney-regeneration
https://www.biorxiv.org/content/10.64898/2026.06.18.732512v1
at one point revision surgery or post-trauma surgery may benefit from releasing or lasering scar tissue, followed by this combination of treatments (except the microneedling perhaps), and may allow healing with less scarring, while sutures are still in place for support. may improve skin tissue quality too, and the usage of flexible support systems to get nose shape and squish, since contraction is no longer an issue.
in addition, it makes outcomes way more predictable, which combined with tissue engineering allows for a better restoration of the original nose.
verteporfin and retinoic acid are both available already. verteporfin is FDA approved, and already used off-label to reduce scarring after research by Stanford university showed it allows embryo-like healing patterns (i.e. without scarring).
Could be done with static culture, resulting in good cartilage. Dynamic conditions seem to further improve this. Their methods are reproducible and scalable: important for bringing this to clinic and reducing costs.
This will drive down costs, and since it will be used for joints too, nose cartilage can lift on the success of joint cartilage!
Molecules twist. The ones rotating the right way induce better bone formation in MSCs. Better bone, faster bone. Happier patient.
Not a cure, one would need to keep using it. In addition, it is probably not effective in all patients, because it depends on what causes ENS in you. Still, it's another aid to deal with the symptoms!
61% of patients saw improvement.
Automation, 3D printed bio-reactors, allow easier GMP compliance, and scale-up (24/7 culturing, with less lab personnel).
This is good, because for joint cartilage such labs will come into existence, and adding nasal cartilage in the process is then relatively easy.
Cutting edge tech, and preparations for clinical trials for tissue engineered bone.
This is for joint cartilage, and it's a cell-free scaffold, but it is regenerative medicine. If a great scaffold is designed, it may regenerate cartilage in the nose too (with the right growth factors, nutrients, etc.).
Note how at the top, the septum is wider. Studies like these make it easier to predict what a septum looks like from pre OP pics, particularly regarding the dorsal lines. To properly recreate dorsal lines also under the ULCs (the dorsal lines are formed by the bones and the ULC and septum. But it seems the septum and nasal bony processes are decisive in the middle vault) , it seems a 3D printed dorsal septum extension also needs to mimick the wider dorsal septal shape. Note the small subtle groove in the dorsal T shape! This groove is responsible for the subtle contouring of the nose. No current onlay graft or push-up graft can replicate this, except for maybe INNORIB, if those lines were removed by your surgeon.
The convexity of the dorsum can be restored with push up grafts or dorsal preservation grafts.
Therefore, restoring dorsal lines is possible by creating 3D bone grafts, a dorsal cartilage 3D septum graft (may or may not include parts of the ULCs), and proper positioning of the nasal sidewall processes.
Direct link to the 3D view, for those interested: https://3d.nih.gov/model-viewer?entryId=20598&initialModelId=605216&version=2
note: it is an average septum, so you will not see crookedness or its relation to the turbinates (interesting for ENS)
For further reference, the dorsal contour is created by the bony dorsal sidewalls, and the septum creating the dorsal contour. However when one looks closely, a natural nose often has two small, subtle lines running over the dorsum, the contour of which may in part be created by the groove seen in the widening of the dorsal septum, combined with the spanning of the ULCs between the dorsal bony sidewalls and dorsal septum.