
Olanzapine (aka Zyprexa) May Be Effective for Status Migrainosus
Howdy from one of your new mods!
I have been in status for about a month and my neuro prescribed olanzapine a couple days ago. This inspired me to dig into research a little!
- Problem: status migrainosus, aka a migraine attack lasting more than 72 hours
- Home treatment (initiated when typical oral abortives have failed) can include use of neuroleptics like oral metoclorpamide/reglan or oral steroids; injection or nasal triptans, DHE, or ketoralac/toradol
- ER treatment guidelines suggest IV use of neuroleptics like metoclorpamide/reglan or DHE
- Refractory cases may consider IV depakote and/or nerve blocks
- My neuro office typically uses nerve blocks (occipital and/or SPG) and oral steroid tapers for home care when abortives have failed, preferring to keep you out of the ER if possible
Nerve blocks and steroids have failed me in the past, so my neuro suggested a short course of oral depakote (similar to sodium valproate) or oral olanzapine/zyprexa. I opted for olanzapine since both are sedating but the olanzapine you take at night and the depakote is taken multiple times throughout the day. So my hope is that olanzapine will preserve more daytime functionality.
Here's a recent article I found on olanzapine for status:
Efficacy of Olanzapine as an Abortive Treatment for Status Migrainosus: A Retrospective Chart Review
Published in Neurology, April 2025
- What they did: review hospital records to look at outcomes for individuals who were given olanzapine for status migrainosus. They excluded patients prescribed olanzapine for long-term use or to treat conditions other than status migrainosus
- What olanzapine is: an atypical antipsychotic drug that blocks dopamine and serotonin receptors. Tpyically used to treat bipolar disorder type 1 and schizophrenia
- All together, they had 59 patients who met criteria for the ~3 year period they looked at
- Treatment was effective in 29/42 patients (69%) on 2.5 mg, 10/12 (83%) on 5 mg, and 3/5 (60%) on doses over 5 mg. Overall it was effective in 42/59 (71%) patients -- I am not able to access the full text to see, but I presume this was delivered by IV
So: small observational study, I would give it less weight than a double-blinded, controlled study, but the results are encouraging. It's too soon to tell if it's working for me (25mg 1x daily for 3 days) but I'll update to report. The office protocol can include increasing the dose as high as 75mg if needed to manage attacks and for up to 5 days if needed.