u/quietfryit

A major study published this year in Nature Medicine combined 11 independent neuroimaging datasets covering DMT, psilocybin, LSD, mescaline, and ayahuasca across 267 participants and over 500 brain-scanning sessions. The clearest shared finding is that all of these compounds increased connectivity between higher-level brain networks (default mode, frontoparietal) and sensory networks (visual, somatomotor). So far, it's one of the most comprehensive picture we have of what psychedelics do to brain circuit function.

The interesting part is that our brain already has the enzymatic machinery to produce DMT on its own. The enzymes INMT and AADC have been identified in human brain tissue, and trace DMT has been detected in cerebrospinal fluid. If exogenous DMT rewires brain connectivity in the dramatic ways the Nature Medicine study documented, what is endogenous DMT doing at lower concentrations?

A research team is trying to figure this out by using simultaneous fMRI and EEG to scan people and look for distinct neural connectivity patterns, called "brain biotypes," that correlate with endogenous DMT activity. The hypothesis is that people with different levels of natural DMT synthesis might have measurably different brain architectures at baseline. So, instead of measuring tissue concentrations (which has produced mixed results across labs), the approach is to look at the functional output. If endogenous DMT matters, it should leave a detectable signature in how the brain organizes its networks.

last week my wife pulled out a couple boxes of coins her dad had purchased at an auction a few years ago. he passed later that year and we're still going through things he left behind. like most everyone else these days- life's getting more expensive. while we were figuring out which bills to pay and what around the house we could sell last weekend, she remembered and retrieved the coin collection. i spent a couple hours using google lens to identify the more interesting looking coins, roughly gauge their demand, and get an idea on what they're being listed for online.

i just went thru this process with 50+ big boxes of trading cards her dad had also purchased at an auction. it made more sense to us to just unload the entire lot and make less $ than if we spent the time and energy on locating and identifying then listing online individual cards or sets of higher value. last month we found a retired local collector who paid us $1000 for the whole lot of 50+ boxes. worked out great- we made some $ and have our spare room closet back and he's got 100,000 cards to spend his retirement going through.

i am entirely unfamiliar with coin collecting and the demand out there for old coins, but did learn that numismatics is a word. we're motivated sellers but of course would like to maximize the amount of $ we could make and am trying to figure out where the balance is before i dive deeper into the process. a friend tells me i'll get hosed selling the lot to a coin shop, but i would very much value that convenience and wouldn't expect that a coin reseller would offer a premium. maybe i'm naïve and assume that a dealer would be honest with an ignorant me on the true value of what's contained in the collection. at the same time, i think it might be worth my time to list and sell some items from the collection individually.

i guess i'm posting this to solicit opinions and thoughts on how best to go about this, if you care to share any.

thanks. hope your day was good.

Keep your kids under control please

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