Lower LDL improves outcomes. Which studies show this?

This may be a question more suited for any medical professionals here, but which study or studies are the primary evidence that lowering LDL leads to improved outcomes for primary prevention? I've read somewhere in the past that this topic used to be controversial, but it doesn't seem to be as controversial anymore.

Or possibly, the controversy was if lowering LDL decreased mortality. Which studies show that lowering LDL decreased 10 year or 30 year mortality?

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u/topologeee — 2 days ago

Noco genius 5 - troubleshoot?

I've had 2 batteries go out in the last year. Completely my fault because I was letting my jeep sit for a month plus. Previously I would have no issue using my noco genius 5 to charge up and maintain the battery. However most recently, I connected it to a battery that had about 5 volts in it. When I came back a few hours later the battery had drained below 2 volts. This happened towards the end of my last battery as well.

Now I'm not sure if that's a battery issue or an issue with the noco genius. I'm not sure how to tell if the noco is working correctly. The most recent battery is only 7 months old and under warranty. The noco genius is about 4 years old. How would I go about troubleshooting the charger? I own a multimeter but have never used it on the charger itself, just the battery.

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u/topologeee — 9 days ago

Nutrition with CKD Stage 3? And other questions

I've posted a few times recently regarding my wife's CKD diagnosis, which is still brand new. At a primary care follow up, I pushed to get a cystatin C which came back pretty consistent with her Scr, which brings her eGFR to 46, 44, or 42, depending on the equation used. I'm unsure if the losartan scr bump actually affects cystatin C as well, so that's been a little confusing.

I'm thinking the kidney damage was most likely caused by the hypertensive crisis that occured 3 months ago, but we do not know the exact cause. It's super unfortunate I couldn't tell the signs until after it had gone on for about a week (headache mostly). My next push will be for imaging to rule out any structural cause.

But in the meanwhile,

Basically I'm here to get an idea of what kind of nutritional changes we should be focusing on. What is the guidance on protein? For dinner I'll usually cook something like chicken breasts, rice or potato, and a veggie. We will do stuff like turkey burgers, bean tacos, homemade fajitas with more veggies than meat, and bean based chili. I've heard so many different takes on the protein thing. What are the recommendations and what does an actual meal look like to you?

Thank you

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u/topologeee — 10 days ago
▲ 2 r/CKD

Statins with CKD

My wife is newly suspected to have CKD (numbers showed consistent with stage 3b, which may change once we get a cystatin C and correct hydration). She's 42 and a BMI of 40.

She also needs to go on a statin. Her LDL came back above 180 despite us eating healthy. For reference, we eat the same things mostly and my LDL is below 100 - so I realize genetics plays a huge role and high cholesterol runs in her family (although cv disease does not).

Considering CKD, which statins have you had luck with? Her family has had horrible luck tolerating statins. Were you on it prior to CKD as well? It was in my head that rosuvastatin would be the best due to its potency and that it may have less myalgia, but I also see that atorvastatin may be marginally safer in CKD. We also probably plan on adding zetia after the initiation of the statin. Thanks

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u/topologeee — 11 days ago

What can you say to someone who is skeptic of statins but needs to take them?

I've been trying to get my spouse, age 42, to start on a statin. Her cholesterol is high (ldl, 180 ish I believe, TGs in 200s) and it's been high for a while now. She has a family history of high cholesterol but very little history of family cv issues. With that, many people in her family have taken statins but discontinue use due to extreme muscle aches, then end up seeking "natural" alternatives or other drugs like ezetimibe. Basically, many people in her immediate family have had bad experiences with statins and share those experiences with her.

What can I say to try to convince her to start? We are seeing primary this week and I'd love to get a prescription for 5 mg rosuvastatin to start. Shes finally considering it since lifestyle changes along barely moved the needle.

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u/topologeee — 13 days ago

Spouse with newly found CKD. Advice?

My spouse may have CKD. I say may, because we are still waiting on the nephrology follow up in a couple of months. We still have a primary follow up this week, and I wanted to see what I should be asking or advocating for in the meantime.

In March she was sent to the ER for hypertensive crisis. ER docs ruled out anything emergent. We still don't know the true cause other than stress and a bad headache that was caused by a cervical spine disc issue. Her BP was peaking over 200 systolic and 110 diastolic in the hospital.

2 weeks prior to the hospital her readings were 120s/70s and was on no medications other than celexa for mental health.

Although labs in the hospital came back within normal limits, her Scr was 1.3, which is high for a female (but apparently still normal for a male, although upper limit). She was placed on Losartan within a week and then had a primary appointment 5-6 weeks later. At her primary appointment her Scr came back 1.56, which is a 20 percent increase from 1.3. Initiating Losartan can absolutely cause this increase. However due to this increase, and this increase alone, the eGFR standard calculation brings her eGFR to 42 which is considered stage 3 CKD.

My issue with this, being a person with a medical background, is that if you use the CrCl equation (which accounts for body mass), the eGFR is like 80. This is due to her BMI being around 40 and the age of 42. She is not diabetic.

We are treating it pretty seriously but feel a little blind. I was considering trying to get them to order a cystatin C to better evaluate but Idk if that's standard. I really hope they would at least re-run a metabolic to make sure it wasn't something temporary from the losartan spike, but I'm not sure if insurance would be okay with that. I know we should still eat healthy but also maybe ease off of stuff like protein shakes. Any advice is appreciated.

In the meanwhile we have been exercising and just focusing on keeping the blood pressure low. Thank you.

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u/topologeee — 15 days ago

Multivitamin or supplement recs?

I have mild mvp with mild symptoms like occasional palpitations. I also have non sustained vtach. I had started taking magnesium orotate based off a study that showed significant quality of life improvement with magnesium and although it could be coincidence, I feel my palpitations have lessened. I also feel sensitive to certain multivitamins and have kind of settled on geritol, perhaps because of the iron content or specific b12 amounts. Centrum for example leaves me feeling jittery.

So now I'm in this rabbit hole. Are there other supplements or specific multivitamins that have helped you? Thank you.

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u/topologeee — 25 days ago