Endurance running and colorectal cancer
In 2025 there was a preliminary study presented at ASCO 2025 and subsequently published in Cancer Epidemiology that reported a relatively high prevalence of colorectal adenomas, including advanced adenomas, among a small cohort of extreme endurance runners. While the study is clearly hypothesis-generating and not sufficient to establish causality, I found the findings extremely intriguing. Funnily enough, I used to compete in road races on a national level for my country and generally thought I had a healthy diet and lifestyle, but ended up with a tuberous adenoma when I did my colonoscopy at 21 as well. There’s no family history of colorectal cancer on my end.
Anecdotally, have you observed a similar pattern among endurance athletes undergoing colorectal cancer screening? What are your thoughts on the proposed mechanisms such as repeated splanchnic hypoperfusion, alterations in the gut microbiome and chronic inflammation?