Just a random thought that i got. We know that lsd ties very neatly into the receptor so i thought what would happen if it got attached permenetly and what benefits that could have.
Im not really into biochemistry and probably know next to nothing appart from high school so please explain it as if i was a 5 year old. Greatly appreciated
I have been trying to get an SPR assay (Biacore t200) to work between a protein ~32 kDa and ATP, but it is going nowhere despite spending so much on chips (I am afraid my PI will just stop me from trying it anymore). I use CM5 amine coupling to immobilize the protein and flow buffer containing various concentrations of ATP through. This image is literally the first time I see one concentration (3.7) that appears to have worked. All the runs have been looking like the other concentrations here, which seem like no binding at all. This kinda gives me some hope, but it has been so depressing trying so many different things that nothing really works. I desperately need this assay to work for my first paper 😞. Any helps/sugegstions are greatly appreciated.
Hey, I'm desesperately trying to draw the bond between a glutamic acid, a valine and another glutamic acid but I'm genuinely struggling.
It's for a tattoo project (it spells "Eve" my niece name).
I tried but I think I got it wrong, can someone help me please ?
Hey guys, if you missed it, Rivian settled $250 million with investors over claims that it failed to disclose the true cost of producing its vehicles. And, I just found out that they’re accepting claims even though the deadline has passed.
Quick recap: In 2022, Rivian was accused of misleading investors about its vehicle pricing and production costs. In short, the company promoted its R1T pickup and R1S SUV as competitively priced electric vehicles, but investors later alleged that Rivian was losing substantial amounts of money on each vehicle sold and failed to clearly disclose how severe the cost gap was. As supply-chain issues and material costs increased, Rivian announced major price hikes that sparked customer backlash and raised concerns about the company’s financial outlook.
Now, the good news is that the company agreed to settle $250 million with them, and even though the deadline has passed recently, they’re accepting late claims.
So, if you invested in $RIVN when all of this happened, you can still check the details and file your claim here.
Anyway, has anyone here invested in $RIVN at that time? How much were your losses, if so?
Hi all, I have a question.
I have been looking into the idea that single celled organisms and individual cells that make up multicellular organisms are themselves sentient. What are your thoughts on this? If so, would this mean they are worthy of our moral obligation?
The one that always got me is uncompetitive. Competitive raising Km and noncompetitive dropping Vmax are easy enough to hold onto, but uncompetitive lowering both felt backwards until I understood why. The inhibitor only binds ES, so removing ES pulls the binding equilibrium forward and the enzyme looks like it grabs substrate more tightly, even though you have capped the ceiling.
I put all four side by side with what happens to Km, what happens to Vmax, and what the Lineweaver-Burk lines actually do, since that is usually the part a question is really testing.
The worked numbers on it use Km 25, Vmax 100 and an inhibitor at twice Ki, so you can see the apparent values rather than just the direction of travel.
Mixed inhibition is the one I am least confident about, since whether Km goes up or down depends on alpha and I have simplified that. If I have oversimplified anything else I would genuinely like to know. Last time I posted here eight people found things and the chart ended up much better for it.
Free and no signup: biochemtools.com/michaelis-menten-vs-lineweaver-burk.html
Vou ter bioquímica nesse semestre da graduação e confesso que estou me CAGANDO de medo dessa matéria, preciso de dicas sinceras do que vocês recomendariam fazer pra ir minimamente bem nela.
I've been experimenting with a prototype molecular visualization workflow that automatically transforms a protein structure into a cinematic walkthrough.
Starting from a PDB structure, the workflow:
Generates a molecular/cartoon representation
*Identifies ligands
*Detects structural features
*Generates labels and annotations
*Creates feature-centered camera shots
*Builds a multi-feature narrative
*Exports a 4K visualization
The goal is to reduce some of the manual work involved in preparing molecular visualizations for presentations, publications, teaching, and scientific communication.
I'm interested in feedback from the chemistry community:
* When presenting molecular structures, what parts of the visualization process are most time-consuming?
* Do you currently create animations for talks or teaching?
* What information would you most like to see highlighted automatically in a molecular walkthrough?
I had dreams of becoming a PA however, a Biochem degree later my GPA is nowhere near what CASPA and any programs in the U.S would accept even after retaking classes (Caspa doesn't replace they average). Med school, PA, CAA, ABSN is all out of the picture. I am trying to figure out what else I can do with this degree. Since my GPA is low I'm not sure if a Masters is an option. I looked up Cardiovascular Perfusionist Certification and I seem to Qualify for a local program so It might be worth applying. Just wanted to know some insight from professionals of this thread. What job do you have that gives you a stable income? Anyone that was in the same situation that can guide me? I'd really appreciate it.
I want to know how this happens. Like, there has to be some bacteria in sakai, japan that uses dihydrogen monoxide reductase or something to eat it. Does anyone here know anything about the subject?
Hey guys! I’m a PhD student, and I originally made this app for myself. I then thought it might be useful for others, so I decided to publish it on the AppStore.
There’s absolutely no commercial motive. The app is completely free, and I just want to help my colleagues.
The biggest problem is: it’s extremely difficult to get the app in front of people. Most communities don’t allow app promotion, and obviously I can’t afford to pay for advertising.
So, I’d really appreciate it if you could share it with other people.
I’m open to all kinds of feedback, positive or negative, so please be honest.
If there’s a feature you’d like to see, let me know. I may be able to add it in the next few days.
Thanks a lot!
The link and more detailed information are on my profile.
Am I crazy or should we not live in a world where acetaldehyde dehydrogenase supplements are widely available. Would this not be effective at moderating liver damage among alcoholics? Is there something that makes the mass production of this enzyme prohibitively expensive? The more I study this subject it feels like liver damage should be a thing of the past.
I am interested in protein design and I am trying to understand one thing: when we design a protein for a specific purpose, what changes in the constraints according to the problem?
For example, I imagine that a therapeutic protein (which must act in the human body) and an industrial enzyme (which degrades a pollutant) do not have the same priorities at all. What becomes critical in each case, and what goes into the background?
If you have concrete examples from your work, I'm interested.
Hey chemistry enthusiasts and puzzle masters - time for a second giveaway!
Core Concept:
Players shoot and merge atoms to create higher elements, trigger chain reactions, discover compounds, and progress through a campaign while building their element collection. It blends satisfying merge gameplay with real periodic table progression. I wanted people to experience the feeling of beeing Mendeleev - discovering all elements in a somewhat unconventional way.
Key Features:
• 100+ campaign levels with unique objectives (adding more in next iteration)
• 6 different themed skins for the board and atom visuals
• Persistent collection system with 118 elements + compound discoveries.
• Daily quests, power-ups, combos ("Atomic Cascade!"), and streak rewards.
• Built with TypeScript/React/TanStack + Capacitor for iOS (since I didn't have a Mac)
• Clean physics-based merging with haptics and juicy feedback.
I focused on making something that I'm fond of (Chemistry), feels good to play in short sessions but has long-term progression and educational charm.
App Store: https://apps.apple.com/us/app/atomic-fusion-rush/id6771701538
How to claim:
Download the app, comment below and I give you the Free Lab Pack
Can you beat the global high-score on the daily challenge?
I am a biochemistry major, and this major forced me to read the lehninger biochemistry book end to end and while doing that I taught my friends, the reviews were awesome and all of them told me that I could make the concepts stick to their heads ? I ain't selling anything here I wanna teach for free and get paid only if people like it
The biochemistry department is at a research-heavy (R1) university in the Northeast.
All the 13 profs who died of cancer also died at 77 or earlier (1 before 50, 1 in his 50s, 3 in their 60s)
Is there any chance the high incidence of cancer (+ leukemia/lymphoma) is significantly caused by their research career?
EDIT: I meant, of the 16 who died (& commemorated) 13 died of cancer, not that the dept had a total of 16 out of which 13 died.
Hi there, not sure if this a typical post for this subreddit, my apologies.
I'm going into the third year of my B.Sc in biochemistry. I do well in my classes, but feel like I simultaneously know nothing. I just started working in a lab on my campus, and I'm going to start volunteering in another come September. I feel like I don't belong. I also worry that I am not smart enough to make it to grad school.
I genuinely feel like I am getting a little burnt out, and I'm just wondering if anyone else here feels similarly at all. I write this while I'm meant to be studying for an exam I have tomorrow, that I am likely going to fail. I'm usually top of my class, but for the last few months, I've been having a hard time. I feel a little lost, and I'm looking for some input.
Thanks :)
