r/MenOnThePen

Interesting.

https://gizmodo.com/an-exercise-pill-just-cleared-its-first-human-test-2000800380

Would you take this?
One of many next-gen obesity treatments currently going through the system.

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About two weeks ago, just before going on holiday, I increased my Mounjaro dose to 4.5 mg.

Since then I’ve been unusually tired, but since coming home last Friday it has become pretty extreme. I feel completely drained, have very little motivation, and my head feels like it’s full of cotton wool. Basically a combination of fatigue and brain fog.

There are a few other factors that could be contributing. I’d just had two busy weeks away, got home on Friday, spent all Saturday organising a big party, saw friends again on Sunday and then went straight back to work this week. The weather here is also very humid, grey and rainy.

What’s strange is that I tend to feel quite a bit better after exercising or going to the sauna. Ibuprofen also seems to reduce the foggy/awful feeling.

I was already more tired than normal during the holiday, although I assumed that was just because we were constantly doing things.

So I’m trying to figure out whether this could be related to the dose increase or whether I’m simply crashing after a very busy couple of weeks.

Did anyone else experience significant fatigue or brain fog after increasing their Mounjaro dose? How long did it take to settle down?

And if you found anything that genuinely helped with the fatigue, I’d love to hear it.

I’ve lost around 20 kg since January and I’m really happy with the progress so far. But I’ve recently noticed these little “flaps” hanging from the underside of my upper arms.

I’m guessing it’s a combination of some remaining fat and loose skin after the weight loss.

Do any of you guys recognize this from your own weight-loss journey?

Did it improve as you lost more weight, or did the loose skin stay? And did building up your triceps/arms make much of a visual difference?

I still want to lose roughly another 10 kg, so I know my body isn’t at its final result yet. I’m mostly curious what other men experienced and what you would do about it: keep losing, focus on muscle afterwards, just give the skin time, or something else?

Would love to hear your experiences!

Pen teardown.

As an engineer I like to know how stuff works, so the pens intrigued me.
So I’ve taken 5 apart to see, and they are quite clever!
What is clear is they cannot and do not ‘count clicks’.

Pic 1 is all the parts. As suspected there is a glass vial inside the main barrel of the pen.

Pics 2 and 3 are like a double slip clutch mechanism and this is how the pen stops turning when the maximum deflection or travel of the plunger is reached.
The 2 black bits are the same, even though the one inside the dose twister looks different in the picture.
They slot together when this mechanism is all together as in pic 6.

If you look at pic 4 you can see the threaded plunger rod and the squared off bit at the end. This same squared off bit is also present at the other end of the rod.
When you turn the dose twister the 2 black slip clutches engage with each other in the white plastic part inside the main body of the pen handle and turn around the plunger rod which is held firm by a locking system in the main body of the pen that I haven’t got to yet. The black half of the clutch part in the twister turns as you twist

When you the press the purple nob as you inject, the top part of the clutch locks so it doesn’t turn, this then locks the lower part which presses the rod down into the pen.

In pic 4 you can see the threaded plunger rod with the squared off ends. As you use the pen, once you twist it up to the squared bit it can’t move any further unless forced.
This is what locks the pen.

You can see in pic 5 what happens when you force it past the lock. A bit breaks off.
This means we were able to advance the twister further up the rod and get the extra travel on the plunger required to get the extra dose. But this was in no way measured or accurate. Just that the difference wasn’t really an issue.

The new pens are exactly the same with the simple addition of the spacer as seen in pic 7. You can just see that this spacer is 1 dose in size, thereby extending the effective travel of the plunger and eliminating the extra dose.

And that’s it. Very simple yet clever and accurate. Got hold of a Lilly insulin pen and took that apart as well and they are the same with the only difference being the plunger rod is black and longer so it goes all the way to the end of the vial.

:-)

Hi everyone,

Since January, I’ve lost 20 kg (44 lbs) and I’m really happy with the progress so far. I’d like to lose at least another 10 kg (22 lbs), but my longer-term goal isn’t just to be lighter — I’d love to build more of a rugby-player physique: solid, strong and muscular rather than super lean.

A bit of context:

- I’m using Mounjaro, currently 4.5 mg

- My testosterone has gone from 12 nmol/L in January to 25.5 nmol/L now, completely naturally

- I train 3x a week using eGym strength machines

- I average around 12,000 steps a day

- I eat roughly 2,000 kcal a day

- I make a conscious effort to keep my protein intake high

The fat loss is going really well, but I feel like my muscle growth is lagging behind. Obviously, I know that being in a calorie deficit isn’t the ideal environment for building a lot of muscle, so some of that is completely expected.

Still, I’d really like to maximise muscle retention and, if possible, build some additional muscle while I continue losing the final 10 kg.

So my question is: what would be your best “body hack” for my situation?

Would you change the training volume, switch away from eGym to more free weights, increase calories slightly, change protein intake, add creatine, or simply accept that serious muscle growth needs to wait until I’m closer to my goal weight?

Interested to hear what has actually worked for people who have successfully combined major weight loss with building a stronger, more muscular physique.