r/MuscleTwitch

I’m looking for honest opinions because I’m still struggling with the fear of ALS, even though every neurologist I’ve seen has reassured me.

My symptoms started around September 2025 with widespread muscle twitching and muscle tightness. The twitching has actually improved a lot over time and isn’t really my concern anymore.

What worries me now is my right calf. Around January 2026 I noticed it looked smaller than my left. It feels softer and different to me, and it gets tired or burns more quickly during calf raises. I don’t know if it’s true weakness or if I’m hyperfocused on it.

Here’s everything I’ve had done:
4 EMGs/NCS over several months (including testing of both legs, all four limbs, and multiple muscles in my right calf) — all completely normal. By two different neurologists.
Brain MRI — normal.
Cervical spine MRI — normal.
Lumbar spine MRI — only a mild L5-S1 disc bulge, nothing significant.
Multiple neurological examinations with normal strength and normal reflexes.
Also my twitching has pretty much stopped.

CK: 56 (normal).
Neurofilament light chain (NfL): normal.

ANA: negative.
Other blood work has been unrevealing.
I’ve seen multiple neurologists, and every one of them has told me they do not think I have ALS. One neurologist even felt another EMG wasn’t necessary because my previous studies were normal.

Despite all of that, I can’t stop worrying because my right calf still feels different and looks smaller to me.
Also my leg is in pain it feels so different and weird.

If you were in my situation—with these symptoms, this amount of testing, and multiple neurologists saying it isn’t ALS—would you still be worried about ALS? Has anyone else had one calf seem smaller or feel different but end up with a non-ALS explanation?

I’m looking for honest experiences and thoughts, not just reassurance.

Has anyone else with long-term fasciculations experienced a sudden calf cramp like this? Is this something that can happen with benign fasciculation syndrome (BFS), or should I be more concerned?

Has anyone gotten an NFL test? I just got my results and I’m almost on the red so I’m freaking out. But it does say normal. Any opinions or thoughts would be greatly appreciated.

https://www.reddit.com/r/ALSorNOT/s/qIMkdBATgm
I have had 4 normal emgs, normal NFL and pass all clinical exams. Coming up on month 10. Twitching has gotten much less. Just concerned about my right leg feeling weird and smaller. Thank you for any help.

Been dealing with this for 15 years. Remember the early days of Googling symptoms at 2am convincing myself it was ALS — not fun.

Learned a lot along the way about triggers, management, getting out of the anxiety loop. Put together some resources recently if anyone's interested, but mostly just happy to chat if you're struggling.

DM me or drop a comment.

Is this normal?

So I’ve been having twitches literally everywhere for about 10 months as a 22 year old man but today my right forearm has absolutely exploded with twitches. Like to the point I’m not getting more than 20 seconds without a bundle of short fast twitches.

I can’t remember really getting many twitches there before today which is why I’m so puzzled as to why that has exploded just today