r/Virology

We have published a preprint titled “Evolutionary shifts in spike glycan-binding specificity suggest a possible association with host adaptation during SARS-CoV-2 Omicron evolution” .

Science has a history of favoring specific groups of people. In 1977, Dr. Louise Chow's EM studies were instrumental in the discovery of RNA splicing. Yet in 1993, she was excluded from the Nobel Prize for the discovery. Despite this, she continued to change science. Her work with HPV unlocked mysterious of the cancer causing virus and helped influence vaccine and treatments.

While the Nobel committee may have overlooked her, the Titans of Virology and Vaccinology Podcast was lucky enough to get to hear her story. Like many great women in science, it is time for her moment.

If HIV concentration in lymph fluid is 1000x more concentrated in lymph fluid than in blood, why isn’t it listed as an OPIM for HIV transmission?

Its been shown that nearly 11% of people living in the Peruvian jungle have antibodies towards rabies, indicating that their bodies cleared a peripheral infection before it got to the brain. However, medical research often tells us that without PEP, we will most certainly succumb to it. How can both of these studies co exist?

My only guess is that perhaps the people in Peru are being subjected to a weaker strain, but i am by no means an expert.

Hi I have a cell line infected with flu tagged to GFP for growth kinetics (24/48/72 hpi). Supernatant is harvested for quantification, and I want to harvest the cells for flow (GFP+) for the 3 timepoints. I have a vehicle (veh, negative) control in parallel.

Just wondering, when gating GFP+ cells at for each timepoint, should I gate it with the veh control of that particular timepoint? i.e. 24 h veh for 24 hpi; 48 h veh for 48 hpi; 72 h veh for 72 hpi. Or simply a random veh control suffices for all timepoints of my flu-GFP.

so this evening, i was at work (which should be noted is in an urban neighbourhood area) and i was throwing out the garbage. i noticed two garbage bins were open, so i decided to throw the bags into those bins. as i'm throwing one of two bags into the bins, i start hearing this growling noise. it takes me a few seconds to realise it's probably a raccoon that had gotten into the bin. once i realised what it was, i ran as quickly as i could back to the door of my workplace. obviously i know i likely would have felt it scratch or bite me, but i have severe hypochondria and now i can't help but think that maybe i missed something. i also do have a blister scab that's dry and healed, but it's still a wound, so if saliva had gotten onto it somehow, or maybe i missed a small scratch mark, could i be at risk for rabies? again, i know i didn't even see the raccoon or feel it, and it did stop growling after i had ran away and i didn't see or hear it at all after this encounter, but do you think i should get rabies vaccines?

The body will run a fever fighting off viruses, etc. so is there anything that would cause a drop in temperature other than hypothermia?