u/Constant_Region_9999

Hi everyone,

I’m currently in the middle of a diagnostic workup with my specialists (gastroenterologist, allergist/immunologist, and psychiatrist) to figure out what’s going on with my body. I wanted to reach out to hear about your personal journeys if you’ve experienced a similar overlap.

Here is a summary of what I’m dealing with:

Extreme Neuro, Supplement & Medication Sensitivity:
I’ve been prescribed over 6 different psychiatric medications for F-diagnoses (mood/anxiety/functional issues), and I suffered extreme adverse reactions to every single one without any positive effect. My psychiatrist has now stopped all psychiatric meds, concluding that my nervous system is hyper-reactive and that I likely have an underlying genetic polymorphism affecting drug metabolism. We are now exploring alternative support (psychobiotics, methylene blue, etc.).

Even simple supplements trigger severe reactions—for example, taking magnesium bisglycinate caused extreme, painful calf cramps and intense muscle/eyelid twitching.

Interestingly, the only medications I tolerate well are GABA-agonists (like alprazolam and clonazepam) and Ketoprofen (NSAID).

GI & Allergic/Histamine Picture: Severe gut hypersensitivity, sudden reactions to foods and drinks (flushing, bowel urgency, severe spasms), and confirmed IgE sensitivities to specific food proteins (milk protein, wheat, legumes).

Skin/Systemic Symptoms: Unexplained itching around joints and eyes without a visible rash, and a past acute reaction (hives) to an energy drink.

My medical team is looking into the connection between gut lining inflammation, mast cell activation/histamine issues, genetic drug metabolism, and autonomic nervous system dysregulation.
For those of you who have a diagnosed overlap between dysautonomia/POTS, Mast Cell Activation (MCAS), or severe medication/supplement sensitivity:
Has anyone else experienced extreme paradoxical reactions to basic supplements (like magnesium) or psychiatric medications due to nervous system or mast cell reactivity?

Did genetic testing (like pharmacogenomics, MTHFR, or methylation panels) or exploring alternative gut-brain therapies help guide your treatment?

What specific questions or tests were most helpful to discuss with your autonomic or allergy specialists during your initial visits?

Note: I am NOT asking for a diagnosis, medical advice, or interpretation of results. I am working closely with my doctors and preparing for upcoming specialist visits. I’d just love to hear your personal experiences and what helped you navigate a hyper-sensitive system!

Hi everyone,

I’m a 24-year-old female (5'5" / 166 cm, 119 lbs / 54 kg) looking for clinical perspectives or guidance on what diagnostic steps to take next for a long-standing, highly complex health situation.

I am a cigarette smoker, and my only current medication is Clonazepam (Rivotril) at 0.5 mg (a quarter of a 2mg tablet) taken at night.

Context on Medical History & Dismissal:

Ten years ago, when these GI symptoms first started, local physicians couldn't find a cause and simply slapped me with an IBS diagnosis, sending me to psychiatry where they claimed I had depression despite me being completely mentally healthy at that time. They didn't even prescribe any medication then. Because my physical issues went unaddressed for a decade, the chronic suffering eventually led to genuine, more severe psychological distress in recent times.

Currently, I have formal codes for recurrent depressive disorder, severe episode (F33.2), and emotionally unstable personality disorder - borderline type (F60.3) in my record. Unfortunately, because these codes exist, doctors continuously dismiss my physical symptoms as "purely psychosomatic."

To make matters worse, I have a family history of Gilbert's Syndrome. When I brought this up to a hepatologist, he dismissed me out of hand, asking only "Do you turn yellow when you don't eat?" and when I said no, he claimed "Only men get Gilbert's anyway," completely brushing off my concerns.

Gastrointestinal Symptoms & Severe Maldigestion (10+ Years):

Diarrhea & Gas: Chronic diarrhea ~80% of time. I suffer from extreme, severe intestinal gas and bloating - literally feels like constant explosions and intense rumbling/twisting in my intestines triggered by almost any food.

Maldigestion: A stool microscopy (coprogram) explicitly confirmed the presence of undigested fats, muscle fibers, and starches.

Appetite: Over the last 5 to 6 years, my appetite has dropped to almost zero. I eat very little, yet the diarrhea, severe gas, and maldigestion persist unchanged.

Upper GI: A gastroscopy confirmed a hiatal hernia, and I frequently feel a sharp, pinching or tugging sensation in my upper stomach area.

Severe & Paradoxical Drug/Supplement Sensitivity: What makes my case particularly difficult is an extreme sensitivity to roughly 90% of oral medications and supplements:
Standard GI medications like PPIs (pantoprazole, esomeprazole), antispasmodics (mebeverine), digestive probiotics, and simethicone don't help at all. Instead, they induce severe nausea, intense headaches, or exacerbate GI distress.

Trials of various psychotropic drugs led to severe paradoxical reactions - so much so that my treating psychiatrist advised stopping all psychotropic trials altogether until the underlying physical and metabolic causes are investigated.

Even basic over-the-counter supplements like Magnesium Bisglycinate cause paradoxical agitation and distress, including really painfull leg cramping.

Interestingly, the only medications I tolerate without adverse side effects are certain benzodiazepines (clonazepam, alprazolam) and a specific NSAID combination (ketoprofen).

Current Diagnostic Workup:

My standard blood panels (CBC, liver enzymes, pancreatic enzymes, and total bilirubin) are all completely normal. I recently had a duodenal biopsy during my gastroscopy and am currently awaiting the histopathology results to evaluate mucosal integrity and mast cell involvement. Moving forward, I am planning to test for Fecal Pancreatic Elastase-1, Zonulin, Secretory IgA (sIgA), and potentially get a SIBO breath test.

Questions:

Could an impaired intestinal barrier (Leaky Gut) or GI mucosal Mast Cell Activation (MCAS / mastocytic enteritis) explain such immediate paradoxical reactions to simple oral compounds and supplements?

Given normal routine bloodwork alongside severe maldigestion, extreme gas, and drug hyper-reactivity, what specific metabolic, neuro-gastroenterological, or immunological conditions should be ruled out?

What sub-specialist or specialized diagnostic panel would be most appropriate to consult for this picture?

Thank you so much for your time and insights.

Hi everyone,

I’m a 24-year-old female (5'5" / 166 cm, 119 lbs / 54 kg) looking for clinical perspectives or guidance on what diagnostic steps to take next for a long-standing, highly complex health situation.

I am a cigarette smoker, and my only current medication is Clonazepam (Rivotril) at 0.5 mg (a quarter of a 2mg tablet) taken at night.

Context on Medical History & Dismissal:

Ten years ago, when these GI symptoms first started, local physicians couldn't find a cause and simply slapped me with an IBS diagnosis, sending me to psychiatry where they claimed I had depression despite me being completely mentally healthy at that time. They didn't even prescribe any medication then. Because my physical issues went unaddressed for a decade, the chronic suffering eventually led to genuine, more severe psychological distress in recent times.

Currently, I have formal codes for recurrent depressive disorder, severe episode (F33.2), and emotionally unstable personality disorder - borderline type (F60.3) in my record. Unfortunately, because these codes exist, doctors continuously dismiss my physical symptoms as "purely psychosomatic."

To make matters worse, I have a family history of Gilbert's Syndrome. When I brought this up to a hepatologist, he dismissed me out of hand, asking only "Do you turn yellow when you don't eat?" and when I said no, he claimed "Only men get Gilbert's anyway," completely brushing off my concerns.

Gastrointestinal Symptoms & Severe Maldigestion (10+ Years):

Diarrhea & Gas: Chronic diarrhea ~80% of time. I suffer from extreme, severe intestinal gas and bloating - literally feels like constant explosions and intense rumbling/twisting in my intestines triggered by almost any food.

Maldigestion: A stool microscopy (coprogram) explicitly confirmed the presence of undigested fats, muscle fibers, and starches.

Appetite: Over the last 5 to 6 years, my appetite has dropped to almost zero. I eat very little, yet the diarrhea, severe gas, and maldigestion persist unchanged.

Upper GI: A gastroscopy confirmed a hiatal hernia, and I frequently feel a sharp, pinching or tugging sensation in my upper stomach area.

Severe & Paradoxical Drug/Supplement Sensitivity: What makes my case particularly difficult is an extreme sensitivity to roughly 90% of oral medications and supplements:
Standard GI medications like PPIs (pantoprazole, esomeprazole), antispasmodics (mebeverine), digestive probiotics, and simethicone don't help at all. Instead, they induce severe nausea, intense headaches, or exacerbate GI distress.

Trials of various psychotropic drugs led to severe paradoxical reactions - so much so that my treating psychiatrist advised stopping all psychotropic trials altogether until the underlying physical and metabolic causes are investigated.

Even basic over-the-counter supplements like Magnesium Bisglycinate cause paradoxical agitation and distress, including really painfull leg cramping.

Interestingly, the only medications I tolerate without adverse side effects are certain benzodiazepines (clonazepam, alprazolam) and a specific NSAID combination (ketoprofen).

Current Diagnostic Workup:

My standard blood panels (CBC, liver enzymes, pancreatic enzymes, and total bilirubin) are all completely normal. I recently had a duodenal biopsy during my gastroscopy and am currently awaiting the histopathology results to evaluate mucosal integrity and mast cell involvement. Moving forward, I am planning to test for Fecal Pancreatic Elastase-1, Zonulin, Secretory IgA (sIgA), and potentially get a SIBO breath test.

Questions:

Could an impaired intestinal barrier (Leaky Gut) or GI mucosal Mast Cell Activation (MCAS / mastocytic enteritis) explain such immediate paradoxical reactions to simple oral compounds and supplements?

Given normal routine bloodwork alongside severe maldigestion, extreme gas, and drug hyper-reactivity, what specific metabolic, neuro-gastroenterological, or immunological conditions should be ruled out?

What sub-specialist or specialized diagnostic panel would be most appropriate to consult for this picture?

Thank you so much for your time and insights.

Hi everyone,

I’m a 24-year-old female (5'5" / 166 cm, 119 lbs / 54 kg) looking for clinical perspectives or guidance on what diagnostic steps to take next for a long-standing, highly complex health situation.

I am a cigarette smoker, and my only current medication is Clonazepam (Rivotril) at 0.5 mg (a quarter of a 2mg tablet) taken at night.

Context on Medical History & Dismissal:

Ten years ago, when these GI symptoms first started, local physicians couldn't find a cause and simply slapped me with an IBS diagnosis, sending me to psychiatry where they claimed I had depression despite me being completely mentally healthy at that time. They didn't even prescribe any medication then. Because my physical issues went unaddressed for a decade, the chronic suffering eventually led to genuine, more severe psychological distress in recent times.

Currently, I have formal codes for recurrent depressive disorder, severe episode (F33.2), and emotionally unstable personality disorder - borderline type (F60.3) in my record. Unfortunately, because these codes exist, doctors continuously dismiss my physical symptoms as "purely psychosomatic."

To make matters worse, I have a family history of Gilbert's Syndrome. When I brought this up to a hepatologist, he dismissed me out of hand, asking only "Do you turn yellow when you don't eat?" and when I said no, he claimed "Only men get Gilbert's anyway," completely brushing off my concerns.

Gastrointestinal Symptoms & Severe Maldigestion (10+ Years):

Diarrhea & Gas: Chronic diarrhea ~80% of time. I suffer from extreme, severe intestinal gas and bloating - literally feels like constant explosions and intense rumbling/twisting in my intestines triggered by almost any food.

Maldigestion: A stool microscopy (coprogram) explicitly confirmed the presence of undigested fats, muscle fibers, and starches.

Appetite: Over the last 5 to 6 years, my appetite has dropped to almost zero. I eat very little, yet the diarrhea, severe gas, and maldigestion persist unchanged.

Upper GI: A gastroscopy confirmed a hiatal hernia, and I frequently feel a sharp, pinching or tugging sensation in my upper stomach area.

Severe & Paradoxical Drug/Supplement Sensitivity: What makes my case particularly difficult is an extreme sensitivity to roughly 90% of oral medications and supplements:
Standard GI medications like PPIs (pantoprazole, esomeprazole), antispasmodics (mebeverine), digestive probiotics, and simethicone don't help at all. Instead, they induce severe nausea, intense headaches, or exacerbate GI distress.

Trials of various psychotropic drugs led to severe paradoxical reactions - so much so that my treating psychiatrist advised stopping all psychotropic trials altogether until the underlying physical and metabolic causes are investigated.

Even basic over-the-counter supplements like Magnesium Bisglycinate cause paradoxical agitation and distress, including really painfull leg cramping.

Interestingly, the only medications I tolerate without adverse side effects are certain benzodiazepines (clonazepam, alprazolam) and a specific NSAID combination (ketoprofen).

Current Diagnostic Workup:

My standard blood panels (CBC, liver enzymes, pancreatic enzymes, and total bilirubin) are all completely normal. I recently had a duodenal biopsy during my gastroscopy and am currently awaiting the histopathology results to evaluate mucosal integrity and mast cell involvement. Moving forward, I am planning to test for Fecal Pancreatic Elastase-1, Zonulin, Secretory IgA (sIgA), and potentially get a SIBO breath test.

Questions:

Could an impaired intestinal barrier (Leaky Gut) or GI mucosal Mast Cell Activation (MCAS / mastocytic enteritis) explain such immediate paradoxical reactions to simple oral compounds and supplements?

Given normal routine bloodwork alongside severe maldigestion, extreme gas, and drug hyper-reactivity, what specific metabolic, neuro-gastroenterological, or immunological conditions should be ruled out?

What sub-specialist or specialized diagnostic panel would be most appropriate to consult for this picture?

Thank you so much for your time and insights.

Hi everyone,

I’m a 24-year-old female (5'5" / 166 cm, 119 lbs / 54 kg) looking for clinical perspectives or guidance on what diagnostic steps to take next for a long-standing, highly complex health situation.

I am a cigarette smoker, and my only current medication is Clonazepam (Rivotril) at 0.5 mg (a quarter of a 2mg tablet) taken at night.

Context on Medical History & Dismissal:

Ten years ago, when these GI symptoms first started, local physicians couldn't find a cause and simply slapped me with an IBS diagnosis, sending me to psychiatry where they claimed I had depression despite me being completely mentally healthy at that time. They didn't even prescribe any medication then. Because my physical issues went unaddressed for a decade, the chronic suffering eventually led to genuine, more severe psychological distress in recent times.

Currently, I have formal codes for recurrent depressive disorder, severe episode (F33.2), and emotionally unstable personality disorder - borderline type (F60.3) in my record. Unfortunately, because these codes exist, doctors continuously dismiss my physical symptoms as "purely psychosomatic."

To make matters worse, I have a family history of Gilbert's Syndrome. When I brought this up to a hepatologist, he dismissed me out of hand, asking only "Do you turn yellow when you don't eat?" and when I said no, he claimed "Only men get Gilbert's anyway," completely brushing off my concerns.

Gastrointestinal Symptoms & Severe Maldigestion (10+ Years):

Diarrhea & Gas: Chronic diarrhea ~80% of time. I suffer from extreme, severe intestinal gas and bloating - literally feels like constant explosions and intense rumbling/twisting in my intestines triggered by almost any food.

Maldigestion: A stool microscopy (coprogram) explicitly confirmed the presence of undigested fats, muscle fibers, and starches.

Appetite: Over the last 5 to 6 years, my appetite has dropped to almost zero. I eat very little, yet the diarrhea, severe gas, and maldigestion persist unchanged.

Upper GI: A gastroscopy confirmed a hiatal hernia, and I frequently feel a sharp, pinching or tugging sensation in my upper stomach area.

Severe & Paradoxical Drug/Supplement Sensitivity: What makes my case particularly difficult is an extreme sensitivity to roughly 90% of oral medications and supplements:
Standard GI medications like PPIs (pantoprazole, esomeprazole), antispasmodics (mebeverine), digestive probiotics, and simethicone don't help at all. Instead, they induce severe nausea, intense headaches, or exacerbate GI distress.

Trials of various psychotropic drugs led to severe paradoxical reactions - so much so that my treating psychiatrist advised stopping all psychotropic trials altogether until the underlying physical and metabolic causes are investigated.

Even basic over-the-counter supplements like Magnesium Bisglycinate cause paradoxical agitation and distress, including really painfull leg cramping.

Interestingly, the only medications I tolerate without adverse side effects are certain benzodiazepines (clonazepam, alprazolam) and a specific NSAID combination (ketoprofen).

Current Diagnostic Workup:

My standard blood panels (CBC, liver enzymes, pancreatic enzymes, and total bilirubin) are all completely normal. I recently had a duodenal biopsy during my gastroscopy and am currently awaiting the histopathology results to evaluate mucosal integrity and mast cell involvement. Moving forward, I am planning to test for Fecal Pancreatic Elastase-1, Zonulin, Secretory IgA (sIgA), and potentially get a SIBO breath test.

Questions:

Could an impaired intestinal barrier (Leaky Gut) or GI mucosal Mast Cell Activation (MCAS / mastocytic enteritis) explain such immediate paradoxical reactions to simple oral compounds and supplements?

Given normal routine bloodwork alongside severe maldigestion, extreme gas, and drug hyper-reactivity, what specific metabolic, neuro-gastroenterological, or immunological conditions should be ruled out?

What sub-specialist or specialized diagnostic panel would be most appropriate to consult for this picture?

Thank you so much for your time and insights.

Pozz ljudi, molim vas da podelite svoja iskustva sa ovom ordinacijom, tacnije sa lekarom dr Petrom Vojvodicem.
U fazi sam trazenja adekvatnog lekara za svoje stanje i dosao sam do njega, ali nisam uspeo da nadjem neka iskustva sa njim, pa bi mi mnogo znacilo da podelite svoja. Moze i u pp

Hvala puno

Zdravi ljudi, treba mi pomoć.

Već petnaestak dana pijem terapiju Seroxat 20mg i Bipodis 2x5mg, ali poslednjih nekoliko dana imam nepodnošljivu potrebu za kretanjem, a u isto vreme stravičan umor. Takođe mi se tresu glava i ruke.

Lečim se kod privatnog psihijatra, čiji broj nemam. Da li mogu da pozovem neku dežurnu psihijatrijsku ustanovu za savet? Da li znate koja je to i koji je broj? Ništa ne mogu da nađem na netu