Reference to Mikey's drug abuse in the show
At the beginning of one of the Latin American shows, Mikey goes against the rules by taking multiple pills instead of just one. Both the Clerk and Sylvia freak out when this happens. But when it happens again, only the Clerk freaks out over it, while Sylvia just sighs and rolls her eyes. Then, Mikey rebels even more by taking another pill Frank hid in his jacket.
It's interesting that there would clearly be references to what was the darkest time in Mikey's life--which included landing him in the hospital, even.