
Could excessive silica exposure kill Homelander?
It just seems to stand to reason that his lungs probably aren't much more capable than those of a normal person of expelling fine silica dust and too much of that would probably still give him silicosis. And as far as we know, he still needs his lungs to absorb oxygen for him to survive.
For that matter, most other highly durable supes in The Boys or Gen V probably have the same weakness. I'm not even sure why DC's Superman wouldn't have the same weakness (at least the Gunn incarnation). But Kimiko is likely an exception since her lungs could just be removed one at a time and they would grow back.
Assuming it's what Clara would have wanted, of course.