Vitamin A not being metabolized? What can block metabolic pathways of vitamin A?

Doctors have been no help. I know I need to see a hepatologist, but it is not so easy for me to get out and about these days.

"Attempted" TL;DR; version:
Suspect high vitamin A is preventing breakdown of beta carotene, causing carotenemia.
High vitamin A induces CYP3A4 to breakdown excess.
Consume very little preformed vitamin A so seems it's metabolic pathways are blocked.
Started meds in 2022 and 2023 that inducers of 3A4.
Simvastatin stopped working, LDL cholesterol doubled. Switched to statin with no P450 issues.
LDL transports vit. A, more transport, more vitamin A correlation. LDL cholesterol and Vit A both still over 100.
Double statin, meds start to work better, won't let me reduce it. Ran out of extra, months hoping meds start working better.
4 meds primarily metabolized by 3A4 currently that don't work well when induced too much.
3A4 has been an issue here and there but got things working. Incident in November screwed that all up and 3A4 seems over sensitive to change in 3A4 activity, not just levels. Inhibitors cause rebound over compensation and in general meds have not been up to par since October.
Ran out of 1 drug, less competition, more share of 3A4 activity for others, they work even less. Body takes too damn long to adjust.
Odd thing, years of yellow/orange skin tone. off adderall for a few months, starts going away. Back on, came back.

So, any guesses as to what is going on?
LDL, Vit A, Notes
124, 83. Statin not working due to CYP3A4 too high.
160, N/D, asked to switch statins, underdosed.
144, 112, statin increase, not as much as I wanted, ignored request and reasons.
Doubled statin dose with extra on hand to rule in/out LDL correlation with Vit, A levels. Damn, it helped. Loser Vit A. Lower 3A4 induction, meds start to work better. Ran out of extra. Screwed for months still.
122, 107, Can't get to dock, doubling what I do have, ran out of one med that shared 3A4 activity making other 3 work even less.

Questions:

--Looks like retinoids profile and CYP26 family of enzymes tests is something only in research?
--Assume hepatologist will test for CYP3A4 activity?
--Is high vitamin A with low consumption one of those things not well understood?
--Any way to boost vitamin A metabolic pathways? So my body can better manage 3A4 activity without Vitamin A causing induction?
--What am I missing, in simple terms? Way too much complexity with the underlying physiology and biochemistry. Time to ask for insights.

Theory, guess, whatever you want to call it, expanded ie more clutter but details might be relevant if bored enough:
--Elevated Vit. A preventing breakdown of beta-carotene. Causing mild carotenemia since ballpark 2017 that just looked like a slight tan on head and neck that wouldn't go away.
--Vitamin A not properly metabolizing, currently in the potentially toxic zone over 100 (last test 107 down from 114).
--Don't take vitamin A or beta-carotene supplements. Except what is in my multivitamin. Which as of 2/2026 does not have preformed vitamin A, just beta-carotene. Crap diet of processed foods offers very little Vitamin A, far less than half TUL daily. When NIH and other sources say you need thousands of mcg vitamin A supplementation over months to get potentially toxic levels over 100 (depending on source, above 80 to 100)
--Inducing CYP3A4 is bodies way to attenuate high levels of vitamin A. Which decreases effect of 4 meds primarily metabolized by 3A4.
--Carotenemia got worse after starting potent inducer of 3A4 in 2022. And worse again in 2023 when increased dose.
--Started second potent 3A4 inducer med 2023, Simvastatin metabolized by 3A4 stopped working. LDL doubled.
--Read there is a relation between increased LDL and increased Vitamin A. Correlation is LDL is one of Vitamin A's transports and more transport results in more serum Vitamin A levels.
--Vitamin A seems like it went up/down with LDL cholesterol, but only have 3 Vitamin A tests.
--Incident in 11/2025 caused a lot of stuff to get out of whack, ER meds and a couple new supplements mess with 3A4, which pissed off vitamin A and now it seems like change is enough of a trigger, not necessarily actual 3A4 activity. Anything that suppresses 3A4 results in rebound higher activity that takes a while to chill out. Still trying just to get back to my pre-incident 11/2025 level of dysfunction.
--Doubling cholesterol meds (pravastatin 80 mg) should decrease LDL and if correlation with Vitamin A is a real factor, Vit. A should go down too, and stop inducing CYP3A4 activity as much. Which actually worked. Then tapering to 60 mg caused steady decline of 4 meds effects for a week. Tried 80 again, after 3 days started to improve. Ran out of extra. Stuck at 40 and sucked for months on end.
--Mystery WTF in 5/2026 made things weird. Skipping details. Everything got worse. in bed 30 hours, then got some very minimal avolition relief and started chipping away at infinitely long TODO list. executive function up (ish), avolition down, wakefulness down....WTF? Plus some other weird stuff.
--Ran out of 1 of 4 of the 3A4 substrate meds, and less competition seems to mean more 3A4 for other meds. Boooooo!!. 3 remaining less effective. Slowly body getting better balance and slowly improving, which may just be a fluke and time will tell. No idea what will happen when finally get 4th med again. As competition for 3A4 may cause vit. A to induce activity and overshoot again.

More odd stuff.
--On Adderall since 2007. On addy brake, carotenemia started to go away. Back on addy, comes back to previous level. Maybe amphetamines over time can have some indirect effect on CYP26 family or other Vitamin A metabolizing pathway? Before you yell at me for the assumption...Don't shoot the messenger. Take adderall, turn yellow/orange for years. Stop Adderall a few months, starts to go away. Start Adderall again, comes back.
Already destroyed my life with cognitive and endocrine side effects. At and below prescribed dose. There's a reason drug companies limited research to 6 weeks max. ....

--Odd stuff number 2. Not even sure when carotenemia actually started as it snuck up on me. Along with looking like a very slight tan the first few years, hairs that used to stick up from my chest in front of my neck disappeared, I think at the same time. Fall 2021 see rash of "white macules" on chest "lacy pattern" on top like 1.5 feet of body when mild red flushing happens, and hair fell out on ankles and outer facing calves. Antifungal and antibiotic creams just irritate skin. Long story short, spring 2022, Cutaneous T-Cell Lymphoma (CTCL), mycosis fungoides, likely FMF variant. Blood cancer that presents in the lymphatic system in the skin. Detected much earlier than the average person. Well, vitamin A and various retinol metabolites regulate skin and T-cell function. Seems like I'm not breaking down Vitamin A into those things. Coincidence?
One of the most common treatments is retinol or some vitamin A metabolite cream. Which I have never used. Which wouldn't be an option even if I wanted it.

Timeline of sucks to be me
2017/18 maybe earlier, started to see slight tan of head and neck that didn't go away despite not getting any sun. Mild carotenemia, later figured out.
09/2021 LDL 70
07/2022 Started titrating first potent 3A4 inducer med. Started increasing Adderall that it was also interfering with. Carotenemia would also start increasing. And go to hands and soles of feet. And a little over knees where skin condition thickened skin a bit. yellow/orange color.
09/2022 LDL 64
01/2023 Upped dose of 3A4 inducer.
03/2023 LDL 81
07/2023 LDL 82
10/2023 Started second potent 3A4 inducer med.
10/2023 to 03/2024 off 1st inducer med. Then back to low dose.
01/2024 to 03/2024 Off Adderall, then intermittent till sometime in the fall. When totally off did see only significant downward trend for carotenemia. Can only think Adderall is some roundabout way inhibits with CYP26 family or something along those lines? Back on addy, carotenemia went back to where it was.
03/2024 LDL 108
08/2024 LDL 124, Vit. A 83.5 ug/d (asked for vit A and beta carotene but only got vit A added)
11/2024 LDL 129
07/2025 LDL 160 Asked doc to switch to pravastatin due to 3A4 issue affecting simvastatin. Underdosed me.
11/2025 Drama, meds balance thrown out of whack as well as 3A4. ER docs give me meds that mess with 3A4. Afterward, anything that may reduce 3A4 results in higher activity rebound instead. And 4 meds working less. And lots of ups and downs trying to regain partial functionality again (cognitive issues with meds).
12/2025 LDL 144, Vit A 114
--Doc ups pravastatin to 40. Tell him theory about LDL and Vit A. levels and ask to go higher on pravastatin then maintenance dose when things are back under control. And can rule in or out wild theory as I am desperate to get meds working at regular dysfunctional levels. Lazy %#$@, dumb excuse and just stays with 40.
--Quest Diagnostics Blood test recommended 40 to 80 pravastatin, and all sources say you don't treat LDL like a long term gradual decrease. You get it down.
--So, had extra 20mg, took 80mg, all four 3A4 metabolized meds improved, tapered to 60mg. Steady decrease in function for a week. Tried 80 again and after a few days meds get better again. Even if wild theory is wrong, increasing LDL meds worked. Ran out of extra, stuck on 40mg. Struggle the next few months to normalize. Some gains but not back to my normal level of dysfunction.
--First potent inducer is once a week. Take it, meds work less. 3 days later improves gradually till next dose. Did get less sensitive to fluctuation. Other potent inducer, had to go to max dose prescribed trying desperately to get stuff done.
02/2026 Changed multivitamin to all beta-carotene, no preformed A. Carotenemia goes up slightly, then decreases a little below previous level and stays there.
05/2026 Something happened, low probability but might be drama from 11/2024 getting to me again. Totally screws up little gains I had. But, very weird, get some elusive executive function and reduction of avolition. But a lot of wakefulness lost. Did see a turn around 2 or 3 weeks later after spending 30 hours in bed. But, still sucks to be me. Started to feel like not getting enough oxygen, like always in a stuffy room no matter what. Increased respiration rate and heat rate.
06/2026 LDL 123, Vit A. 107 Got 3 month fill of pravastatin. Doc needs to see in person before more meds, can't from out of state. Doubling up to 80 prav while looking into options. Do seem to be improving but need time to be sure not a fluke.

--I don't take vitamin A supplements, except what is in my multivitamin. Switched to new one with only beta-carotene, a while back, no preformed Vit. A. Still stayed high. Don't eat foods with a lot of vitamin A, except cheddar. Which even then I was getting less than half the tolerable upper limit (TUL) every single day even with full RDA of preformed from multivitamin. But now, beta-carotene only, cheddar every few days as snack. Mostly eat frozen and microwaveable foods and Vitamin A is negligible on nutrition information.

Online sources all say high vitamin A takes thousands of mcg over TUL for an extended period of time before it gets to potentially toxic levels. Can only conclude it is not getting metabolized enough. since I am way below TUL and hardly getting preformed Vit. A. Plus the carotenemia factor.

Forget what I wrote below here before going back and trying to make simpler a couple times. Probably has other relevant info but if you already made it this far, that's farther than expected anyway.

It "seems" like my vitamin A is not metabolizing properly, which suppresses beta-carotene metabolism. If my limited understanding is correct, CYP3A4 is induced by the body to metabolize Vitamin A levels if they get too high?

CYP3A4 is the bane of my existence and I suspect Vitamin A is the culprit. Seems like whatever regulates vitamin A has become sensitive not just to levels, but simply to changes to CYP3A4. Anything that is purported to inhibit 3A4 seems to cause a rebound reaction of increased activity.

Carotenemia increased in 2022. I wipe my face often do to naturally oily skin, and oil tends to be yellow tinted. My understanding is beta-carotene can come out the oil pours. And tends to wax and wane with the color of my head. Eyes and gums are not yellowed. AST and ALT and blood tests show most things are normal.

Had my vitamin A added to blood test in I think summer 2024, which was elevated at like 80, but not concerning. Meanwhile my LDL had been going up every blood test because new meds induced my 3A4 and simvastatin stopped working. LDL went from 80 summer 2023 to 160 summer 2025. Had been successful on simvastatin since 2004. Asked my endocrinologist to switch me to pravastatin that does not affect P450 enzymes. Lazy and could not bother to look up equivalent dosing and just gave me same 20 mg dose when they are 2 to 1 and should have been 40 mg. Vitamin A was now 114. Does say there is a link between vitamin A and LDL levels as LDL is one of it's transports. More transport, more room for Vitamin A I guess? 6 months later, LDL only down to 146 and Vitamin A still at 107.

Skipping details but events in November screwed up my balance of meds and ER docs couldn't be bothered to check meds and supplements and gave me a steroid shot and Cipro which both mess with 3A4. So it seems like Vitamin A countered and induced 3A4 more, Making my 4 meds metabolized by 3A4 far less effective, and my very difficult life, very very difficult.

I have 4 meds currently that are primarily metabolized by CYP3A4.

Have had mild carotenemia going back a number of years. At first could not understand why my normally pasty white complexion retained a slight tan on my head and neck during the winter. When I don't even go outside in the summer.

Have a slight pink tone and when I do something that gets rid of it, the yellow/orange is unmistakable.

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u/Ill_Possible_7740 — 3 days ago

Selling Fidelity ETF from Vanguard brokerage account. When does it select the selling price?

I expected selling shares of my ETF from another vendor would use the price when transaction was submitted. But it looks like it had used the closing price instead? Is that right?

Does selling Vanguard ETFs capture the price when transaction is submitted or closing? Assuming sold during trading hours.

Does all after hours sales use the opening price the next day?

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u/Ill_Possible_7740 — 10 days ago

Identification of unknown chemicals, 2nd attempt.

I'm posting again as everyone got hung up on the drama and the details of the situation. Not a single person could answer the actual question. Seeing if there is a single person with professional integrity and able to answer the question. Just for the sake of argument, assume what I say is accurate and focus on the question please. Consider it hypothetical if you have to.

If you want to comment on the drama, mock me more, or read all the drama. Then please post on the original post and not clutter this one.
https://www.reddit.com/r/industrialhygiene/comments/1u7rrw1/need_to_identify_2_unknown_industrial_chemicals/

Things escalated with my downstairs neighbor. Last November he sprayed 2 chemicals into my condo and car over the course of 6 days. The semi-volatile one was sprayed only 1 time in my kitchen through the screen door when open. The other pretty much turns to vapor instantly when sprayed, each day and in my car. Which was sprayed 1 other time 2 months prior.Tentatively think the best candidates are unmixed solvents used in auto shop painting / coatings. Not going to explain that here, no way to be sure without testing.

**I am trying to find out what would be testable so I can have a more informed conversation with consultants. And may need to check certain things ahead of time based on the answer. If I can get anyone to answer. I know it might be expensive, insurance would cover it. And I need it for insurance to begin with.

What can I test if an air sample is not likely to pick up something this long afterward?

I have some guesses but everyone gets hung up on everything else and can't be bothered to answer the actual question.

In general, any household items that are most likely to absorb chemical fumes and retain them that can be tested?

Some guesses?:

  1. My P100/activated carbon cartridges on my respirator that filtered both chemicals.

  2. One chemical was sprayed before the 6 days that chased me off. For 2 months anytime I left a cup of water on my coffee table in the living room. Within an hour it tasted tainted by a chemical. If I leave out distilled water and it tastes tainted. Could that then be tested?

  3. Bars of bath soap in their package were softened around the outer portion. If still soft when I go back then would that be an option to be tested?

  4. Have to double check but looked like my fish oil supplement had the gel caps start to leak after being exposed. Can't be sure it wasn't just my blurry eyes, but if it wasn't just my eyes, can they test that?

  5. I know cardboard boxes absorbed the chemicals due to putting some in my room a month later and off gassing enough to be affected. Would a sample of cardboard be worth a try?

  6. I know leather a couple months later was still tainted?

No matter what people think of me. If there is even a chance that this isn't all just in my head, then other people may be at risk. My other neighbors where fumes could have reached. My wife was out of state at the time as a live in Nanny. She has gone home a few times to bring stuff to where she is staying. Potentially exposing a 6 year old, 15 month old, and 3 month old. She doesn't understand that because she couldn't smell anything when she went back a few times starting a couple months later. That food in our kitchen is not automatically safe and had eaten some things. Would also like to know if I need to look out for other long term side effects that haven't hit me already.

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u/Ill_Possible_7740 — 12 days ago

Need to identify 2 unknown industrial chemicals sprayed into my condo last November.

Any idea what may absorb and retain industrial chemicals like these, which could be tested 7 months later? List of my ideas at the bottom if you want to skip to it. Maybe if there are some candidates I might get more responses from places I reach out to. Plus, I can go home and check up on things that might be usable if I know what to look for. Everything I own and my home was exposed, should be a lot to choose from.

I could do a separate post just on observed chemical properties, acute physical and neurological effects and what not if that might narrow down some candidates?

Tenant who did this lived on the first floor. My condo is the 2nd and 3rd with attic above. I know having been a long time since November makes things harder. But, explaining the delay does not add any benefit to the situation so not going to get into it.

Criminal lived (since evicted) downstairs and we had issues. They sprayed an industrial chemical into my home Sept. 1st that caused my ears to ring for a month and a half. And when I left a glass of water on my coffee table, within an hour it would taste chemically tainted over the next 2 months. Was later sprayed in November at least once a day into my home for 6 days straight and at least twice into my car. Through the gaps between framework of home and firewall. Builders sealed nothing so something that expands like a thousand times when sprayed easily expands into home. Also more than once through front window.

November he sprayed it late night on the 6th. He knew I would open my windows like I always due (from pot smoke and spraying chemical). He or one of his associates then sprayed a different chemical through the screen door in my kitchen. Which was much more nasty. Only sprayed that one one time. Kept spraying the other one.

I suspect good candidates for these chemicals would be those available to an auto/paint shop as his criminal activity involved vehicles and had referred to "the shop" before. For all I know, they could be pesticides. But, automotive paint shop has a lot of good candidates. Like the nasty one had chemical properties observed, physical effects, and cognitive effects that are consistent with isocyanates when searching/filtering candidates with google AI. Not considered reliable, just convenient. Does give an idea the kind of people I am dealing with though. Did attempt to clean most of that nasty chemical. In the morning sunlight coming through the window. Could see a shiny clear coating on my linoleum floor. I sprayed it with white vinegar and let it sit for a few hours. Then mopped up with ammonia based floor cleaner. Didn't go through stuff to the side that might have been hit. That was the 7th. Could still smell it on the 13th before I left the state. Other people could not. But the ordeal had induced hypersensitive smell (hyperosmia) regarding chemicals so I still could. It went away but I seem to have permanent Multiple Chemical Sensitivity (MCT) so it can be retriggered.

Had bought a home air quality tester on Amazon. I know nothing about these so have no idea how calibrated and if it should pick up these kind of chemicals or not. I did not indicate any issues. Had seen people say these kind of things are practically useless. No idea if they are right. Maybe this thing is junk or not calibrated for these kind of chemicals. Or maybe they weren't VOCs?
https://www.amazon.com/dp/B0FBM8ZL9B?ref_=ppx_hzsearch_conn_dt_b_fed_asin_title_2

Been contacting different organizations including places with Industrial Hygienists that do residential work. Assuming off gassing not likely to work at this point for collection and testing. I need to figure out other things I can test potentially.

Some ideas of my own?
--The Activated Carbon / P100 cartridges I had on my respirator? Were also used a few times to filter out pot smoke blown into my home. They were still highly exposed to the 2 chemicals though.
--Can leave glasses of distilled water in kitchen and other rooms and see if they taste tainted after a few hours. If so, then one or both are still off gassing. Then could water be tested?

For the one sprayed multiple times:
--Chrome around my car's windows outside and hinge between front seats inside. Reacted with chrome to make the surface have a lite rainbow effect. Can probably scrape off a sample. May narrow chemicals that can react based on sample result?
--Irish Spring bath soap bar still in paperboard package. When I took one out, the outer portion was softened by the repeatedly sprayed chemical that also penetrated the packaging. If another bar was still softened, could it be tested to find out what caused it?
--3 or 4 weeks after leaving the state. Put a few boxes I had supplements in from home into my bedroom I am staying in. Woke up a few hour later with skin and throat reacting to off gassing. Cardboard boxes may be something that soaks up fumes?
--Had a new leather wallet that was sprayed in my car. A month or so later wiped it with rubbing alcohol and left it on a tall dresser. Everytime I walked by it for a week or so, it irritated me. From what I read it can cause VOCs to come out of what they are absorbed into. Rubbing alcohol alone doesn't have the effect. Maybe leather might absorb and retain chemicals?
--Left fish oil gelcaps at home. looked like the bottle was penetrated and made the gelcaps leak. But have to double check it wasn't just due to blurry eyes playing tricks on me. If did leak, testable for chemicals?

--Had picked up my Adderall prescription which was in the car when sprayed. Then in my contaminated coat pocket. The brown prescription bottle bothered my hand every time I picked it up afterward. I threw out the bottle and put the Adderall into a plastic bag. Last month I tried it due to constant shortages. After a couple days my ears started ringing again so assume they are tainted. The exact ingredients are available online. If that makes any difference regarding something that seems to have absorbed it that may give an idea for something else based on it that might absorb and retain? Think mentioning Adderall scares people off right away.
FD&C BLUE NO. 1, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, CORN STARCH
Amphetamine or D-amphetamine salts in Sulfate, saccharate, or aspartate monohydrate forms.

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u/Ill_Possible_7740 — 19 days ago

Anything exist that can be sprayed on reclaimed wood 2X4s contaminated by marijuana smoke, that can cause tar/resin to biodegrade and not be a problem?

As a long shot, is it possible that there is some spray or fogger that could attenuate the issue of smoke residue/resin/tar from pot smoke on reclaimed untreated wood. Without having to physically scrub everything?

[Edit, many places environmental contractors that do IH work also do smoke remediation and some deal with pot smoke. So, figured I'd give it a shot. I do have an industrial chemical issue to post about but haven't gotten to posting that one yet. The issue with my floors started right above my downstairs neighbors unconnected bathroom fans that they blew the pot smoke into and spread from there. No issue with my floors, walls and everything else that changed the previous 35 years. I watched this issue grow and grow over the course of a year. All the air goes up and out through the attic. And those attic trusses were affected too. I had spent many many hours doing renovation up there since 2020 and have lived there for 20 years. Assed the image below. ]

Marijuana smoke/tar/resin collected on the wood framing and subflooring of my condo. Trusses between me and the downstairs neighbor, between my floors, in the attic, and framing behind walls are all contaminated. As you can imagine, it would be hard to reach everything and scrub with alcohol etc.

Some things will be reachable as I will probably have to replace my entire downstairs floor and subflooring. Aside from the negligent builders not connecting the bathroom fans to the ducts so it blew all the air through and around my place. The wrongly connected clothes dryer duct got detached somewhere and provided moisture that was attracted and retained by the tar/resin. And the cheap gypsum based self leveling concrete absorbed the moisture through the subfloor and degraded. Floor sank between trusses. Not sure just how affected trusses are as of yet. Does appear they have also sagged in some places. So, aside from future off gassing of chemicals from the smoke and whatever happens to tar and resin over time. Can't have something that attracts and retains moisture remaining in place when there is no way to control the moisture levels. Especially with strong winds coming off the water nearby and a home that leaks air like a civ.

https://preview.redd.it/kun0vd1f1s6h1.jpg?width=2046&format=pjpg&auto=webp&s=030eb96aa6b3f15b7ba1244681859fa88bf07f05

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u/Ill_Possible_7740 — 24 days ago

Hail Mary idea to try that probably won't work for most people, but who knows....

Hail Mary idea to try that probably won't work for most people, but who knows. I've gotten lucky before...

TL;DR; Try taking a tablespoon of powdered sugar or table sugar mixed in water taken with Adderall IR generic that is mediocre or doesn't work for you relative to a good brand that did. See if it makes any difference at all or not. Worry about diabetes later LOL.

There are a number of issues with drugs. I personally think the decades old issue with most generics not significantly crossing the BBB to not yet be studied. As the various excipients they use aren't "supposed" to affect the BBB and API crossing it in any significant way. But they do.

I noticed the Generic Adderall IR brands with a history of working, and those with being mediocre generally compared to others. All had high glycemic index excipients. i.e. some form of sugars that are readily available and efficient bioactively. Most did not. A couple others that suck did. But, the ingredients listed for drugs don't provide the proprietary amounts of each. So I have no idea if they had a lot or very little by comparison.

Carbohydrates can make the BBB more penetrable in higher concentrations. It's not "supposed" to make a difference for drugs at smaller concentrations. So, I tried adding powdered sugar to the water I took my Elite brand Adderall IR to see if it might make it work better. For me, Elite is the next best after Sandoz or Teva. But, is a significant enough difference to prefer the other 2. The sugar did increase effect to a noticeable amount although still not quite as good as Sandoz or Teva for me. May have nothing to do with the API crossing the BBB and might just be the added energy quickly afforded the brain. But, for me, it lasted all day and not just a short time for sugar.

[ Extra extraneous info below you can skip if you made it this far and feeling antsy. ]

Table sugar. tsp = 4 grams, tbls = 12.
By comparison, a 12oz can of soda has about 40g of sugar. Or 10 tsp or 3 1/3 tbls.
So, the experiment with 1 tbls of sugar would equal 3/10s of a can of soda. Doesn't sound so bad that way.

Elite is the exact same manufacturer and formulary of the pre-summer 2022 Lannett people often liked a lot. Lannett only did the marketing and Elite dropped them and decided to market it themselves after the summer of 2022.

A possible big factor for me that others may not have. I take a combined medication approach that additionally has armodafinil, strattera, guanfacine, and caffeine pills. So, obviously more variables with unknown +/- or neutral factors. Those other meds only work for me due to damage already done and needing the releasing agent activity of adderall that other ADHD meds do not have.

If by chance it did work to any significant amount.

  1. Adjust the amount of sugar till you find the least effective amount needed.
  2. Then, would need to weigh the long term added sugar. And the fact that Adderall (amphetamines in general) can raise cortisol levels which can increase glucose in blood and increase insulin resistance. It is not clear if it is significant enough or not to be a contributing factor for someone susceptible to developing diabetes or not. I'm already diabetic and is well controlled by Jardiance + Mounjaro so it doesn't affect my total glucose levels significantly. But, I am not everybody so...think I am about to pound a box of junior mints that has been staring at me for the last hour.
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u/Ill_Possible_7740 — 1 month ago

Downside mid '90s newschool hardcore

The 90s saw hardcore go in a ton of directions. Downside were a newschool hardcore band with hip hop influence. Some bands went harder and more aggressive. But downside instead was a fun band that people could easily dance to. They did a single cassette demo. I forget the year, but they played their last show at The Boiler Room in New Britain, Connecticut. Opening for Clutch.

Often people these days refer to newschool bands as old school (Biohazard, Snapcase, Strife, etc.). It's been 30 years. Maybe we should start calling them middleschool? LOL

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u/Ill_Possible_7740 — 2 months ago

Advice for finding companies or labs that can test for unknown commercial chemical contamination in a residential home. Especially in north eastern NJ.

Jersey City, NJ. Criminal neighbor that lived in the condo below me sprayed commercial chemicals into my home and car for 6 days. There were most likely 2 different ones. Definitely 2, but can't confirm if there was any more than that. So, basically my home and everything I own is contaminated. I haven't been home in over 6 months.

Looking for places that won't try to take advantage and rip me off or over charge. As well as reliable and competent. This is NJ afterall. Any one who's lived in north east NJ knows why I'm complaining.

  1. Option 1, company that can come in and field test the air for unknown chemicals with some kind of chromatograph or similar equipment. Chemical sniffer.
  2. Option 2, a lab that I can send stuff to be tested.

As far as labs go, I'm waiting to hear back from the Rutgers lab that has what I think is the right equipment. Emailed them. No reply for 2 days so far. Will try to call if I get the energy.

Looked up what kinds of equipment can field test for unknown chemicals. Tried to find companies that have them. Basically not used for residential projects at the companies I found with them so far.

Most places I came across that do chemical testing, send to a lab to test for VOCs. I don't know if they were VOCs or not which makes it unreliable if it doesn't detect something.

Contacted the Association of Vapor Intrusion Professionals. No help Nor was JCPD, state EPA, HAZMAT, state and local departments of health and human services, insurance company, NJ dept. of community affairs.

Neighbor and his associates most likely are involved with a chop shop so my best guess is autoshop related solvents. One is extremely volatile and near instantly turns to vapor. The other was likely semi-volatile as it left a clear film on the kitchen floor I could see when the sunlight came into the window at an angle in the morning. First thought was VOCs. But I bought a home air monitor off Amazon with a VOC sensor and detected nothing. Unreliable but convenient, I gave google AI a shot for tentative quick and easy info. It did say there are some VOCs that may not be detected as they are kinda off on the side so to speak. Hail Mary candidate for the semi-volatile one is an isocyanate. Has the physical properties of the chemical, the physical reactions to it, and the cognitive reactions, the permanent chemical sensitization, rapidly kicking off my Cutaneous T-Cell Lymphoma activity that I believe was being held in check by Mounjaro for the previous 3 years. And said it may not be detected by VOC sensors for some reason that I forget off hand. Maker of my air quality monitor said they can't say if it would detect an isocyanate or not since they were not tested against it. Easily detects rubbing alcohol so I do know it is working.

Could potentially be some kind of pesticides but didn't go that far down that path. Do know he and his wife were from Brooklyn. And there were issues in brooklyn with pesticides being sold illegally and may have been used in crimes. But, Brooklyn is a well populated place so that would be highly speculative and can't assume it. Just can't write it off either.

The chemicals were chosen for a reason. By the time the cops get there, the second one would air out and they wouldn't be able to smell it. But, I was sensitized by repeat exposure and able to. Didn't realize I had developed Multiple Chemical Sensitivity and Hyperosmia till I got out of state and dish soap and rubbing alcohol were over powering with their smell. Yet could not smell a sulfur based supplement that had gone bad, sticking my nose in the bottle. While my father could smell it from over 10 ft. away. And my step mother literally gagged when she smelled it. I took one before that.

The cops could have smelled the other chemical, if they weren't useless. Skipping that whole explanation. Cleaned up the semi-volatile one as I assumed my neighbor was done with his crap and wanted to reduce potential issues from it. If I knew I'd end up needing to lab test it, I would have left the residue on the floor or tried to collect a sample first. But, 6 days later I could still smell it anyway.

Research is very difficult as my life was destroyed twice over before having to deal with my neighbor for over a year. Then the longer chemical assault (had sprayed some before but not like those 6 days). Anyways, threw a bunch of stuff thrown further out of whack physiologically that adds onto being cognitively disabled even before these events.

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u/Ill_Possible_7740 — 2 months ago

Opinion request. What product would you use to kill poison ivy that has the least chance of environmental impact?

Looking to go genocidal on poison Ivy in my neighborhood. There are several sprayable products that claim to be safe around pets and water. But, if there is one or more that people with an environmental science background would tend to prefer. I'd rather use one of those. What would you use?

Last time my father killed some poison ivy, it killed off half the turtle population in our pond. Also, poison ivy is mixed with other plants, grasses, and trees up and down my neighborhood. I know it is not possible to only hit the poison ivy leaves so if one product is more sparing of other plant life than another. That would be optimal. Assuming the options would be safe for dogs that get walked by these areas daily and other animals that may come into contact with it.

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u/Ill_Possible_7740 — 2 months ago

Anyone who can rumble, also born with exceptional hearing, or high CRT monitor flicker threshold?

After 50+ years, just found out about controlling my "Tensor Tympani" muscles is how this works, and that other people can do it too. Assumed others could. Finally found people who know WTF I am talking about!!

Have zero idea if there is any correlation between any of these things at all. Just figure if they were a cluster of things for me, maybe they are for others too, or not.

  1. Can rumble ears at will

  2. Better than average hearing, may even perceive something if not able to identify something soft enough as a sound.

  3. CRT monitors were set at 60Hz by default. Yet, on a white screen could perceive flicker up to 85Hz. 60 to 75 Hz wasn't subtle. Looked like the monitors were broken they was so bad.

  4. Less noteworthy, but mine as well throw this in as it goes with number 3. Strobe lights suck.

  5. Can anyone else sometimes hear low frequency rumbling or just low frequencies in general that others don't pick up on?

[ Optional extraneous anecdotes and explanations below ]

I can rumble my ears as long as I want, can go louder or softer. Not totally smooth transitioning up and down, louder and softer in intensity. But can do it well enough (I'm sure we could be smooth with it if practiced). Can pulse beats with varying intensities like following a rap or thrash metal song in my head. Haven't tried to master it. Just used it often enough.

As a kid in the 80s they did yearly hearing tests. And I could always if not hear, but perceive 2 to 3 tones softer than what they expected for normal hearing. Made it hard for kids to sneak up on me. Which made me understand the old saying that you could never sneak up on an indian. Because living in nature and needing fine tuned hearing to identify danger or prey for hunting, they probably developed good finely tuned hearing. That didn't have the noise of the western world to ruin it. Totally ruined it in middle school and regretted it the rest of my life, so far.

CRT monitors, if you're that old. A white screen up to 85hz I could still perceive flicker. Looking straight on. I know peripheral vision is more sensitive to motion, which is why whenever I was trying to see if something was moving or not, I'd turn my head and look near it so peripheral vision would pick up something moving or not. But, staring straight in front of a CRT monitor, it was still flickering. When I bought my first computer, first thing I looked up on the internet was how to stop flicker on a computer monitor. Especially since I paid extra for a good one since I assumed it had less chance to be an issue. As a software engineer. I refused to discuss anything on another person's computer till they turned up the refresh rate. This wikipedia article has a name for it. "Flicker fusion threshold"
https://en.wikipedia.org/wiki/Flicker_fusion_threshold

Strobes lights. Even before they started reducing rates to not trigger epileptics. (late '90s) they were not smooth. Eyes and/or brain were just on another frequency and could not mesh. If strobes went on, I'd take a break from the pit. (dance floor for those non hardcore punks or metalheads). Was actually kind of a safety issue as I couldn't see where things were and may not be able to get out of the way of someone else. Or might unintentionally clock someone else.

Not 100% sure it's not just something wrong with me vs. actually perceiving something. Live in an urban area where there is potential for low frequency stuff. Notice when things are quiet enough, overnight especially. Lots of highways, trains, construction, industrial zones, international airport, @#$%$#!s who blast their car stereo at literal concert levels in the middle of the night at pop up parties. Sometimes notice physical vibrations that I assume are transmitted through the ground, and vibrate enough to be perceived in a second floor condo. Freight train is one source. But, quite often I don't know what the source is. Then again, wife didn't notice the minor earthquake we had in NJ a few years ago. "How did you not notice that earthquake?". She didn't notice the aftershock either. When I found out it happened in "Tewksbury". I left out the fact that that was the name of an ex girlfriend, who had boobs the size of her head. Wow, that really devolved pretty fast. Even for NJ.

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u/Ill_Possible_7740 — 2 months ago

[Edit, I could have phrased it better. I am looking for an existing app recommendation to find a bluetooth tracker]

Trying to determine if there is a bluetooth tracker in my car or not. Some built in feature on my pixel phone detected one but didn't see any way to determine where it was. I hit the feature that is supposed to make it sound off, but after that I didn't detect it. Could be a custom feature to better prevent it from being found for all I know. Or a false reading from the start. Need a better app that can follow the signal strength if one is detected.

Problem is, don't trust apps in general so hard to determine which are good and which to avoid. Hence, ask people who may know better than I.

I do have a legit reason to believe my car could have a tracker. That whole story is not beneficial to explain it all. Will say, tracker would be from an organized criminal group involved in stealing cars and other things. They do have a FOB relay and were able to get in my car at least 2 times. So their tracker may be more sophisticated than a run of the mill criminal.

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u/Ill_Possible_7740 — 2 months ago