u/Tricky-Dare1583

As the title states, I believe I may be deficient in magnesium or at least insufficient now due to high does vitamin d supplementation which started in May.

I was diagnosed with vitamin D deficiency on May 10th (27 NmoL) and I was prescribed 7 weekly doses of 40,000 IU to take once a week - I finished around June 20th, then I went to Mexico from June 22nd until July 3rd.

I fell ill towards the end of the holiday and ended up with diarrhoea for two weeks, which is also known to deplete magnesium - the last 10 days I’ve experienced loads of symptoms that overlap with potassium and magnesium.

I also had a b-12 injection on July 8th and that’s when symptoms seemed to ramp up.

Recovered to 95-100% Twice After Nitrous Oxide Neuropathy, But Now Experiencing My Most Widespread Flare Yet – Looking for Advice Before My First Neurology Appointment

I’m 29 and developed neurological symptoms after prolonged nitrous oxide abuse. My last use was in September 2024, so I’ve been in recovery for just under two years. Some of you who I have spoke to will have seen my posts in previous months and years about my progress.

The reason I’m posting is that I’ve actually recovered extremely well on two occasions, reaching what I’d describe as 95-100% of my normal baseline, but I’ve also experienced two significant setbacks.

The first was in September 2025 after playing my first full 11-a-side football match in over a year. I’d been comfortably playing 7-a-side weekly, but doubling my exercise load triggered a flare that lasted around six weeks before gradually settling with B12 injections and stopping folate tablets. I believe I feel victim to folate trap at the time.

From November until March, while receiving fortnightly hydroxocobalamin injections, I had my best period since becoming ill. I was consistently around 97-100%, walking long distances, working normally and playing football with very few symptoms.

Earlier this year I returned to monthly B12 injections, and routine blood tests also found I was vitamin D deficient. I completed a course of 40,000 IU vitamin D weekly, which caused many of my neurological symptoms to return.

Thankfully, after finishing treatment I quickly improved back to around 95%, as long as I didn’t overexert myself or drink too much alcohol. I also noticed that some symptoms had improved such as fatigue, energy and strength.

I then travelled to Mexico (22 June-3 July). I felt great throughout most of the holiday, walking miles every day, doing excursions and generally living normally with very few neurological symptoms.

Towards the end of the trip I developed diarrhoea, nausea and fatigue, which I assumed was a gastrointestinal illness. My stool PCR later came back negative, although it was taken around two weeks after symptoms started.

I had another B12 injection on 8 July, and since then my neurological symptoms have increased dramatically.

My current symptoms include:
widespread burning nerve pain (my biggest concern)
tingling
increased fasciculations/twitching
brain fog
dizziness/light-headedness
intermittent vertigo (especially when lying on my left side)
left-sided headaches
increased sweating and a higher heart rate than usual when walking
occasional visual disturbance where stationary objects appear to move in a wave-like pattern after staring at them
diarrhoea that is improving but still hasn’t completely resolved

The pain itself is only around 1-4/10, but the frequency is now around 6-8/10, which is the highest it’s been since this all started. The biggest difference this time is that I’m getting burning and nerve pain in areas that have never previously been affected.

The good news is I still have normal strength, I’m walking normally and I’m sleeping reasonably well, so it’s mainly the sensory symptoms that have flared.

Around the same time I also switched from fexofenadine to cetirizine after returning home because I ran out of my prescription, and I’ve been eating much less than I was on holiday.

Because several things changed at once, I’m unsure whether this flare is related to:

the gastrointestinal illness and electrolyte loss/imbalance?

restarting B12 after a six-week gap?

recent vitamin D treatment?

changing antihistamines?

under-eating?

or simply several factors occurring together?!

I finally have my first neurology appointment this Wednesday after waiting around nine months, and I really want to make the most of it.

My main questions are:

Has anyone experienced a major flare after recovering to 95-100% from nitrous oxide neuropathy (or another neuropathy)?

Has anyone had worsening neuropathy after a gastrointestinal illness?

Has anyone noticed temporary worsening after restarting B12 injections?

Does this sound consistent with post-infectious nerve irritation or small fibre neuropathy?

Could I have developed another neurological condition alongside my original neuropathy?

The reason I ask is because I’m now experiencing burning and nerve pain in places that have never previously been affected, and the frequency is higher than it’s ever been:( Has anyone experienced something similar?

Are there any investigations or tests I should ask my neurologist about to help rule out other possible causes of my symptoms?

For example, tests for small fibre neuropathy, autonomic dysfunction, autoimmune conditions or anything else that people have found useful.
Is there anything else you’d recommend I discuss during my appointment?

I’d really appreciate hearing from anyone who’s experienced something similar. Recovering twice to almost normal and then suddenly feeling like I’ve gone backwards has been pretty discouraging.

I’m hoping this is another temporary flare rather than permanent progression, but I want to go into my neurology appointment as well prepared as possible.

It’s a killer being in this position - I really thought by this time of year I’d be firmly in the 97-100% range regardless of what life threw at me :(

Thanks for taking the time to read this post, all feedback is welcomed 🙏💙

Recovered to 95-100% Twice After Nitrous Oxide Neuropathy, But Now Experiencing My Most Widespread Flare Yet – Looking for Advice Before My First Neurology Appointment

I’m 29 and developed neurological symptoms after prolonged nitrous oxide abuse. My last use was in September 2024, so I’ve been in recovery for just under two years.

The reason I’m posting is that I’ve actually recovered extremely well on two occasions, reaching what I’d describe as 95-100% of my normal baseline, but I’ve also experienced two significant setbacks.

The first was in September 2025 after playing my first full 11-a-side football match in over a year. I’d been comfortably playing 7-a-side weekly, but doubling my exercise load triggered a flare that lasted around six weeks before gradually settling with B12 injections and stopping folate tablets.

From November until March, while receiving fortnightly hydroxocobalamin injections, I had my best period since becoming ill. I was consistently around 97-100%, walking long distances, working normally and playing football with very few symptoms.

Earlier this year I returned to monthly B12 injections, and routine blood tests also found I was vitamin D deficient. I completed a course of 40,000 IU vitamin D weekly, which caused many of my neurological symptoms to return.

Thankfully, after finishing treatment I quickly improved back to around 95%, as long as I didn’t overexert myself or drink too much alcohol.
I then travelled to Mexico (22 June-3 July). I felt great throughout most of the holiday, walking miles every day, doing excursions and generally living normally with very few neurological symptoms.

Towards the end of the trip I developed diarrhoea, nausea and fatigue, which I assumed was a gastrointestinal illness. My stool PCR later came back negative, although it was taken around two weeks after symptoms started.
I had another B12 injection on 8 July, and since then my neurological symptoms have increased dramatically.

My current symptoms include:
widespread burning nerve pain (my biggest concern)
tingling
increased fasciculations/twitching
brain fog
dizziness/light-headedness
intermittent vertigo (especially when lying on my left side)
left-sided headaches
increased sweating and a higher heart rate than usual when walking
occasional visual disturbance where stationary objects appear to move in a wave-like pattern after staring at them
diarrhoea that is improving but still hasn’t completely resolved

The pain itself is only around 1-4/10, but the frequency is now around 6-8/10, which is the highest it’s been since this all started. The biggest difference this time is that I’m getting burning and nerve pain in areas that have never previously been affected.

The good news is I still have normal strength, I’m walking normally and I’m sleeping reasonably well, so it’s mainly the sensory symptoms that have flared.

Around the same time I also switched from fexofenadine to cetirizine after returning home because I ran out of my prescription, and I’ve been eating much less than I was on holiday.

Because several things changed at once, I’m unsure whether this flare is related to:
the gastrointestinal illness
restarting B12 after a six-week gap
recent vitamin D treatment
changing antihistamines
under-eating or electrolyte changes
or simply several factors occurring together
I finally have my first neurology appointment this Wednesday after waiting around nine months, and I really want to make the most of it.

My main questions are:

Has anyone experienced a major flare after recovering to 95-100% from nitrous oxide neuropathy (or another neuropathy)?

Has anyone had worsening neuropathy after a gastrointestinal illness? Especially if electrolytes have been depleted.

Has anyone noticed temporary worsening after restarting B12 injections?

Does this sound consistent with post-infectious nerve irritation or small fibre neuropathy?

Could I have developed another neurological condition alongside my original neuropathy?

The reason I ask is because I’m now experiencing burning and nerve pain in places that have never previously been affected, and the frequency is higher than it’s ever been. Has anyone experienced something similar?

Are there any investigations or tests I should ask my neurologist about to help rule out other possible causes of my symptoms? For example, tests for small fibre neuropathy, autonomic dysfunction, autoimmune conditions or anything else that people have found useful.

Is there anything else you’d recommend I discuss during my appointment?

I’d really appreciate hearing from anyone who’s experienced something similar. Recovering twice to almost normal and then suddenly feeling like I’ve gone backwards has been pretty discouraging. I’m hoping this is another temporary flare rather than permanent progression, but I want to go into my neurology appointment as well prepared as possible.

Thanks for reading.

My vitamin d levels were 27 NmoL on April 28th.

Could increase in vitamin d levels be contributing 4 weeks after my last dose?

Context and history:

I’m 29 and developed neurological symptoms after prolonged nitrous oxide abuse. My last use was in September 2024, so I’ve been in recovery for just under two years. I’ve actually recovered extremely well on two occasions, reaching what I’d describe as 95-100% of my normal baseline, but I’ve also experienced two significant setbacks.

The first was in September 2025 after playing my first full 11-a-side football match in over a year. I’d been comfortably playing 7-a-side weekly, but doubling my exercise load triggered a flare that lasted around six weeks before gradually settling with B12 injections and stopping folate tablets. Suspected folate trap.

From November until March, while receiving fortnightly hydroxocobalamin injections, I had my best period since becoming ill. I was consistently around 97-100%, walking long distances, working normally and playing football with very few symptoms.

Earlier this year I returned to monthly B12 injections, and routine blood tests also found I was vitamin D deficient.

Vitamin D:

I completed a course of 40,000 IU vitamin D weekly, which caused many of my neurological symptoms to return. Thankfully, after stopping treatment I quickly improved back to around 95%, as long as I didn’t overexert myself or drink too much alcohol. Started 10 weeks ago and finished around 4 weeks ago.

I then travelled to Mexico (22 June-3 July). I felt great throughout most of the holiday, walking miles every day, doing excursions and generally living normally with very few neurological symptoms.

Towards the end of the trip I developed diarrhoea, nausea and fatigue, which I assumed was a gastrointestinal illness. My stool PCR later came back negative, although it was taken around two weeks after symptoms started.
I had another B12 injection on 8 July, and since then my neurological symptoms have increased dramatically.

My current symptoms include:
widespread burning nerve pain (my biggest concern)
tingling
increased fasciculations/twitching
brain fog
dizziness/light-headedness
intermittent vertigo (especially when lying on my left side)
left-sided headaches
increased sweating and a higher heart rate than usual when walking
occasional visual disturbance where stationary objects appear to move in a wave-like pattern after staring at them
diarrhoea that is improving but still hasn’t completely resolved

The pain itself is only around 1-4/10, but the frequency is now around 6-8/10, which is the highest it’s been since this all started. The biggest difference this time is that I’m getting burning and nerve pain in areas that have never previously been affected.

The good news is I still have normal strength, I’m walking normally and I’m sleeping reasonably well, so it’s mainly the sensory symptoms that have flared.

Around the same time I also switched from fexofenadine to cetirizine after returning home because I ran out of my prescription, and I’ve been eating much less than I was on holiday. Because several things changed at once, I’m unsure whether this flare is related to:
the gastrointestinal illness?
restarting B12 after a six-week gap?
recent vitamin D treatment?
changing antihistamines?
under-eating or electrolyte changes?
or simply several factors occurring together
I finally have my first neurology appointment this Wednesday after waiting around nine months, and I really want to make the most of it.
My main questions are:

Has anyone experienced a major flare after recovering to 95-100% from nitrous oxide
neuropathy (or another neuropathy)?

Has anyone had worsening neuropathy after a gastrointestinal illness?

Has anyone noticed temporary worsening after restarting B12 injections?

Does this sound consistent with post-infectious nerve irritation or small fibre neuropathy?
Could I have developed another neurological condition alongside my original neuropathy?

The reason I ask is because I’m now experiencing burning and nerve pain in places that have never previously been affected, and the frequency is higher than it’s ever been. Has anyone experienced something similar?

Are there any investigations or tests I should ask my neurologist about to help rule out other possible causes of my symptoms?

For example, tests for small fibre neuropathy, autonomic dysfunction, autoimmune conditions or anything else that people have found useful.
Is there anything else you’d recommend I discuss during my appointment?

I’d really appreciate hearing from anyone who’s experienced something similar. Recovering twice to almost normal and then suddenly feeling like I’ve gone backwards has been pretty discouraging. I’m hoping this is another temporary flare rather than permanent progression, but I want to go into my neurology appointment as well prepared as possible.

My vitamin D level at the time was 27 NmoL April 28th)

Recovered to 95-100% Twice After Nitrous Oxide Neuropathy, But Now Experiencing My Most Widespread Flare Yet – Looking for Advice Before My First Neurology Appointment

I’m 29 and developed neurological symptoms after prolonged nitrous oxide abuse. My last use was in September 2024, so I’ve been in recovery for just under two years.

The reason I’m posting is that I’ve actually recovered extremely well on two occasions, reaching what I’d describe as 95-100% of my normal baseline, but I’ve also experienced two significant setbacks.

The first was in September 2025 after playing my first full 11-a-side football match in over a year. I’d been comfortably playing 7-a-side weekly, but doubling my exercise load triggered a flare that lasted around six weeks before gradually settling with B12 injections and stopping folate tablets. Suspected folate trap.

From November until March, while receiving fortnightly hydroxocobalamin injections, I had my best period since becoming ill. I was consistently around 97-100%, walking long distances, working normally and playing football with very few symptoms.

Earlier this year I returned to monthly B12 injections, and routine blood tests also found I was vitamin D deficient. I completed a course of 40,000 IU vitamin D weekly, which caused many of my neurological symptoms to return. Thankfully, after stopping treatment I quickly improved back to around 95%, as long as I didn’t overexert myself or drink too much alcohol.
I then travelled to Mexico (22 June-3 July). I felt great throughout most of the holiday, walking miles every day, doing excursions and generally living normally with very few neurological symptoms.

Towards the end of the trip I developed diarrhoea, nausea and fatigue, which I assumed was a gastrointestinal illness. My stool PCR later came back negative, although it was taken around two weeks after symptoms started.
I had another B12 injection on 8 July, and since then my neurological symptoms have increased dramatically.

My current symptoms include:
widespread burning nerve pain (my biggest concern)
tingling
increased fasciculations/twitching
brain fog
dizziness/light-headedness
intermittent vertigo (especially when lying on my left side)
left-sided headaches
increased sweating and a higher heart rate than usual when walking
occasional visual disturbance where stationary objects appear to move in a wave-like pattern after staring at them
diarrhoea that is improving but still hasn’t completely resolved

The pain itself is only around 1-4/10, but the frequency is now around 6-8/10, which is the highest it’s been since this all started. The biggest difference this time is that I’m getting burning and nerve pain in areas that have never previously been affected.

The good news is I still have normal strength, I’m walking normally and I’m sleeping reasonably well, so it’s mainly the sensory symptoms that have flared.

Around the same time I also switched from fexofenadine to cetirizine after returning home because I ran out of my prescription, and I’ve been eating much less than I was on holiday. Because several things changed at once, I’m unsure whether this flare is related to:
the gastrointestinal illness?
restarting B12 after a six-week gap?
recent vitamin D treatment (started 10 weeks ago and finished 6 weeks ago)
changing antihistamines?
under-eating or electrolyte changes?
or simply several factors occurring together?
I finally have my first neurology appointment this Wednesday after waiting around nine months, and I really want to make the most of it.

My main questions are:
Has anyone experienced a major flare after recovering to 95-100% from nitrous oxide neuropathy (or another neuropathy)?

Has anyone had worsening neuropathy after a gastrointestinal illness?

Has anyone noticed temporary worsening after restarting B12 injections?

Does this sound consistent with post-infectious nerve irritation or small fibre neuropathy?

Could I have developed another neurological condition alongside my original neuropathy? The reason I ask is because I’m now experiencing burning and nerve pain in places that have never previously been affected, and the frequency is higher than it’s ever been. Has anyone experienced something similar?

Are there any investigations or tests I should ask my neurologist about to help rule out other possible causes of my symptoms?

For example, tests for small fibre neuropathy, autonomic dysfunction, autoimmune conditions or anything else that people have found useful.
Is there anything else you’d recommend I discuss during my appointment?
I’d really appreciate hearing from anyone who’s experienced something similar. Recovering twice to almost normal and then suddenly feeling like I’ve gone backwards has been pretty discouraging. I’m hoping this is another temporary flare rather than permanent progression, but I want to go into my neurology appointment as well prepared as possible.

As you could imagine, my anxiety is at an all time high, and I’m scared I’ll get dismissed or get nowhere with my neurologist.

Recovered to 95-100% Twice After Nitrous Oxide Neuropathy, But Now Experiencing My Most Widespread Flare Yet – Looking for Advice Before My First Neurology Appointment,

I’m 29 and developed neurological symptoms after prolonged nitrous oxide abuse. My last use was in September 2024, so I’ve been in recovery for just under two years.

The reason I’m posting is that I’ve actually recovered extremely well on two occasions, reaching what I’d describe as 95-100% of my normal baseline, but I’ve also experienced two significant setbacks.

The first was in September 2025 after playing my first full 11-a-side football match in over a year. I’d been comfortably playing 7-a-side weekly, but doubling my exercise load triggered a flare that lasted around six weeks before gradually settling with B12 injections and stopping folate tablets.

From November until March, while receiving fortnightly hydroxocobalamin injections, I had my best period since becoming ill. I was consistently around 97-100%, walking long distances, working normally and playing football with very few symptoms.

Earlier this year (April 2026) I returned to monthly B12 injections, and routine blood tests also found I was vitamin D deficient. I completed a course of 40,000 IU vitamin D weekly, which caused many of my neurological symptoms to return. Thankfully, after stopping treatment I quickly improved back to around 95%, as long as I didn’t overexert myself or drink too much alcohol.

I then travelled to Mexico (22 June-3 July). I felt great throughout most of the holiday, walking miles every day, doing excursions and generally living normally with very few neurological symptoms. Towards the end of the trip I developed diarrhoea, nausea and fatigue, which I assumed was a gastrointestinal illness. My stool PCR later came back negative, although it was taken around two weeks after symptoms started.
I had another B12 injection on 8 July, and since then my neurological symptoms have increased dramatically.

My current symptoms include:

widespread burning nerve pain (my biggest concern)
tingling
increased fasciculations/twitching
brain fog
dizziness/light-headedness
intermittent vertigo (especially when lying on my left side)
left-sided headaches
increased sweating and a higher heart rate than usual when walking
occasional visual disturbance where stationary objects appear to move in a wave-like pattern after staring at them
diarrhoea that is improving but still hasn’t completely resolved

The pain itself is only around 1-4/10, but the frequency is now around 6-8/10, which is the highest it’s been since this all started. The biggest difference this time is that I’m getting burning and nerve pain in areas that have never previously been affected. The good news is I still have normal strength, I’m walking normally and I’m sleeping reasonably well, so it’s mainly the sensory symptoms that have flared.
Around the same time I also switched from fexofenadine to cetirizine after returning home because I ran out of my prescription, and I’ve been eating much less than I was on holiday.

Because several things changed at once, I’m unsure whether this flare is related to:
the gastrointestinal illness?
restarting B12 after a six-week gap?
recent vitamin D treatment (started 10 weeks ago and finished 6 weeks ago)
changing antihistamines?
under-eating or electrolyte changes?
or simply several factors occurring together?!

I finally have my first neurology appointment this Wednesday after waiting around nine months, and I really want to make the most of it.

My main questions are:

Has anyone experienced a major flare after recovering to 95-100% from nitrous oxide neuropathy (or another neuropathy)?

Has anyone had worsening neuropathy after a gastrointestinal illness?

Has anyone noticed temporary worsening after restarting B12 injections?

Does this sound consistent with post-infectious nerve irritation or small fibre neuropathy?

Could I have developed another neurological condition alongside my original neuropathy?

The reason I ask is because I’m now experiencing burning and nerve pain in places that have never previously been affected, and the frequency is higher than it’s ever been. Has anyone experienced something similar?

Are there any investigations or tests I should ask my neurologist about to help rule out other possible causes of my symptoms?

For example, tests for small fibre neuropathy, autonomic dysfunction, autoimmune conditions or anything else that people have found useful.
Is there anything else you’d recommend I discuss during my appointment?

I’d really appreciate hearing from anyone who’s experienced something similar. Recovering twice to almost normal and then suddenly feeling like I’ve gone backwards has been pretty discouraging.

I’m hoping this is another temporary flare rather than permanent progression, but I want to go into my neurology appointment as well prepared as possible.
Thanks for reading.

Thanks for reading. As you can probably make out, I’m nervous due to increase in symptoms and upcoming appointment, which I’m fearful that my concerns might get dismissed :(

I’d love to hear at feedback you may have :)

Recovered to 95-100% Twice After Nitrous Oxide Neuropathy, But Now Experiencing My Most Widespread Flare Yet – Looking for Advice Before My First Neurology Appointment

Context and background information:

I’m 29 and developed neurological symptoms after prolonged nitrous oxide abuse. My last use was in September 2024, so I’ve been in recovery for just under two years.

The reason I’m posting is that I’ve actually recovered extremely well on two occasions, reaching what I’d describe as 95-100% of my normal baseline, but I’ve also experienced two significant setbacks.

The first was in September 2025 after playing my first full 11-a-side football match in over a year. I’d been comfortably playing 7-a-side weekly, but doubling my exercise load triggered a flare that lasted around six weeks before gradually settling with B12 injections and stopping folate tablets.

From November 2025 until March 2026, while receiving fortnightly hydroxocobalamin injections, I had my best period since becoming ill. I was consistently around 97-100%, walking long distances, working normally and playing football with very few symptoms. Earlier this year I returned to monthly B12 injections, and routine blood tests also found I was vitamin D deficient. I completed a course of 40,000 IU vitamin D weekly, which caused many of my neurological symptoms to return. Thankfully, after stopping treatment I quickly improved back to around 95%, as long as I didn’t overexert myself or drink too much alcohol.

I then travelled to Mexico (22 June-3 July). I felt great throughout most of the holiday, walking miles every day, doing excursions and generally living normally with very few neurological symptoms. Towards the end of the trip I developed diarrhoea, nausea and fatigue, which I assumed was a gastrointestinal illness. My stool PCR later came back negative, although it was taken around two weeks after symptoms started.
I had another B12 injection on 8 July, and since then my neurological symptoms have increased dramatically.

My current symptoms include:

widespread burning nerve pain (my biggest concern)
tingling
increased fasciculations/twitching
brain fog
dizziness/light-headedness
intermittent vertigo (especially when lying on my left side)
left-sided headaches
increased sweating and a higher heart rate than usual when walking
occasional visual disturbance where stationary objects appear to move in a wave-like pattern after staring at them
diarrhoea that is improving but still hasn’t completely resolved

The pain itself is only around 1-4/10, but the frequency is now around 5-6/10, which is the highest it’s been since this all started. The biggest difference this time is that I’m getting burning and nerve pain in areas that have never previously been affected. The good news is I still have normal strength, I’m walking normally and I’m sleeping reasonably well, so it’s mainly the sensory symptoms that have flared.

Around the same time I also switched from fexofenadine to cetirizine after returning home because I ran out of my prescription, and I’ve been eating much less than I was on holiday.

Because several things changed at once, I’m unsure whether this flare is related to:
the gastrointestinal illness restarting B12 after a six-week gap?
recent vitamin D treatment? (Started 10 weeks ago, but I finished the course 6 weeks ago)
changing antihistamines?
under-eating or electrolyte changes?
or simply several factors occurring together?!

I finally have my first neurology appointment this Wednesday after waiting around nine months, and I really want to make the most of it.
My main questions are:

Has anyone experienced a major flare after recovering to 95-100% from nitrous oxide neuropathy (or another neuropathy)?

Has anyone had worsening neuropathy after a gastrointestinal illness?

Has anyone noticed temporary worsening after restarting B12 injections?

Does this sound consistent with post-infectious nerve irritation or small fibre neuropathy?

Could I have developed another neurological condition alongside my original neuropathy?

The reason I ask is because I’m now experiencing burning and nerve pain in places that have never previously been affected, and the frequency is higher than it’s ever been.

Has anyone experienced something similar?

Are there any investigations or tests I should ask my neurologist about to help rule out other possible causes of my symptoms?

For example, tests for small fibre neuropathy, autonomic dysfunction, autoimmune conditions or anything else that people have found useful.
Is there anything else you’d recommend I discuss during my appointment?

I’d really appreciate hearing from anyone who’s experienced something similar. Recovering twice to almost normal and then suddenly feeling like I’ve gone backwards has been pretty discouraging. I’m hoping this is another temporary flare rather than permanent progression, but I want to go into my neurology appointment as well prepared as possible.

Thanks for reading. As you can probably make out, I’m nervous due to increase in symptoms and upcoming appointment, which I’m fearful that my concerns might get dismissed :(

I’d love to hear at feedback you may have :)

Since starting to increase my magnesium, calcium and potassium through foods solely, I’ve noticed an increase in muscles soreness throughout my body. The pain is not debilitating, it feels like I’ve semi-pushed myself in the gym.

I’ve been getting around 400/500 mg for magnesium and around 1000 mg for calcium.

I’m on weekly high dose vitamin D capsules (40,000 IU) and I’m 5.5 weeks in.

Is it normal to feel like this at this stage? I know vitamin d has an impact on our muscles, but I don’t know to what extent and the actual science etc

After speaking to people on here about which magnesium form to take after finding out glycinate doesn’t agree with me, I’m going to be trying magnesium citrate - 150 mg - says it’s equates to 40% of the RDA, so I’ll only be taking one a day for now.

I’ve been taking high dose vitamin D3 on a once a week basis for 5 weeks now.

People have also told me pure encapsulations is a brand that is trusted and with a good reputation.

I do get a lot of magnesium and calcium from diet already as I consume kefir (350 grams), dark chocolate and two table spoons of pumpkin seeds everyday.

Which form of magnesium is least likely to affect someone with a sensitive nervous system?

I’m 21 months into a b-12 recovery which was caused by nitrous oxide use.

I’m 4.5 weeks into treating a vitamin d deficiency with weekly 40,000 IU doses.

I’ve already tried glycinate on two different occasions for a week long, and I seem to be one of those people who can’t tolerate it 🤷‍♂️ most recently, I tried around two weeks ago for a week, stopped it and feel better since stopping it.

What I’ve noticed since stopping the glycinate, way less allergy symptoms, hardly any internal tremors, feeling unusually hot and less sweating

Curious to hear from anyone who continued making gains after the 18-month mark and beyond following nitrous oxide-induced B12 deficiency.

I’m currently 20.5 months clean from nitrous and have been completely abstinent since stopping.
Thankfully, I never lost any major function.

Early on I had some gait issues and neurological symptoms, but the gait problems resolved and I was able to return to work, travelling, socialising, and even football. Over the last year, I’ve spent long periods feeling somewhere between 95–99% recovered.

That said, I’ve continued to experience intermittent neurological symptoms throughout recovery, including:

Tingling and pins and needles

Burning and pinching nerve pain

Fatigue

Weakness/heavy limbs

Occasional internal vibrations

Mild sensory symptoms in the sole of my left foot (which remains noticeably more reactive than my right)

Most symptoms are relatively mild and transient.

The nerve pain rarely lasts long and often settles when I move around or change position.

One thing that makes me wonder whether there’s still healing happening is that I actually went around 10 months without any B12 injections (December 2024 to September 2025) and still continued to improve overall during that period.

However, after overexerting myself with a full 90-minute football match in September 2025, I experienced my biggest flare-up since the original injury.

I went back onto monthly injections in September and October 2025, then managed to move onto bi-weekly injections from November 2025 through March 2026.

During that period I felt incredibly close to 100%. In fact, I made a post back in March describing what I thought was my new permanent baseline because life felt almost completely normal again.
More recently, I’ve been correcting a significant vitamin D deficiency while also moving back to monthly B12 injections.

Around the same time, I’ve experienced a 6-week flare consisting of increased burning, tingling, nerve hypersensitivity, fatigue, weakness, and other familiar neurological symptoms. It’s been tolerable and I remain fully functional, but it’s definitely knocked my confidence.

I know recovery isn’t always linear, but when you’ve felt so close to the finish line, it’s hard not to worry that this lower baseline might become permanent or that deterioration could continue.
So I’m curious:

Did anyone continue making meaningful improvements after 18–24 months or beyond?

Did anyone have setbacks or flares late into recovery and still go on to improve?

After improving, did things take a turn for the worse and you continued to decline?

Has anyone experienced vitamin D correction temporarily aggravating neurological symptoms during recovery?

Would really appreciate hearing other people’s experiences and what you believed help you 💙

Curious to hear from anyone who continued making gains after the 18-month mark and beyond following nitrous oxide-induced B12 deficiency.

I’m currently 20.5 months clean from nitrous and have been completely abstinent since stopping.
Thankfully, I never lost any major function.

Early on I had some gait issues and neurological symptoms, but the gait problems resolved and I was able to return to work, travelling, socialising, and even football. Over the last year, I’ve spent long periods feeling somewhere between 95–99% recovered.

That said, I’ve continued to experience intermittent neurological symptoms throughout recovery, including:

Tingling and pins and needles

Burning and pinching nerve pain

Fatigue

Weakness/heavy limbs

Occasional internal vibrations

Mild sensory symptoms in the sole of my left foot (which remains noticeably more reactive than my right)

Most symptoms are relatively mild and transient.

The nerve pain rarely lasts long and often settles when I move around or change position.

One thing that makes me wonder whether there’s still healing happening is that I actually went around 10 months without any B12 injections (December 2024 to September 2025) and still continued to improve overall during that period.

However, after overexerting myself with a full 90-minute football match in September 2025, I experienced my biggest flare-up since the original injury.

I went back onto monthly injections in September and October 2025, then managed to move onto bi-weekly injections from November 2025 through March 2026.

During that period I felt incredibly close to 100%. In fact, I made a post back in March describing what I thought was my new permanent baseline because life felt almost completely normal again.
More recently, I’ve been correcting a significant vitamin D deficiency while also moving back to monthly B12 injections.

Around the same time, I’ve experienced a 6-week flare consisting of increased burning, tingling, nerve hypersensitivity, fatigue, weakness, and other familiar neurological symptoms. It’s been tolerable and I remain fully functional, but it’s definitely knocked my confidence.

I know recovery isn’t always linear, but when you’ve felt so close to the finish line, it’s hard not to worry that this lower baseline might become permanent or that deterioration could continue.
So I’m curious:

Did anyone continue making meaningful improvements after 18–24 months or beyond?

Did anyone have setbacks or flares late into recovery and still go on to improve?

After improving, did things take a turn for the worse and you continued to decline?

Has anyone experienced vitamin D correction temporarily aggravating neurological symptoms during recovery?

Would really appreciate hearing other people’s experiences and what you believed help you 💙

I’ve been on 3/4 holidays over the last 20 months or so, (my neuropathy started 20 months ago or so) and I’ve managed to tolerate them and everything that comes with holidays quite well.

I’ve been going through a flare on and off the last 3-6 weeks, as you all know, it’s non-linear, some days feel better than others.

I have a holiday to Mexico in 2.5 weeks, and I’m worried this flare might carry on and throughout the holiday as I’m currently correcting a vitamin d deficiency.

How do you guys and girls manage yourselves when going on holiday destinations far away? Is there anything in particular that helps?

I know everyone responds differently to vitamin D, both in terms of the form used and the dosage schedule, but I’d be interested to hear about other people’s experiences.

Has anyone here tried both at different times in their life:

Weekly loading doses (40,000 IU or more once per week) my current approach.

Daily dosing (5,000–10,000 IU per day)

If so, which approach felt easier on your system and why?

I’m currently taking 40,000 IU once a week for a vitamin D deficiency. I’m 4.5 weeks into a 7-week loading course and have 3 doses left to go. While I’m hoping it helps in the long run, I’ve noticed a few changes since starting treatment and I’m curious whether others found daily dosing to be a smoother experience.

I’m also looking at magnesium, as magnesium glycinate doesn’t seem to agree with me. For those with sensitive nervous systems, which forms of magnesium have you found to be the most tolerable?

I’ve been considering magnesium malate, taurate, citrate, or threonate, but I’d love to hear real-world experiences and recommendations.
Thanks in advance.

I’m curious to see what condition other people have been diagnosed with and how you manage to get through everyday?

I currently suffer from neuropathy, albeit, it’s mild enough to not usually affect my sleep, but it’s been present everyday for around 2 years or so.

Long story short, I developed a B12 deficiency from nitrous oxide abuse around 20 months ago. I’ve been completely abstinent since then and have been treating aggressively with B12.
My treatment timeline looked roughly like this:

Mid-October 2024: Hydroxocobalamin injections every other day for 2 weeks.

November 2024: 4 weekly injections.

December 2024 – September 2025: Daily sublingual B12.

During that period I gradually improved. Most days I felt somewhere between 90–99%, with my baseline probably around 95%+ for the most part.

I was able to return to normal life. I went back to work, travelling, football, socialising, drinking alcohol, etc. I still had some intermittent symptoms such as:

Nerve pain
Tingling
GI issues
Fatigue
Occasional weakness

But overall, I was functioning well.
In September 2025, I overexerted myself playing football and had a significant flare-up.

I restarted B12 injections (monthly in October and November 2025), then moved to bi-weekly injections from November 2025 until March 2026.

That period was probably the best I’d felt since becoming ill. My baseline was often 97–100%, and I was tolerating life extremely well, including:

Illness
Travel
Work
Sport
Alcohol

Even a few cocaine/alcohol binges (I know I shouldn’t have done this, but I’m mentioning it for transparency) Despite those poor choices, I generally remained stable.

In March 2026 I was moved back to monthly injections and ended up having a 6-week gap between injections (March 17th to April 28th). Even then, I only had 1–3 rough days, and they were short-lived.

At my most recent review, my Vitamin D level came back at 27 nmol/L, so my GP felt that was likely contributing to headaches, fatigue, back pain and some of the symptoms I was experiencing.

I started treatment on May 10th with 40,000 IU Vitamin D once weekly. I’ve now taken 4 of the 7 prescribed doses. Since starting Vitamin D, however, I’ve been flaring much more frequently. Almost daily I’ve experienced some combination of:

Burning nerve pain
Pinching/zapping pains
Tingling
Brain fog
Muscle and joint aches
Nausea
Increased symptom awareness

I’ve also recently stopped taking magnesium glycinate because I suspect I may be sensitive to glycine. Since stopping it, some symptoms seem to have improved, particularly:

Internal vibrations
Trembling/jittery sensations
Allergy-like symptoms
Feeling “wired”

So I’m trying to work out what’s actually going on.

My questions are:

Has anyone experienced increased neurological symptoms while correcting a Vitamin D deficiency?

Did things eventually settle down and improve?
Has anyone found that large weekly doses (40,000–50,000 IU) caused more symptoms than smaller daily doses (e.g. 4,000–5,000 IU)?

Has anyone with previous B12-related neurological issues noticed Vitamin D treatment temporarily changing symptom intensity?

Did anyone get worse and not improve?

My main worry is I won’t be able to get back to where I was in early 2026, which was basically living and tolerating normal life with minimal and short lived symptoms/flares

Any thoughts or experiences would be appreciated. 💚

Long story short, I developed a B12 deficiency from nitrous oxide abuse around 20 months ago. I’ve been completely abstinent since then and have been treating aggressively with B12.

My treatment timeline looked roughly like this:

Mid-October 2024: Hydroxocobalamin injections every other day for 2 weeks.
November 2024: 4 weekly injections.
December 2024 – September 2025: Daily sublingual B12.

During that period I gradually improved. Most days I felt somewhere between 90–99%, with my baseline probably around 95%+ for the most part. I was able to return to normal life. I went back to work, travelling, football, socialising, drinking alcohol, etc. I still had some intermittent symptoms such as:
Nerve pain
Tingling
GI issues
Fatigue
Occasional weakness

But overall, I was functioning well.

In September 2025, I overexerted myself playing football and had a significant flare-up. I restarted B12 injections (monthly in October and November 2025), then moved to bi-weekly injections from November 2025 until March 2026.

That period was probably the best I’d felt since becoming ill. My baseline was often 97–100%, and I was tolerating life extremely well, including:

Illness
Travel
Work
Sport
Alcohol

Even a few cocaine/alcohol binges (I know I shouldn’t have done this, but I’m mentioning it for transparency) Despite those poor choices, I generally remained stable.

In March 2026 I was moved back to monthly injections and ended up having a 6-week gap between injections (March 17th to April 28th). Even then, I only had 1–3 rough days, and they were short-lived.

At my most recent review, my Vitamin D level came back at 27 nmol/L, so my GP felt that was likely contributing to headaches, fatigue, back pain and some of the symptoms I was experiencing. I started treatment on May 10th with 40,000 IU Vitamin D once weekly. I’ve now taken 4 of the 7 prescribed doses.
Since starting Vitamin D, however, I’ve been flaring much more frequently. Almost daily I’ve experienced some combination of:

Burning nerve pain
Pinching/zapping pains
Tingling
Brain fog
Muscle and joint aches
Nausea
Increased symptom awareness

I’ve also recently stopped taking magnesium glycinate because I suspect I may be sensitive to glycine. Since stopping it, some symptoms seem to have improved, particularly:

Internal vibrations
Trembling/jittery sensations
Allergy-like symptoms
Feeling “wired”

So I’m trying to work out what’s actually going on.

My questions are:

Has anyone experienced increased neurological symptoms while correcting a Vitamin D deficiency?

Did things eventually settle down and improve?

Has anyone found that large weekly doses (40,000–50,000 IU) caused more symptoms than smaller daily doses (e.g. 4,000–5,000 IU)?

Has anyone with previous B12-related neurological issues noticed Vitamin D treatment temporarily changing symptom intensity?

Any thoughts or experiences would be appreciated 💚

I know I’ve posted on here a few times, but I’m so stressed at the moment due to what feels like more than one step back :( it’s my worst flare since September 😥😭

Long story short, I developed a B12 deficiency from nitrous oxide abuse around 20 months ago. I’ve been completely abstinent since then and have been treating aggressively with B12.
My treatment timeline looked roughly like this:

Mid-October 2024: Hydroxocobalamin injections every other day for 2 weeks.

November 2024: 4 weekly injections.

December 2024 – September 2025: Daily sublingual B12.

During that period I gradually improved. Most days I felt somewhere between 90–99%, with my baseline probably around 95%+ for the most part.

I was able to return to normal life. I went back to work, travelling, football, socialising, drinking alcohol, etc. I still had some intermittent symptoms such as:

Nerve pain
Tingling
GI issues
Fatigue
Occasional weakness

But overall, I was functioning well.
In September 2025, I overexerted myself playing football and had a significant flare-up.

I restarted B12 injections (monthly in October and November 2025), then moved to bi-weekly injections from November 2025 until March 2026.

That period was probably the best I’d felt since becoming ill. My baseline was often 97–100%, and I was tolerating life extremely well, including:

Illness
Travel
Work
Sport
Alcohol

Even a few cocaine/alcohol binges (I know I shouldn’t have done this, but I’m mentioning it for transparency) Despite those poor choices, I generally remained stable.

In March 2026 I was moved back to monthly injections and ended up having a 6-week gap between injections (March 17th to April 28th). Even then, I only had 1–3 rough days, and they were short-lived.

At my most recent review, my Vitamin D level came back at 27 nmol/L, so my GP felt that was likely contributing to headaches, fatigue, back pain and some of the symptoms I was experiencing.

I started treatment on May 10th with 40,000 IU Vitamin D once weekly. I’ve now taken 4 of the 7 prescribed doses. Since starting Vitamin D, however, I’ve been flaring much more frequently. Almost daily I’ve experienced some combination of:

Burning nerve pain
Pinching/zapping pains
Tingling
Brain fog
Muscle and joint aches
Nausea
Increased symptom awareness

I’ve also recently stopped taking magnesium glycinate because I suspect I may be sensitive to glycine. Since stopping it, some symptoms seem to have improved, particularly:

Internal vibrations
Trembling/jittery sensations
Allergy-like symptoms
Feeling “wired”

So I’m trying to work out what’s actually going on.

My questions are:

Has anyone experienced increased neurological symptoms while correcting a Vitamin D deficiency?

Did things eventually settle down and improve?
Has anyone found that large weekly doses (40,000–50,000 IU) caused more symptoms than smaller daily doses (e.g. 4,000–5,000 IU)?

Has anyone with previous B12-related neurological issues noticed Vitamin D treatment temporarily changing symptom intensity?

Did anyone get worse and not improve?

My main worry is I won’t be able to get back to where I was in early 2026, which was basically living and tolerating normal life with minimal and short lived symptoms/flares

Any thoughts or experiences would be appreciated. 💚

Long story short, I have a sensitive nervous system.

I started taking magnesium glycinate last Thursday and I noticed an increase in some symptoms, which I thought could be a possibility once I started taking magnesium glycinate. But then my hay-fever symptoms returned, which, I thought was strange as they have always been well controlled over the years thanks to fexofenadine (180mg) and a nasal steroid spray. I then got like this internal jittering/trembling feeling throughout my body and an increase in vivid dreams, but my sleep and Hrv seemed to be better.

I came across a post on the supplement forum speaking about how some people experience effects that can be seen and perceived as more negative when taking glycinate, I spoke to a few people and it seems like I might belong in that small group of people who don’t do so well when taking glycinate due to the glycine and the effects it has on our NDMA receptors.

So, I was wondering, which form of magnesium would you recommend other than glycinate?

And has anyone else on here also experienced different kinds of reactions to what others have described when they’ve taken glycinate.

All feedback is welcomed :) 💚

Hi everyone, my d level was 27 nmol/L on April 29th - so I’ve been on weekly supplementation since. I’ve been taking 40,000 IU once a week - I had my 3rd dose yesterday, and I have 4 more to go. I’ve been taking magnesium glycinate 120 or 240 and making sure I get the RDA from food - from the good point of view, it’s tough mentally and feels repetitive, but I know it’s beneficial for my current situation, so I’m happy to continue doing so.

Did anyone feel like they got worse before they got better? After my dose yesterday and my b-12 injection, I’ve had an increase in nerve pain, what feels like joint pain, back pain and muscles soreness.

Good chance I’ve been deficient for at least a year, as these have happened on and off, but feel more prominent in recent times.

Any feedback is welcomed :)

I will answer all questions you may have as well