u/dontkry4me

Reasoning alone cannot predict the chaotic physical world. Without a sensory and motor interface to reality, non-physical AI will not deliver the scientific and technological breakthroughs we expect.

Verastem reported a greater than 50% reduction of CA19-9 in 13 of 14 pretreated patients with metastatic pancreatic cancer treated with 900 mg of its oral KRAS G12D inhibitor VS-7375. Whether CA19-9 reliably tracks tumor burden and can predict survival is another question.

An organization can sense and act on its own, but it has always had to borrow its reasoning from the humans it employs. Palantir's ontology hands it a living model of itself, AI supplies the capacity to reason over it, and together they might give the enterprise a functional intelligence of its own.

At her 250th birthday, America is still opening frontiers. Boosters settle into the arms of launch towers, machines think at scale, and drugs reach targets once thought undruggable. The rational position is an almost delusional optimism about what Americans build next.

Rezpegaldesleukin selectively expands regulatory T cells to restore peripheral immune balance. Phase 2b trials showed impressive, deepening efficacy in AD and meaningful hair regrowth in AA.

Cue licensed CUE-221, a dual-mechanism anti-IgE antibody. A controlled Phase 2 in CSU in mainland China is expected to read out in H2 2026, after which Cue plans a global Phase 2b in food allergy.