Estrogen levels may dictate how the brain reacts to psilocybin, new animal study indicates
Study on rats indicates that estrogen may dampen the effect of psilocybin.
If this holds for humans, then a woman’s sensitivity to shrooms would fluctuate predictably through the menstrual cycle and would also be impacted by menopause etc.
Layperson article:
https://www.psypost.org/age-and-hormones-alter-how-rats-respond-to-psilocybin-2026-03-26/
Citation:
The study, “Age- and estrous-dependent effects of psilocybin in rats,” was authored by A.L. Zylko, R.J. Rakoczy, B.F. Roberts, M. Wilson, A. Powell, A. Page, M. Heitkamp, D. Feist, J.A. Jones, and M.S. McMurray.
u/wohrg — 4 days ago