The thought of becoming a girl is starting to consistently flow in my head now but just in case I want to go back, I was thinking that if I go through with this, I would microdose. Assuming no t blockers, does injecting yourself with 1 mg of estrogen biweekly still cause substantial feminizing effects? Are there any people with experiences with microdosing?
Hi i got my blood work done recently and at my trough (five days after my weekly dose 5mg) and it came back around 58 pg/ml. I told my Dr I thought those levels were bad and she said I should test my peak levels before we go up about 2 days after my injection i took the test and they came back at 453 pg/ml. I haven't seen her back yet but is this normal levels or too low? Im not sure maybe my metabolism is to fast just eats all of it super quick? (im not a scientist). Or is she trying to convince me that my numbers are fine and not being honest.
I cant find any info about how blood levels shift though the week and what is a good dose in that term. If any of you have any experience with somthing like this please let me know.
For context, I’m 16 and I’ve been wanting to transition for around 2 years now— but my mom isn’t very supportive of things like this and I don’t want her finding anything out otherwise i’d be in trouble. I want to know if there’s anyway for me to be able to somehow get estrogen in secret because I don’t want to risk telling my parents something they aren’t okay with. I know that taking estrogen after a few months can make differences that people can quickly notice, and I’m fine with that. My only issue is getting it in the first place without my parents being involved in the process.
hiya, currently on sublingual E, but my levels aren't exactly great. injections are unfortunately not an option, but i've heard in the past that gels weren't ideal either. would luv some input on this :)
Hi everyone,
I am a 25 year old trans woman who has been on HRT for almost 3 years.
I switched to estrogen monotherapy via IM Estradiol Valerate injections in mid-January 2026 (targeting 200pg/ml E at trough) and have had very strange lab results ever since. I'm hoping someone has seen something similar and may be able to shed some light on what is happening because both I and my provider are absolutely puzzled.
Since starting HRT, I had been on 4mg oral estradiol split dose (2mg in morning, 2mg in evening) and 100mg Spironolactone daily. My final labs on this method were 219pg/ml E2 and 25.5ng/dl T.
Upon switching to injections, I started at a dose of 5mg every 5 days of Estradiol Valerate injected intramuscularly. I had labs taken two and a half months later at the end of March at trough on the 5th day about 4 hours before my next injection. My labs came back at 764pg/ml E2 and 45ng/dl T.
This was an oddly high E2 result for trough on the EV dose I was taking, so my provider recommended lowering my dosage to 4mg every 5 days and re-testing after 4-5 more injections at that dose.
I switched to 4mg every 5 days of Estrdiol Valerate injected intramuscularly and had my labs re-tested at the beginning of May at trough on the 5th day about 4 hours before my next injection. Despite lowering my dose however, my labs came back even higher for E2 and T at 782pg/ml E2 and 78ng/dl T.
Does anyone have any idea why both my already high E2 and my previously in-range T would have increased after lowering my Estradiol Valerate dose???
According to my provider, the lab results were in pg/ml for E2 and not p/mol and the test ordered was the same CPT code 82670 Estradiol as the final lab work before I switched to injections.
I am worried about lowering my dose further to 3mg or less every 5 days as the previous decrease from 5mg to 4mg already led to my T rising out of the 4-50ng/dl range.
We're arranging bloodwork using a different lab as a sanity check but it will probably be at least 2 weeks until I get those results since my next trough falls on Memorial Day... I will update this post with those results when I have them.
TLDR: EV dose 5mg/5days 762pg/ml E2 and 45ng/dl T -> EV dose 4mg/5 days 782pg/ml E2 and 78ng/dl T = ?????
All questions and hypotheses welcome.
I’ve noticed lately that depression has hit me hard. I feel most of my life I’ve been pretty solid in that department. Sure I’ve dealt with anxiety but not depression like this!. It feels crushing at times. Just want to crawl in a dark hole and be left alone. Emotional overload maybe?? I feel like a ball of sensitive nerves. All the feelings welling up. Things make me cry very easily. I’m sure others have dealt with these issues. What helped you overcome this?
I'm worried the 1/2 inch needle at 90° I've been using is too long for proper subq being lean, but maybe I'm just paranoid.
hi there, i started medically transitioning about 5 weeks ago and i’m concerned that i may have gotten prescribed too low of a dose of estradiol. i wanted to come on here to ask if anyone else has experience with this, because i’ve asked my doctor(s) about it and haven’t gotten any direct answers.
i was started on 100mg spiro and a .025mg patch by my first doctor, which seemed exceptionally conservative estradiol-wise, but i was just happy to start so i went along with it and started immediately. i felt almost nothing at first obviously but after a few days started to get mood dips into depression/irritability daily. i knew this was to be expected so i kept taking the same dose, but after about 3 weeks the dips were so frequent and strong that it was becoming concerning. i messaged my doctor about it, but she must have left the company or something because i was reached out to by a different doctor to schedule an intake appointment.
the second doctor asked me to get another blood lab done once completing 4 weeks of the patches/spiro combo, and that’s what i did (6 days ago as of my writing this). my estradiol level went DOWN from 37pg/mL pre-HRT to 28pg/mL and my testosterone levels have yet to come back, but i was kind of frustrated and it felt very dysphoric to see that my estradiol dropped after a month. i know it’s a long process but i don’t think it’s healthy for my estradiol to be THAT low still. and it’s clearly having an adverse effect on me.
so now i’m on 5mg of estradiol valerate via IM injection every 2 weeks, but i’ll be honest and say that still doesn’t feel like enough to me. or at least the every 2 weeks part doesnt sound ideal since the half-life is apparently ~5 days. i did my first injection 4 days ago and i’m still dipping into a bad depression daily, so i’m just wondering if that’s normal or if most people see an immediate difference when switching to injections. and yes i know that hormones can do crazy things and i will probably end up waiting a few weeks to truly see if my dosage needs tweaking, but i just wanted to gauge responses from others who may have had a similar experience. thanks!
When take E and get a monthly time of month or this doesn’t happen would be may question or I do get some form of having? As per op or post op?
I am a yet to transition trans woman and I hope to begin hrt while still under my parents insurance and as my mom didn’t kick me out when I told her I thought I could ask her to help me with hrt payments (not the whole thing but some). We have pretty good insurance but she said there is no way because it would be hundreds of thousands of dollars and know that’s wrong because I have been in trans spaces for a few months now. I am not demanding money from her or anything but I wanna know that it’s not 100k just to be sure. Any ways for any comfortable to share, about how much do yall pay monthly for hrt supplements and how much have you payed total?
my results from about a year ago had e at 888 pmol/l and t at 0.7 nmol/l. so i lowered my dosage (enanthate monotherapy) from 8mg to ~6.5 bc e is slightly high. despite having the lower dosage for a year, e has somehow risen to 1329 pmol/l and t has risen to 0.8 nmol/l. does anyone know how/why this can happen? prolactin has also basically halved for some reason
I’ve been on hrt for 4.5 years yet haven’t seen the results that you’d expect. Check my account if you want to see for yourself. Genetics and lack of a chaloric surplus aren’t the issue.
December 2021-May 2022: 2 mg estradiol sublingually daily and 25 mg of bica every two days
May 2022-June 2023: 6 mg EV subcutaneously every week, 25 mg of bica and 100 mg of P3 orally every day
May 2023 test results: Estradiol 577 pg/mL, testosterone 7 ng/dL
June 2023-August 2025: 4 mg EV subcutaneously every week, 25 mg of bica every day
July 2023 test results: Estradiol 386 pg/mL, testosterone 25 ng/dL, free estrodiol 1.2%, SHBG 94.7 nmol/L
Feb 2024 test results: Estradiol 251 pg/mL, testosterone 27 ng/dL
August 2025 test results: Estradiol 276 pg/mL, testosterone 19 ng/dL
August 2025-November 2025: 6 mg EV subcutaneously every week, 100 mg of P3 orally daily
November 2025 test results: Estradiol 567 pg/mL, testosterone 32 ng/dL
November 2025-February 2026: 4 mg EV subcutaneously every week, 25 mg of bica and 100 mg of P3 every day
February 2026-present: 4 mg of estrodiol sublingually every morning and 2 mg of estrodiol every night, 25 mg of bica and 100 mg of P3 orally daily
March 2026 test results: Estradiol 237 pg/mL, testosterone 33 ng/dL, free estrodiol 1.1%, SHBG 122 nmol/L
This week I started take methylated vitamin b supplements to see if they would make a difference. Nothing so far.
Question:
I'm thinking of switching from oral to injectable E. Simple question: is this a kit or are E syringes and needles provided separately?
Hey everybody!
I started sublingual e august 28 of last year, and moved to IM injections x2/week january 13 this year (almost 9 months in total).
I knew about the whole "use it or lose it" importance, and so I've been masturbating (until completion) once a week since I started. I know it should be more than that, but due to a drop in horniness (slightly has come back since my e got to a good level) and whatnot I've only been doing it once. When I do, although it feels a lot better in general, it is very difficult to get a full erection and I've realistically probably lost some size although it is difficult to tell.
I would really like to use it a bit more to prevent further issues, as well as I would really like to get out there and have sex again which I haven't done since I started. I've looked into what can help ed when on hrt, and it seems the easiest option is some sort of ed medication.
Has anybody done this before? What medication is best? Does it need to be prescribed? How often do I use it? How much does it help?
Would really appreciate it 😄
Hi all!! ☀️
I wouldn’t mind a little help with understanding if HRT is working on me like I want.
I had been applying Estreva gel (about 4 to 6 doses a day) for about 14 days, during which I noticed a clear reduction in spontaneous erections, breast bud sensitivity (with some full feeling) better skin too (so almost all awaited effects).
I then made the choice to switch to injections.
Seven days ago in the morning I injected 8mg of Estradiol Enanthate (EEn) from Astrovials in my thigh. I used a 27G 1ml 7mm long needle so I’m doubtful it was actually intra-muscular, it was more likely subcutaneous.
My thigh started to feel sore after about 24 hours, and went on being sore until 72 hours. During that time, I slowly decreased the number of Estreva doses I was taking (to compensate for the injection).
Today and since yesterday (the day after which I fully stopped Estreva) I noticed a noticeable decrease in breast bud sensitivity and breast fullness, as well as the return of spontaneous erections and a sort of surge in libido.
It feels to me like the injection didn’t work properly?
Following my current regimen I did a 4mg injection this morning with the same type of needle, in my abdomen and making sure this time it was subcutaenous with the proper technique since I don’t have longer needles.
So as a summary I took…
- Day 1-14 : 4 to 6 doses of Estreva
- Day 14 : 8mg EEn subcutaneous
- Day 15-20 : gradually 4 to 1 dose of Estreva
- Day 21 : 4mg EEn subcutaneous
Is it possible or likely that EEn doesn’t work well with my body? I don’t understand why I lost the feelings I felt after switching to injections, as I thought they would provide higher and stabler levels?
I’ve been doing EV injection monotherapy for over a year now and my levels have been fine, however, my last blood test (and the repeat one because my levels were weird) both had levels of T that are absolutely not suppressed. I’ve been on the same weekly dose for over a year and I’m suddenly having issues.
My E in both cases was over 260+ pg/ml, but my T was at 280+ nl/dl.
Has anyone else encountered this? Waiting to hear back from my doctor, but yeah
Can anybody help me 😭
hi all,
im not quite sure where else to post this.. I am transfem not fully convinced im desiring to transition into a woman but know I want feminizing effects of HRT. I’ve been taking 2mg of estradiol and spiro for 2.5 weeks now and I had already noticed a minor dip in my libido. I also just experienced my first orgasm in a few days and it was entirely pleasureless compared to my previous orgasms which were crazy and ultra pleasurable, especially after a few days.
i essentially started HRT as an experiment for myself after a long period of questioning..
apart from tha change, I haven’t noticed anything else but I’m not sure I like this feeling.. and I think I’m gonna stop after today.
what are the chances that my libido and orgasm return to normal after this period?
did any of you have a similar effect?
Preface: I will be making a doctors appointment about this, but just wanted to see if anyone else has experienced this.
Essentially, I switched from 5mg of oral estrogen (not taken sublingually ; I hated how it felt) and 100mg of spiro to 5mg of estradiol valerate injectable. I was on oral for 1 1/2 yrs before switching.
~3-4 weeks after starting injections i started feeling nauseous every time I eat, and need a solid 15 minutes minimum to sit and digest. I’ve also vomited roughly once week starting around the same time.
I feel like it’s possible it’s the estrogen but it’s the same medication essentially so I’m a little confused, and wondering if it might be due to some other things (moving, change in diet, end of school year).
Any personal anecdotes or advice help :)
I have been on HRT for about 2 years now taking 200mg of spiro and 2 mg of E a day with that I was still getting erections. Not random ones but still getting them. A friend suggest going to 4 mg of E and been doing that for almost 2 months now but I am still getting them. What else can I do other than surgery to stop getting them. I really need to shrink.
I haven’t been shooting any cum for a good year now and just dribble when I orgasm so I know my T levels are low but not sure what else to do.