r/CRPS

For me, it's a broken bladder. The day I finally went to a doctor in late 2019, I'd peed over sixty times. Had to go to the ER for quick meds until I saw a urologist alongside by neurologist. I now have two implants, spinal cord & interstim. Three meds for pain and two meds for bladder, most of which I started this year. For the first time in a long time, I feel human.

I truly hope you all get there too.

Me tuvieron que suspender la medicación por una enfermedad. Durante el tiempo sin medicación, el dolor aumentó mucho. Al volver a tomar la medicación, el dolor continua muy alto y no hay manera se bajarlo ni subiendo aún más la medicación.

Esto es un infierno.

Short story:

• Sodium channel NaV1.7 is a powerful protein to control pain, as demonstrated by humans who can't feel any pain
• Blocking NaV1.7 in the sympathetic nervous system leads to side effects
• Targeting NaV1.7 selectively is very hard, sodium channels look alike
• Encoded has developed a treatment which knocks-down the gene coding for NaV1.7 in pain sensing neurons only, using viral delivery of miRNA

There are ever new ways to target proteins central to pain control, which can deliver both strong analgesia and fewer central side effects. The cool story here is just their technology and that we are seeing ever more ways of achieving it. The fact that private money is funding it is really good news. Even when these companies fail, the fact that the money is there to do the research means we are heading into new territory where a successful new pain therapy isn't decades away anymore.