u/--Vercingetorix--

Calorie restriction is one of the most consistently replicated findings in aging research. Cut food intake by 25 to 30 percent and almost every organism studied lives longer and ages more slowly: worms, flies, mice, and in the most rigorous human trial ever conducted, people. The problem is obvious. Almost nobody can sustain a 25 percent reduction in calorie intake indefinitely. The intervention works. Almost no one can do it.

The central mystery has always been the mechanism. What specifically does eating less do to the body that slows the biological aging process? If scientists could identify the precise pathway, they could potentially target it pharmacologically and replicate the benefit without the hunger.

A team at Yale School of Medicine led by Vishwa Deep Dixit just published what may be the most specific answer yet to that question. The study, published in Nature Aging, drew on data from the CALERIE trial, the most rigorous human calorie restriction study ever conducted, in which 220 healthy adults cut their calorie intake by 25 percent for two years.

When the researchers analyzed what changed in the blood of calorie-restricted participants, one protein stood out above everything else: complement component 3, known as C3. It dropped significantly in the calorie-restricted group and barely moved in controls. C3 is a central node of the innate immune system, involved in tagging pathogens and damaged cells for destruction. But it is also increasingly implicated in driving the chronic low-grade inflammation that accumulates with age, a process called inflammaging, which underlies virtually every major age-related disease.

When the researchers blocked C3 in aged mice without changing their diet, their inflammation profiles looked like those of calorie-restricted mice. Their metabolic health improved. Their thymic function, a measure of immune system vitality that typically collapses with age, was preserved.

The hunger, it appears, may not be the point.

Moin.

Heute kam mein Bescheid für 2024 und ich musste feststellen, dass das Finanzamt meinen eigentlich zu verteuernden Gewinn einfach als landwirtschaftliche Einnahmen zusätzlich(!!!) zu meinen sonstigen Einnahmen verrechnet hat.

Also 23K Mieteinnahmen - 10K Ausgaben = 13K zu versteuernde Einnahmen.

Daraus machte das FA 23K Mieteinnahmen + 13K Landwirtschaft = 36 K zu versteuern, anstatt 13 K zu versteuern.

Ich bin seit Ende 2023 chronisch krank und musste meinen landwirtschaftlichen Kleinbetrieb dicht machen. Einnahmen gleich null. Ohne die Mieteinnahmen wäre ich geliefert, da ich nicht mal das Haus verlassen kann etc.

Wir wollen morgen dort anrufen und fragen, was das soll. Was würdet ihr machen? Gibt es etwas das ich wissen sollte? Ich habe wenig wissen über solche Angelegenheiten und bin in einem furchtbaren gesundheitlichen Zustand. Kann mich kaum mit etwas befassen und konzentrieren. Die Erklärung habe ich, wie die letzten Jahre auch, mit Elster gemacht, da es bei mir ja recht simpel ist und auch sonst immer geklappt hat.

Danke

Just found out that the creator of the mold science sub was banned and that his posts have been removed. He had some good ones with links to scientific studies. Does anybody know what happened and does anyone have the collection of the links to the studies?

https://www.reddit.com/r/MoldScience/comments/1mc0meo/symptoms_of_mold_illness_may_be_a_root_cause_of/