Tested Manticore: Tactical Combat with a vanilla save
Just to let you know, this is from the author who created 'skeleton key' - a great qol mod, and popular fuel balance mods. So I had pretty high expectation.
There was only one option to tweak, something about the health scaling, and the default was 'tactical'. I really wanted to try 'death wish' but it crashed my game immidiately with weird heartbeating sounds and camera spinning out of control. Since the change makes an auto-save, it indefinitely loaded the same new save and crashed again. So I sticked to the default 'tactical'.
One of the things I noticed was the skill tree changes. They are mostly in the combat tree. My character is very high level (over 200), so I didn't have to consider which one to level up. They all seemed like some balance changes. Low level players might feel the changes in bonuses more, but not me.
The other thing I noticed was my weapon damage. With all perks and bonuses, it was over 10,000 before (I'm a sniper using the resonator rifle). Now it was around 1,000. Nevertheless, the enemies seemed to die with one-hit (health scaling?). I think this mod probably have more impact for low level players, but not for me. With the damage numbers hidden, I couldn't tell much differences.