TRT yes or no / 42M, chronic fatigue. Need help making sense of my bloodwork and finding a solution.
42M, 173cm/73kg/natty BG around 15%. Lifting consistently for 3 years, 4-5x/week, strength and hypertrophy focus. Diet is clean, high protein, whole foods. Sleep is 7h/night. I smoke cigarettes and weed daily. General health checks done and all clear: colonoscopy came back clean, full cardiac workup done as well, heart is fine. On Monday I have an appointment with an andrologist who will do an ultrasound of my balls to rule out anything structural on that end.
Main symptoms: persistent baseline fatigue that doesn't go away regardless of rest and regardless of where my testosterone levels are at, low motivation, flat mood. The symptoms have increased since I started training.
Supplements: creatine, whey, multivitamin, iron, D3+K2, boron, zinc, magnesium, ashwagandha, maca, L-theanine, omega-3.
Here’s my bloodwork. All tests were done fasted in the morning.
Dec 2025
Testosterone total: 987 ng/dl ✓
IGF-1: 191 ng/ml ✓
Vitamin D: 74 ng/ml (slightly above range, ref: 20-70)
Ferritin: 72 ng/ml ✓
TSH: 0.62 ✓ | fT3: 2.94 ✓ | fT4: 1.70 ✓
CRP: 1.90 mg/L ⚠️ (ref: <1.0)
IgE: 169 kU/l ⚠️ (ref: <100)
April 2026
Testosterone total: 329 ng/dl ⚠️ dropped ~660 points in 5 months
Testosterone free: 7.6 pg/ml ✓ (ref: 5-21)
IGF-1: 227 ng/ml ✓
Ferritin: 74 ng/ml ✓
Cholesterol: 223 | LDL: 146 | HDL: 54 | Triglycerides: 148 ✓
HbA1c: 5.4% ✓
TSH: 0.78 ✓ | fT3: 3.09 ✓ | fT4: 1.50 ✓
CRP: 2.91 mg/L ⚠️ (ref: <1.0)
IgE: 146 kU/l ⚠️ (ref: <100)
Liver / Kidney / PSA: all clear ✓
May 2026
Testosterone free: 11.0 pg/ml ✓
LH: 3.3 mIU/ml ✓
FSH: 4.0 mIU/ml ✓
Estradiol: 19 pg/ml ✓
SHBG: 31.4 nmol/l ✓
Prolactin: 3.7 ng/ml ✓
Cortisol: 102 ng/ml ✓
Ferritin: 75 ng/ml ✓
B12: 1050 pg/ml ✓
HbA1c: 5.3% ✓
July 2026
Testosterone total: 535 ng/dl ✓
Testosterone free: 14.3 pg/ml ✓ (ref: 5-21)
LH: 4.8 mIU/ml ✓
FSH: 3.9 mIU/ml ✓
Estradiol: 18 pg/ml ✓
SHBG: 26.9 nmol/l ✓
Prolactin: 5.7 ng/ml ✓
Cortisol: 78.8 ng/ml lower third (ref: 20-200)
HbA1c: 5.3% ✓
TSH: 0.73 ✓ | fT3: 3.04 ✓ | fT4: 1.46 ✓
Vitamin D: 65 ng/ml ✓
B12: 955 pg/ml ✓
Zinc: 931 µg/l ✓
Ferritin: 71 ng/ml ✓
Cholesterol: 201 | Triglycerides: 58 ✓
Transferrin saturation: 13% ⚠️ (ref: 16-45%) below range
Iron: 44 µg/dl low end (ref: 40-160)
Liver / Kidney / PSA / HIV / Hep B+C: all clear ✓
The hormone panel in July looks fine on the surface. Total T 535, free T 14.3, LH 4.8, SHBG 26.9, all within range. HPG axis seems to be functioning.
What I can't explain is the T crash. 987 in December to 329 in April, a drop of ~660 ng/dl in 5 months with no obvious lifestyle change, then partial recovery to 535 by July. My energy was low the whole time regardless of where T was sitting.
A TRT clinic I consulted diagnosed this as functional hypogonadism, meaning symptoms despite technically normal total T, combined with relatively low free T values. They said I could start with TRT at 125mg/week. They noted that Enclomiphene could be an option but is not approved in my country and harder to source, and that in their experience most patients do better on TRT than on Enclomiphene treatments even at similar total T levels.
Other things that stand out:
CRP elevated in both Dec (1.90) and April (2.91), consistent low-grade inflammation. I smoke cigarettes and weed daily so that's likely part of it, but wondering if it plays a role in suppressing T.
IgE elevated in both Dec (169) and April (146), consistent across two panels. Planning a specific allergy panel to find out what's driving it. Transferrin saturation at 13% despite normal ferritin. Realized I've been taking iron every morning with coffee and milk which blocks absorption. Switching to fasted with vitamin C going forward.
I am mainly looking to increase my energy and build more muscle without compromising my health. If TRT could help me achieve that, I would be open to it. It would be great if someone could review my stuff and tell me whether TRT is the right solution for me or if you see other options