




Enclomiphene efficacy fall-off
Context: 24M, 150lbs, somewhere around 15-17% body fat by best visual estimate. Heavy training and strict diet, good sleep. Consistentlyly low 400s/high 300s total T, with FSH and LH both at 2 when not taking supplements. Enclomiphene was taken 12.5mg/EOD as a monotherapy. Yes I am young, I have had that argument a hundred times. Please just post thoughts related to the data. I have my personal reasons for going this route.
I have been taking enclomiphene for roughly 8 months now, and have apparently found the figurative end of the road. I know multiple people report this efficacy falloff around the six month mark, but wanted to add actual lab results and data for anyone tracking this or interested in the drug used as a monotherapy.
Six Month bloodwork is first, eighth month is second. I’ve also labeled each picture.
As you guys can see, it seems like everything stopped working. And my estrogen has shot through the roof-leading to some pretty bad acne breakouts, low libido, and just kind of overall feeling groggy and beat up.
I have not changed my lifting routine, diet restrictions, dosing, supply, or anything between these bloods. I am operating in a very mild caloric deficit (200), but that was in place during the six month bloods.
Would love to answer any questions, or have any discussion about this! I will not be taking the enclomiphene for a few months while my signaling resets and estrogen returns to baseline.
Edit: yes I absolutely expected this to happen. I do not believe it is worth it to continue the treatment with an AI when I could simply just stop taking the enclomiphene, and restart from zero later. I am aware it is not a PED, but it has helped my energy levels and mental state significantly.