Is an MCAS flare up marked by a hypersensitivity to like everything and increased pain sensitivity to everything?
I (33yo female) have been dealing with a sudden onset of issues since January 2026. It coincided with an androgen blocker I took for a while (1.5 years?) and stopped, as well as a couple rounds of antibiotics for dental issues.
TLDR- does MCAS cause heightened sensitivity to things that didn’t used to be painful?
Symptoms include:
- Sudden onset of migraines with visual aura primarily during ovulation (or the few days leading up)
- other headaches and light sensitivity
- an extreme intolerance to caffeine when I have been drinking a lot daily since puberty - I develop tachycardia and PVCs in response to only a little bit of caffeine , had to go to the ER multiple times before I figured it out
- very heightened pain sensitivity - I used to regularly get waxed and electrolysis but now they’re so painful I had to stop
- heightened reactions to all supplements and medications - Zofran gives me tachycardia now, magnesium theornate I have to take 1/3 the minimum dose and it works too well, progesterone cream I have paradoxical activating reactions to now when I tolerated it fine for years , etc
- my last few routine blood draws have been very painful, and I even got an injury from a standard IV ??? (Nothing visible on outside but whole arm hurt for 2 months afterward)
About 5 years ago I was treated by a naturopath for histamine and leaky gut issues but primarily manifested as stomach symptoms in response to certain foods. It completed fixed all my stomach symptoms and it was a miracle as I struggled with it for a decadeI and people always blamed it on my anxiety. BUT I NEVER had neurological or HR issues related to histamine before.
But a month ago my psychiatrist brought up MCAS as a possible unifying issue and i restarted taking Xyzal and started daily pepcid. It has cut down on headaches for sure.
This could all just be related to me having depleted allopreg levels caused by the stupid androgen blocker but this is all so new to me I wanted to get thoughts.