r/SemaglutideCompound

I’ve decided to stop taking sema. Every week I get a terrible case of GERD and end up throwing up. Has anyone else had this happen? How long did it take for it to go away? I was supposed to take my shot today but I didn’t and I hadn’t had an episode since last wednesday.

I'm staying with my mom about 45 min away from home and my meds were delivered today. It's in the 90s today (Tuesday) and tomorrow, then 60s. Will I need to stop by today or tomorrow to get it or will I be able to wait until Saturday?

They usually pack it with multiple ice packs in a cooler but I'm still worried.

Thanks!

I took my first injection Friday night. Saturday I didn’t feel much of anything besides some mild nausea and an inability to eat very much. Yay! But, the heartburn was horrible, and I was eating very bland things. This morning I woke up with a huge headache. I took a nice drink of water and then I belched twice. The first belch tasted like my afternoon eggs from the day before and the second time tasted like my soup from dinner. The headache has lasted all day. I went back to bed after drinking more water, but did not eat anything. I’ve finally had my first meal of the day and it is late afternoon. I’m not sure if the headache is a result of the meds or possibly caffeine withdrawal. Or maybe both. I usually drink Diet Coke throughout the day and I haven’t wanted it. And that’s probably a good thing given the heartburn. I guess I am looking for reassurance that these side effects decrease overtime? I really hope I don’t feel this way after every shot. I really want to drop the weight. But I also have to be able to function in my everyday life. And that means working 40 hours a week and being able to be present for others in my household. Any tips or encouragement would be greatly appreciated. I also felt like I had to drink so much water yesterday that there was no room to eat. I had to struggle to get the calories. And I did not hit my protein goal for the day. Not even close.

I started compound semaglutide in mid December, at 178 and am now 156. In the beginning I had no side effects, which was great, and I lost about a pound a week. For the last 4-6 weeks, I have not enjoyed myself. I went up a few doses, and am now experiencing hair loss, serious brain fog and fatigue, and depression. I feel so unlike myself. Getting in the shower and seeing my hair basically fall out made me cry. Eating fiber, protein, taking creatinine, D3, and I feel like shit. I haven’t even lost weight in the past feels weeks. I will consult my doctor, but I’m serious considering tapering off. Has anyone felt better after these side effects?

Hi all quick question for those who might have been through this. My previous provider did not have B12 in their formula only straight compounded Semaglutide. I have recently switched providers and will be starting a new bottle today that does include B12. It looks to be 2mg/ml. I typically took my shot around 8:30 at night. Will the B12 in this make any difference? Should I do a morning or mid afternoon dose now instead?

Spent several months reading about GLP-1 medications before starting and wanted to share what I found for people earlier in the research process.

The main options most people are comparing are semaglutide and tirzepatide. There are others but those two have the strongest evidence base and the most real-world data at this point.

Semaglutide (brand names Ozempic, Wegovy) works through the GLP-1 receptor. It reduces appetite, slows gastric emptying, and has effects on blood sugar regulation. The weight loss data from the STEP trials showed about 15% average body weight reduction over 68 weeks.

Tirzepatide (brand names Mounjaro, Zepbound) adds GIP receptor activation alongside GLP-1. The SURMOUNT trials showed 20-22% average body weight reduction. The dual mechanism also appears to reduce GI side effects for some people compared to single GLP-1 agonism.

Practical considerations: both require a prescription. Brand versions are expensive without insurance. Compounded versions through licensed pharmacies exist and are significantly more accessible cost-wise, though the FDA has been updating its position on compounded GLP-1s so it's worth checking current status if that route is relevant.

Side effects for both: primarily GI, mainly nausea especially in the titration phase. Both can cause muscle loss alongside fat loss, which is worth managing with adequate protein and resistance training.

Not a doctor, not giving medical advice. Just someone who did a lot of reading and wanted to organize it usefully.

I am very confused. I am a 36 year old female-- 5'7 and I started at 196lbs in September. I've hovered between 180 and 200 my whole adult life. I started sema in September and lost 30lbs by Christmas eating around 1400 calories per day. I've lost another 10 from January until May. I have 10-15 to my goal. I have upped my dose a few times over the last 5 months but I stayed stalled or very slow weight loss. I have struggled a lot more with both cravings and physical hunger the past few months. Here is the weird thing though-- when I have a few higher calorie days as long as the food is healthy--that is when I suddenly see some weight loss. I am very confused and having a hard time finding a plan that works for me because eating more feels counterintuitive so I keep reverting to 1400 calories and then I get super hungry and eat too much. The other hard part is big meals don't sit well because of the medication so all I want is to snack all day but that also doesn't feel like a super healthy habit. Is there a way to figure out your actual calorie needs besides just those generic calculators? I do not exercise. I have a 2 and 4 year old and am a full time teacher so I rarely sit down and we go for walks and stuff but no formal exercise. I'm just feeling a little discouraged. I feel really healthy and my clothes fit great and I am so happy but I was having so much success and now I feel so confused.

This is my third week on a compound. Took 3 doses. I am not feeling any difference whatsoever. Same hunger as before

Do i have to be on a higher dose or go for branded meds to see some changes?

My insurance not covering branded

I take it on my stomach. I do have a lot of fat around the belly area. Does that affect anyway? Will it help if i took it another place?

TIA for any comments

Hi all! I want to lose about 50lbs and have been working with a nutritionist since January. Down about 10 just by tracking food and moving more. I had been on the fence about glp1s but finally bit the bullet and got a prescription. My meds arrive tomorrow (Wednesday) and I have an event Thursday. Should I expect side effects by then? Wondering if I should delay. Starting at 0.2mg compounded semi.

Thanks in advance!

So I had great success on Wegovy list 45 pounds then had to stop from having multiple surgeries. When I was able to start back insurance no longer covered so I went compound and zero weight loss. So I then switched to Tirzepatide and still zero weight loss!! I have been on compound 7-8 months and it just doesn’t work for me. I am considering going lily direct so I can get name brand Zepbound. I am thinking maybe my body just responds better to name brand since I did well lost weight on Wegovy and zero weightloss on compound this stuff is too expensive to have no results!! Anyone else have this experience and then go back to name brand then start to lose again? My doctor obviously prefers name brand and says she thinks I will have better results. But who knows..

Hi! Started the melt under the tongue pills just had my first dose increase, and it is working-the food noise is gone, feeling fuller. However, I still struggle after work, about 4 pm. In currently take it when i first wake up, at 6 am.
Can I take it later! My worry is hay you are supposed to not drink or eat before you take it. So if I wait until 9:00 let’s say, that means no water or anything until then, correct?
Does anyone have experience with this?
TOA

I started compound sema on march 3rd. I’ve lost about 6 lbs. I started on 12.5 units and now I’m at 25 units. I’m 4’11” and currently am fluctuating between 135-136 lbs. I’m eating around 1200 calories a day and even that is a struggle sometimes. I’m just frustrated because I thought I would have lost more by now. I’m hesitant to go up to the next dose because of side effects (I basically have no appetite on this current dose so I can’t imagine how I would feel moving up another dose). Any advice? Encouragement? I’ve been trying to lose this damn 30 lbs for 10 years now and nothing is working.

So I'm due to take my 5th compounded semaglutide shot this upcoming Wednesday and am supposed to be increasing from 0.25mg to 0.5mg, but I'm down 13 lbs, don't have any food noise, and am still dealing with nausea and food aversion on the current dose.

For those of you that have gone through this, what do you recommend? What worked for you? Do I go slow and steady and stay here until I plateau or do I bite the bullet and go ahead and up the dose?

And before anyone tells me to check with my provider, I've already messaged them on the portal and waiting for a response. Just wanted to hear from others who have been there!

I took sema years ago and lost weight. I stopped because I couldn't afford it anymore after I took a break from work when I lost my brother. Now two years later I am hearing great things about tirzepatide and I decided to start back on a GLP-1 and chose tirz. I started tirz in October of 2025, so I have been taking it for about 7 months.

With diet and exercise I have lost a total of 11 pounds. Sure, there's probably some factors involved in that low weight loss but the whole time I'm remembering losing 20 pounds on the sema for the 2 months I took it 2 years ago.

So here's the interesting part. My provider sent me my GLP-1 refill 2 months ago. I was taking it and some weeks later I realized my vials said semaglutide and not tirzepatide. I lost 5 pounds in those two weeks. I called my provider, they apologized and made the order right, they overnights me tirz vials and my weight loss is now back to a halt. So, guess what I'm gonna do...I'm going right back to semaglutide. For me, it has given me the best results. I know it isn't the preferred med for everyone, and also know some have described really bad side effects. But I wanted to share my honest experience thus far and frankly speaking I am glad the provider made the error.

Hey all! I am 4'11" and I'm looking to just lose a few stubborn pounds before my wedding. Mostly belly fat.

I have a very active lifestyle, working out 4-5x a week, I eat pretty healthy. My short frame just keeps weight on. I'd love to lose 5-8 pounds before September.

Obviously my BMI is normal for my height so Willow is looking like it's my best option as a doctor definitely won't prescribe to me. What is everyone's experience on this? Anyone have any advice?