r/bioinformaticsindia

▲ 3 r/bioinformaticsindia+1 crossposts

Looking for a bioinformatics internship

Hi everyone!!!

I am msc bioinformatics 2nd year student and is looking for genuine remote internship in bioinformatics in ngs analyst. I will love to work with startups.

I am comfortable with linux, r , Python, sql and has built transcriptomics , wgs project on github.

Any senior who can guide what more I can learn to get a job will be great help.

Any type of guidance and help will be grateful.

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u/Similar-Peak-5716 — 4 days ago

MSc Biochemistry to Bioinformatics: M.Tech, another MSc, job hunting, or PhD? (India)

I’m currently pursuing an MSc in Biochemistry in India and would appreciate advice on the best route into bioinformatics/computational biology.
I’m considering:

  1. GATE 2027 → M.Tech in Computational Biology/Bioinformatics
  2. Another MSc in Bioinformatics
  3. Short courses and projects → job hunting
  4. PhD in Bioinformatics/Computational Biology, possibly later

I am not sure if i want to go for a PhD right now because i want to start earning money sooner, but i am open to considering one in the future.

Which route offers the best prospects in terms of employability, career growth, and return on investment in India?

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u/Awkward_Thanks5784 — 6 days ago
▲ 22 r/bioinformaticsindia+1 crossposts

Can I integrate a spatial transcriptomics dataset with a bulk RNA-seq dataset for any analysis of tumors?

Hi everyone,

I am working on a cancer RNA-seq analysis project, and I have found two GEO datasets that I would like to use together. I am trying to understand whether there is a scientifically valid way to integrate them rather than simply analyzing them independently.

Dataset 1:

Xenium-based high-throughput RNA in situ hybridization/spatial transcriptomics

Contains normal tumor samples, DCIS, and invasive breast cancer samples

Dataset 2:

Bulk RNA-seq

Samples are classified according to metastasis status and breast cancer molecular subtypes

My original goal is to perform a normal/control vs tumor/disease-type analysis and identify differentially expressed genes and biologically relevant pathways, followed by downstream analysis.

However, the two datasets are clearly different in terms of technology and experimental design. One is spatial transcriptomics and the other is bulk RNA-seq. So, is it scientifically/statistically valid to integrate these two datasets in a single study?

I am particularly interested in knowing what would be considered a methodologically defensible approach for this, rather than simply combining the two matrices because they contain overlapping genes.

Any suggestions regarding an appropriate integration strategy, statistical design, or published examples of similar spatial + bulk RNA-seq analyses would be very helpful.

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u/harshitnaman — 13 days ago

Career in Bioinformatics

Ok high schooler here.... I am very good at bio 98%

, good at computers that they teach in school which is a libre office related things....99% hehe, (Does anyone even care about libre office writers nowadays??) So i started learning python on my own... I guess,Once u understand it, It's mainly practice but BUT i am weak in maths... So I guess I will opt for pcb+applied maths and cs as electives... My family is full of doctors and engineers and saying I should become like them😀... If I study very hard... Can I do btech and mtech if required... I want to spend time on masters by my choice plus my brother is being killed for he didn't do masters in web development so anyways... Is bioinformatics even good tho??like moneywise in India (my father says they get low salary and education in india is messed up due to no research facilities and corporate greed and wars, also very tight market and more stuff )... I am not into academia... I just want to be free, fast and furious and earn money...money is not a problem... Can afford but they want me to get in by my strength so very restricted spendings which is a good thing...

My question basiically

Are opportunities and markets good??

Corruption here too??

Like how much will u get? (Optional question, heard it was very dependent on experience)

Pcb+applied maths(as a weak math student, I will push through) +cs then btech then mtech(let's dream big and say I do btech at iiser and mtech at iisc or abroad(good idea?)

India?? How is everything bioinformatics related here??... I heard many are unemployed or old men in high positions??

What other uni will yall recommend??

Just tell what u all did along with a pinch of advice ... That's even better ... As well as old men at high positions and unemployed people are too welcomed to say everything u kept in ur heart 🥳🥳

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u/Alternative-Top-4864 — 12 days ago

Cuet pg

So basically I'm in 1st year of bsc(hons)biotechnology and wanted to prepare for iit jam, cuet pg ,gat to get best institute or college for my post graduation, to get better learning for my research career further. So is there any channel or batch that I can join as a 1st year student for my preparation. Or just have to wait for the final year and then do preparation. I'm so clueless rn, about the syllabus and how to prepare. Help mee...

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u/rishi2977 — 12 days ago