r/caplyta

Hello Friends, I am a 61 year old woman with a long history of MDD, OCD, and GAD from a traumatic childhood that included sexual abuse.

Most of my life have been on SSRI's - since my 20's, and those have gotten me by, but lately the constant anxiety, dread, and underlying depression are getting to me. I am having trouble sleeping, and taking 50 mg Trazodone for that, but it's not helping. If I take any more, it affects my memory. I am also on 20 mg of Lexapro, which is helping with motivation and energy. However, I feel anxiety and depression every moment.

I have already been on Paxil, Prozac, Trintellix, Viibryd, Zoloft, and short trials of Latuda and Abilify as augmentation. Paxil, Prozac, and Zoloft each worked for years, but then pooped out. Trintellix and Viibryd greatly increased my insomnia and anxiety. Ability worked for a while, like 2 months, and then pooped out. I also spent a lot of money I should not have in those 2 months. Latuda helped until I had a breast lump, and the breast doctor said I had to go off it because it increases Prolactin, a risk for breast cancer.

My question is has Caplyta helped you with any of the above diagnoses? And has anyone been able to stay at 10.5 of 21 mg longterm? I hate high doses of medications.

Any advice or support would be greatly appreciated. Sometimes I wonder who I would be if I had a normal childhood, but I know there is no point in thinking that way. Meds, sigh.

I have severe gut issues

15 times diarrhea/day

Can this be a cause of severe sleep disturbances?

Caused by lumateperone 42mg

I want to withdraw from this medicine

But when I tried to skip a dese developed severe jittery feelings + akathesia gpt worse for a day

So since I was uber hyper last Thursday after 4 days of hell, my mood has settled into a calm, but energy filled bliss.

I can sleep better and stopped taking OTC sleeping pills.

I wake up faster and more refreshed whether it’s 6 hours or 8.

I’ve been eating better and I’m a lot happier!

I know I need to wait til the 6 week or even 8 week mark for a more valuable assessment but the side effects have subsided and this mood has been consistent.

Took the 42mg pill with a glass of water and found myself on this page instead of going right to sleep! For the most part, I feel encouraged by a lot of what people are sharing. I am, however, mostly nervous about the side effects with sleep. I am so tired all of the time with seroquel and hoping this will move me into a different and more productive direction. Would love to hear about folks' experience with sleep and if you recommend taking it at night or morning?

Hi everyone,

I have some form of bipolar, have been on lamictal for like...11 years now. I was pretty stable for a long time, but this last year and change has been ROUGH. A lot of ups and downs (mostly ups) that left me with very little "baseline" moments.

I'm on 200mg lamictal and when I started my "ups" last year I was put on 25mg quetiapine, plus prazosin 'cause my sleep has been trash (sleeping but sleep has never been restful). Over the last year I've had to increase to 100mg to get relief.

When I had my last meet-up with my prescriber, they suggested adding caplyta and reducing the quetiapine to "as needed". Reading the posts here make it sound like caplyta has made positive improvements for y'all, but it looks like it's for BP depression and not mania?

Do any of y'all have an experience with a med mix like this, or adding caplyta for stability specifically when the issue seems to be hypomania/mania?

Much appreciated for any info. I have a meeting with my prescriber next week so will address these concerns directly, too.

Thanks

I just started 10.5 today (I forgot my doctor said take it at night and i accidentally took it in the morning) and ive been having flu like symptoms all day, it started a few hours after taking it. Ive been freezing and having chills all day and feel pretty woozy and fatigued. is this pretty standard for side effects and how long do these symptoms take to go away?

I’ve on week 3 of caplyta on 21mg for the last two and the entire time I’ve felt like my insides are buzzing, similar to adrenaline, ALL the time. It gets my heart rate up and I’m overall so much more anxious because of this buzzy/adrenaline feeling. Has anyone else experienced this? Did it go away?

How to weane off of lumateperone 42mg safely

As when i skipped a dose got severe akathesia/restlessness for 24 hours

I started Caplyta two weeks ago at 10.5 mg. I have been dealing with the worsening depression episodes of crying and somnolence as in 12 hrs a night. Has everyone had an experience where they got worse before they got better? Some of the other antipsychotics give me bad akathisia and am borderline with my cholesterol and am overweight so I don’t have many options. I’ve tried vraylar, abilify and zyprexa. I just want to know if I should tough out this intense depression or try something different?

I’m curious how others have tapered off of other antipsychotics while adding this drug to their regimen.

I’ve been on the 3.?mg dose of Vraylar for BP2 for about three years now. My doctor said I could just take both the Vraylar dose + the 42mg Caplyta dose simultaneously for a week, then drop the Vraylar off completely after that first week. The pharmacist told me that that was a really weird recommendation and said I could just stop taking the Vraylar because the half-life is so long.

How have you managed this before (whether Vraylar or a different drug)? Not asking for medical advice, just anecdotes — Going to reach out to my doctor regardless but curious what I could suggest as far as what has worked for others.

I read side effects mainly dissipate after 6 weeks, but only for 50% of people.

I'm on week 7 of 42mg, and the fatigue and brain fog has only gotten worse.

My waking life feels like how you would feel after being awake 48 hours. That numbing blunt feeling in the front of the brain and behind the eyes.

Sad to feel like I cannot healthily take advantage of the depression reduction this drug has a reputation for.

But coming back to hopelessness because of the physical fatigue is by far a great opposite of the intention.

currently prescribed 10.5mg + 300mg lithium. i was previously on 21mg alone and requested to decrease my dosage due to hypomania and a rash. the rash went away for about a week and a half after my decrease, but now it’s returned. i talked to my psychiatrist about it, as well as other issues i’m having— mood swings from my new iud, etc. he didn’t really have a suggestion for the rash, aside maybe switching from caplyta to seroquel.

otherwise, i love being on caplyta. i have nothing but great things to say about it, aside from this damn rash. has anyone else experienced this? does it go away eventually?

update: i called my nurse and she (obviously) instructed me to stop taking it until i see my psychiatrist again, which is next week.

hi everyone i’m looking for some answers! I have Bipolar 2 disorder, and I’ve been on pristiq 100mg and seroquel 75mg for some time now. I’ve started on Caplyta on 7-9-26, and my psychiatrist started me on 42mg. The first week or two was great, and I had little to no side effects. But now the last 3-4 weeks I have had extreme food aversion. I get the hungry sensation but as soon as I go to eat I physically cannot make myself. It’s like my stomach is just rejecting food. Im lucky if I can force down 1 meal a day, and when I can eat it’s just the few same things that sound appetizing. Has anyone else experienced this? Does it go away?

I’ve been on 21mg for about 5 weeks, I’ve had some minor improvements and no bad side effects. however, for the past 3ish weeks, I’ve had random singular palpitations maybe three-four times a night when it gets close to the time to take my dose again.

it feels like an electrical pulse throughout my whole body, I even feel it in my teeth?? Has anyone experienced this? I don’t think it’s harmful but it’s certainly weird…

Hey guys. Hope you’re all doing well! So did anyone else start this medication thinking it’s the most effective move ever taken for depression, only for it to gradually dwindle to nothing after 10 months? I’m at 42 mg so it’s now gonna be a process of tapering when I’m ready. I’ve lost hope in psych meds. I started Prozac recently. Got a good 2 months of feeling great out of it. Now that crapped out too. I’ve never felt so depressed. Don’t let my post dissuade you from trying Caplyta or staying on it. But I can’t be the only one this has happened to. It works just long enough to keep you on it while physical dependence develops and then once it quits working..surprise! Now you have to taper off and feel worse! It’s causing me to lose so much hope. They all do this, it’s not just Caplyta. Jw if anyone else experienced a huge relief at first, only to end up devastated.

Did anybody not start at the higher doses? My psych is starting me on 10.5mg (I'm also on haldol 5mg) for schizoaffective. The side effects I read on here are a bit disheartening, but it seems to be on the 21mg or 42mg. So has anyone started at the 10.5mg? How was it for you? Manageable?

My son has been on caplyta for about 9 months now and it is starting to cause him to wake up at 3am for the past 4 nights and he cannot go back to sleep. He has been pacing all day and now today he keeps flicking his wrist and making these sounds almost like random grunts. What is going on???? He has an appointment on Monday with his psychiatric nurse so I definitely want him off of this but for now is there anything that would help?

Hi all. My post is basically what the title says. I used to take Caplyta every night at 10pm, but I’ve always had this weird side effect where I almost pass out from time to time when it’s almost time to take my Caplyta again. I’ve been taking it in the morning for three days now and my insomnia has been terrible. I’m not able to sleep until 4-5 in the morning, and I never sleep well. I usually wake up every 30 minutes at least, and probably only sleep 4 hours a night.

Is this normal? Will the insomnia go away? I’m thinking about telling my psych I’m switching back to taking it at night. Being dizzy is better than not being able to sleep!!

I just started taking 10.5 mg of caplyta and I would search individually for these questions but the room is spinning so I apologize in advance

A little about me: weapons grade OCD, bipolar one (in a major depression), severe anxiety

I take lithium, sertraline, and Klonopin. I have previously tried, Abilify, risperidone, and Latuda.

Doctor starting me on a very low dose, but I'm already feeling very dizzy. I'm also not remotely tired and actually feel like I might be a little bit hypomanic or just very, very anxious. Also, my nose is stuffed up more than usual, but I'm not too concerned about that… Just curious if it's happened to anyone else.

I am mainly concerned about the inability to sleep. I also snapped at a lady at the laundromat today, which is something I usually don't do. Can anyone give me guidance as to whether the side effects will go away and whether you've experienced similar? I really thought this was going to help me sleep. Thank you.