Guide to what factors that influence VO2 max (research based)
I understand there's many different opinions on the importance of an individual's absolute VO2 max number. Personally how VO2 max trends over time is what is more interesting to me as I find it a good signal to track long term health and how much overall fitness you're gaining or losing over time.
If this is a topic you're interested in learning more about I've built out this list of factors that influence it as a starting point for anyone to learn more and do their own research. To make this easier I've broken this down by category, included a short plain english definition, and linked all sources (scroll to the right on the tables and you'll see the hyperlinks). I've removed a few from here as it was getting far too long and sorry I know the tables aren't great on mobile but I'll include the full resource in the comments.
Exercise
| Factor | Impact | Study/effect | Plain English | Evidence rank |
|---|---|---|---|---|
| HIIT (long interval, high volume) | Increase | Wen 2019. Meta, 53 RCTs. SMD 0.50 to 2.48 vs control, 0.65 to 1.07 vs steady cardio | Intervals of 2 min+ are the only version that beats steady cardio | Strong |
| Detraining | Decrease | Zheng 2022. 21 athlete studies. Under 30 days ES −0.62 (−3.93%). Over 30 days ES −1.42 (−9.43%) | Under a month off costs about 4%, longer about 9% | Strong |
| Moderate continuous cardio | Increase | Wen 2019. Overall SMD 0.41 to 1.81 across populations | Steady cardio works, it is just less time efficient | Strong |
| Sprint interval training | Increase | Sloth 2013. 19 studies, 13 with VO2max data. g = 0.63 (0.39 to 0.87), +4.2 to 13.4% | Very short all out sprints reliably raise it | Moderate to Strong |
| Resistance training (alone) | Increase | Smart 2022. 37 studies, 22 pooled. +1.89 mL/kg/min (1.21 to 2.57) under 24 weeks. Null beyond 24 weeks | Small bump in over 60s, and only in shorter programs | Moderate |
Nutrition & Supplements
| Factor | Impact | Study/effect | Plain English | Evidence rank |
|---|---|---|---|---|
| Dietary nitrate / beetroot | No effect | Gao 2021. Meta, 73 studies, n=1,061. Submaximal VO2 −0.04 L/min (p<0.00001). VO2max not significant | Makes a given pace cheaper to hold. It does not raise your ceiling | Strong |
| Creatine | Slight decrease | Gras 2023. Meta, 19 RCTs, n=424. ES −0.32 (−0.51 to −0.12) | Adds body water, so the per kilo number dips slightly | Strong |
| Iron (when deficient) | Increase | Pasricha 2014. 24 RCTs, 18 for this figure. +2.35 mL/kg/min (0.82 to 3.88) | Fixing low iron raises it. This is correcting a deficit, not a boost | Moderate to Strong |
| Caffeine | No effect | Brietzke 2017. RCT, n=9. Time to exhaustion +18.7%, peak power +13%, VO2max unchanged | Helps you push harder. Much of the benefit is placebo | Moderate |
Demographics
| Factor | Impact | Study/effect | Plain English | Evidence rank |
|---|---|---|---|---|
| Age | Decrease | Fleg 2005. Baltimore Longitudinal Study, n=810. 3 to 6% per decade in the 20s and 30s, over 20% from the 70s | Decline accelerates with age, and faster in men from the 40s onward | Strong |
| Genetics (trainability) | Variable | Bouchard 1999. HERITAGE, n=481 across 98 families. Maximum heritability estimate 47% | Same training, wildly different response. It runs in families | Strong |
| Dehydration | Decrease | Cheuvront 2010. Mechanism review. Threshold is over 2% of body mass | Less blood volume to pump, and heat makes it worse | Moderate |
| Sex | Variable | Santisteban 2022. Review. 10 to 12% performance gap. Elite women about 10% lower per kg | Mostly oxygen delivery, meaning haemoglobin mass and heart size | Moderate |
| Immobilization / bed rest | Decrease | Saltin 1968 n=5, with McGavock 2009 follow up. −26% in three weeks | Three weeks flat on your back costs about what 40 years of aging does. Crazy. | Moderate |
Lifestyle & Environment
| Factor | Impact | Study/effect | Plain English | Evidence rank |
|---|---|---|---|---|
| Sedentary behaviour | Decrease | Eriksen 2016. n=16,025. No association among the highly active | Matters most if you are not already training hard | Moderate (observational) |
| Sauna bathing (habitual) | Increase | Kunutsor 2024. 2,012 men. +0.30 mL/kg/min per weekly session. Lee 2022 RCT +2.7 (0.2 to 5.3) | A small extra bump stacked on top of training | Moderate |
| Smoking | Decrease | Caci 2025. n=70, step test estimate. 38.8 vs 41.6 in never smokers | Lower aerobic ceiling. Whether quitting reverses it is untested here | Moderate |
| Altitude (live high, train low) | Increase | Wehrlin 2006. 10 elite orienteers at 2,500 m for 18 h/day over 24 days. VO2max 3,515 to 3,660 mL/min | Sleeping high builds more oxygen carrying red cells | Moderate |
| Heat acclimation | Increase | Waldron 2021. 28 articles. Hedges' g 0.42 cool, 0.63 hot. Lorenzo 2010 +5% cool, +8% hot | Plasma volume expands. Clearest when you are also tested in heat | Moderate |