r/trintellix

I’ve been on trintellix since November. The first couple months on it I didn’t notice any weight gain and now with in the past 3 months I’ve gained 15 lbs or more. I haven’t change my eating habits or exercise. In fact over the last month I’ve been eating alot healthier and exercising more but still feel like I’m gaining weight. I’m now really struggling with my body image which I haven’t before. Has anyone who has had weight gain did you go off the med completely or did a lower dose stop that side effect?

Alô Maltinha!

Estou a tomar o Brintellix 5mg há 3 dias para a ansiedade e ataques de pânico e até agora acho horrível.
Sinto me super nauseada durante o dia (tomo à noite ao deitar), e parece que sinto mais ansiedade do que o normal…. E estou muito mais sentimental??? Chorar a toda a hora!
Alguém pode dar algum feedback se isto vai ser sempre assim ou se vai passar? Não me imagino de todo estar com estas náuseas o tempo inteiro….

So came off a cross taper from zoloft 100 mg which numbed me somewhat

Here I am 8 weeks ish into 15mg and it’s a pure hell
Last week doctor wanted to lower me to 10mg cause I was anhedonic and numbed. I did that and he’ll broke loseThe past 4 days I’ve been to the psych ward twice, upped to 15mgwhich doesn’t administer dosis, everything has dissapeared, completely trapped within a chemical prison, absolutely no desire for anything, libido is gone, nervous system is wrecked

Going to private psych ward tomorrow and paid shit loads but I’m havng insane bad reactions

I've been slowly titrating from 5 mg to 7.5 mg to 10 mg. I've now been on 10 mg for 3 weeks, and my psychiatrist wants me to stay there for at least 6 weeks before making a decision. Fair enough.

Since increasing, though, I've thrown up at work several times. I don't feel sick and I don't even feel particularly nauseous. It just comes on randomly. I do take the Trintellix before breakfast so I'm wondering if taking it with food would help with this? Has anyone else had this issue and did it go away?

(M38)
Anybody switched from Effexor or any other SSRI?

Did this medication improved the “brain fog”?
Did it improve the sexual problems?

I’m on a low dose of Effexor- it really does help the depression and anxiety , but the side effects (brain fog, ED) are bad…
I also suffer from ADD - attention deficit disorder.

Thank you guys! I’m really not sure what to do and whether to switch!

I have been taking the medicine for two weeks and a few days. 5mg during the first week and then 10mg for about 10 days. For some time now, I have had many more intrusive thoughts than usual, as well as increased anxiety. Depression, which has always been very well controlled and, frankly, barely existed, seems to have now risen about 5x higher.

Did anyone else go through this in the beginning?

Hi there! Anyone here tried Trintellix / vortioxetine for OCD or other issues and had success? Just started 4 days ago and I am curious about other people's experiences.

Okay, so I understand I’m out my $380+ because I left the pharmacy with them (even though they are not open not even the bag but I get it a safety thing)

But I was not aware of how severe serotonin syndrome could be so now I’m terrified to take the 10mg (I’m currently 40mg on fluoxetine and was going down on it). Can I break the 10mg pill to a 5? I def remember why I stopped it - so expensive. But I didn’t want to just waste the money.

Please let me know if I can break the 10?

For reference - for the past 2 weeks I’ve been taking a 5mg with my fluoxetine so I don’t see anything wrong keeping it at that. Just please send help before I panic even more over this

Will I feel anything with 150ug

I’ve been on Trintellix for 3 weeks. 5mg and 10mg were fine. But 20 mg (taken for 1 week) causes muscle weakness. Even typing this, I feel my forearms getting tired. When I exercise, I get hotter faster and fatigued much sooner. The fatigue is in the muscles, not the lungs.

Will this improve over time? I don’t want to reduce the dose because my mind seems to need it.

Iv so far not seen any benefits I feel worse and have dpdr from this so bad

Last 3 days im stuck in bed literally zero energy and feels like my brain is full up.. very dark thoughts too

And I havenet just started its been 4 weeks

15mg 10 days

10mg one week

The other lower doses

I take it this is not going to work for me as I feel awful? Really dark hole

Those who took it specifically for apathy and/or anhedonia and experienced an improvement, at what dose did it work?

I had a conversation with Gemini on the mechanisms of this medication and concluded that higher doses could be counterproductive, so more would not necessarily be better in this case (of course everyone is different)

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So I have been having really bad anxiety for months which caused severe depression crying all the time, hopeless, extreme agitation etc

I started trintellix after other meds havent done much

But I feel like depression is changing form

Now

- Absolutely zero energy like my brain and talking is such an effort and slowed.

- Not crying but, not anything much. Have no energy at all

- Feels like I cant even think to ruminate to tap into anxious thoughts etc

- Head full of pressure where before it felt empty

Does this mean getting worse, improving or nothing?

Have been on 15mg for 10 days now

10mg for a week

5mg for the rest

This depression has hit me harder than ever. I can barely move out my bed I have no energy at all its like all my dopamine has tanked massively

I got given lamotrigine last week took 4 doses and stopped as felt totally out of it.. maybe its also that?

I feel like vortioexitine should be doing something positive by now. Im completely low

I knoww mixing medication and alcohol isn’t the smartest choice but I’m on vacation and want to live a little. I had 2 drinks at dinner. Then we went to the bar and I had 3 more drinks. I still don’t feel like I drank anything at all. I only drink occasionally and have always been a bit of a lightweight. If I had 5 drinks in one night before Trintellix I would be almost blacking out. Just wondering if anyone else has noticed this.

Hi guys. I got taken off of Trintellix.

I was on 10mg and did 2 weeks of 5mg, and stopped.

It sounds normal, but I've also been having a lot of work related complications and I'm being picked on and bullied. This doesn't help the whole coming off of anti depressants situation, either.

I do realize I've been way more paranoid about things lately than I should be.

I think I'm experiencing psychosis.

Two weeks ago, I raised my voice at a coworker who was baiting me into a reaction and it went south and got tense from there. Some coworkers have been picking and acting weird since then.

But I also think I may be experiencing heightened paranoia / psychosis.

Example: something I use to work with went missing. I never misplace these, I haven't in three years of working at my job. I looked at home, in my car, everywhere. They're nowhere.

I feel like someone may have taken them.

Has anyone experienced this? Please help. I'm scared.

I am someone who menstruates, and Advil is the only thing that even touches my cramps. Generally only need it for the first few days of my cycle, but it is definitely pretty necessary for me. Am I genuinely doing myself harm by taking Advil? Any insight is appreciated. Tyia

I am a 32yo male diagnosed with ADHD & ASD1, I have been taking concerta for years but recently I was diagnosed with depressive disorder and given vortioxetine, 10mg. I'm now on month 3 of taking it. The situation got worse, and then it got way better.

· Weeks 1&2: Minor nausea, minor placebo effects, nothing special

· Weeks 3&4: Negative effects started building and peaked here. Bad sleep, depression got worse, I regressed as a person. No self-care, no ability to enjoy things

· Month 2 (weeks 5, 6, 7, 8): Negative effects slowly started to disappear. Sleep fixed itself, no nausea. Positive effects started building

· Month 3: Good sleep, good mood, desire to self-care, desire to clean, simple joy, less rumination, it takes less for me to recover now

This is all my personal experience. During weeks 3 and 4 I thought of stopping, but I was able to hold on because of success stories that I read in this subreddit. So I held on. And just like other people said, after some shaky times the situation just started to flip completely. I've been running on fumes for a long time, but right now on month 3 I feel closer to other people. I ruminate less, things do less "mental damage" to me, I can recover quickly, I can look for a job, I can study.

My life is still very much the same as it was on the outside, but it's very different now inside of my head. Take this as anecdotal evidence, not medical advice. The stories of "it got worse and then it got better" do indeed happen. And if it's not with vortioxetine for you, you will get there perhaps with another med.

Don't give up your quest for a better life, however painfully slow it feels. Progress can be made. It can be better. Have a good day

Hi everyone, I have just started taking vortioxetine for my anxiety and found it also interacting with my OCD. As my anxiety tends to be fuel to my OCD, although I am only 5 days in, I am noticing a small but definitely noticeable improvement to my compulsions and the intensity and frequency at which they come about because of my intrusive thoughts.

I have been experiencing some things such as nausea, some headaches, a feeling that I am about to vomit, and mood swings/ my anxiety seemingly disappearing by probably 90%. I feel that I am switching moods quite rapidly, and have a mood where I experience an extremely happy, positive and motivated feeling, basically a euphoria. I also feel a fuzzy feeling in my mind.

Does anyone else have any experience to share with their OCD and how it interacts with this medication and vice versa? It would be really interesting to hear. Thank you!