r/trintellix

I’ve on day 7 and started experiencing about 3 to 4 days in and it has gotten worse daily. It’s nonstop and I’m literally bruising myself itching. I’ve tried Allegra and truamcinolone. Neither have helped. I got Sarna calm and cool today and that offered some relief just very brief and I feel like I’m halfway through the bottle already.

Do you experience any itching? How long did it last? And how long did it take for you to feel the effects of the medication? I can’t even tell if it’s helping with my anxiety breach because I’m still preoccupied with itching.

Hi people!! First time posting here!! I want to told an awful experience i lived with Trintellix 9 months ago.

I will start from the beginning.

I suffer from anxiety and obsessive thoughts related with illness since i was a young adult (20yo) and i went with sertraline 50mg at that time. That med worked very well for my anxiety but i suffered from a mild emotional blunting and the worst sexual dysfunction ever, this carried me a lot of problems with sexual partners and girlfriends, that's what my psychiatrist decided me to put on Trintellix, just telling me that this med had a better sexual profile. I started with a dose of 10mg, experiencing a lot of weird things like cognitive impairment, unability to focus on my studies, apathy and a lot of fatigue, not very useful with anxiety, that's why he tried to increase the dose on 15mg telling me that my anxiety will improve but my symptoms get worse and sexual dysfunction came again.

I read a lot of clinical information about Trintellix during my treatment explaining that due to his long life i could go cold turkey cause my body will do a "natural gradual tapering", worst mistake of my life.

Just like 1 week later i'll felt fine and i explained my psychiatrist that i cold turkeyed vortioxetine and he said "ok, it's up to you, you know what you're doing", which i think now that was a big neglicence by him.

Months passed with mild fatigue and anxiety, experiencing the same emotional blunting when i was on 15mg (unability to cry or laugh genuinely,...). At the month 6 i started to experience wild palpitations after the nap which was frightening but i thought were part of the process, later some tinnitus came intermittently. Was finally when at month 8 after one anxiety episode i've suffered the worst experience of my life. Huge despersonalization, tinnitus and palpitations 24/7, can't even sleep for 3 days, extreme anxiety and the worst of all, akathisia. I just wanted to kill myself to end this suffering. After this, i've reinstated vortioxetine knowing that probably i would need the same med to stabilize myself and the receptors that are modulated with trintellix.

I was put on 10mg again and i experienced a completely different experience comparing to the previous crisis treatment. Big activation, mood swings, anger issues,... I almost punched my own father.

Now after tapering 1mg every month with another psychiatrist (4mg now) im so much better but not recovered yet, my goal is to get rid off of this medication. Definitely not for me.

Hope my experience will be useful to remember that cold turkey an antidepressant is NEVER a good idea, specially with trintellix that affects other systems due to it's multimodal profile.

Take care of yourself and thanks to read this.

Pd: want to apologize myself for my grammar, not a native english speaker.

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Hi Everyone,

I’m a 26 year old male and have been on Zoloft 50 mg. Mentally, it’s worked really well for me, but the sexual side effects have been frustrating. I’m able to get an erection, but keeping it was sometimes difficult, and even when everything worked it could take me up to an hour and a half to finish.

My doctor added Wellbutrin, which definitely helped with maintaining erections, but it still takes me forever to orgasm.

Now my doctor is weaning me off Zoloft and switching me to Trintellix. I also take Adderall XR 10 mg for ADHD.
For anyone who has taken Trintellix, especially after Zoloft or another SSRI, what was your experience like?

Did your sexual side effects improve? How was it for your mood and anxiety? Any side effects when first starting?

Would love to hear both positive and negative experiences!

My psychiatrist has prescribed me Brintellix (10mg) as a substitute for Duloxetine (30mg) as the latter gave me sexual dysfunction (I am a woman in her mid 20s).

I noticed that I am quite sensitive to SSRIs and SNRIs, especially the sexual dysfunction aspect. It is a nightmare.

What are your guys' experiences with vortioxetine and sexual dysfunction?

I have been on Brintellix 20 mg for a year now. However, in the past 6 months I have noticed increasingly aggressive thoughts (not acts). For example sometimes when I feel frustrated of something I think is wrong in society, I momentarily think it would be nice if there was a total rebellion or a riot made by people. I do immediately realize the idea and fantasy is stupid but these thoughts do surface much often than before Brintellix. Also I did not have these thoughts when I had a short break from Brintellix.

Well, my depression has only gotten worse because after I got this prescription there has been a lot of negative events in my life. So it can be that too. Also I feel this drug has made my comorbid anxiety disorder worse. But has anyone else felt this "aggressiveness" even past first months of use?

Sometimes I just don’t want to do anything, have trouble task switching, like I’ll sit in my car for ages scrolling, and struggle with motivation

At the same time my head is clearer and socialising is easier, but I’m not sure this is worth the trade off

Was anyone else still having side effects like this at 3 weeks and does it settle?

Has anyone had better success on 5mg Vortioxetine instead of a higher dose? (10mg is causing too much side effects after a month)

My doctor prescribed me Trintellix yesterday. I went to pick it up and even ater bc/bs insurance, my cost is still over $500. I got a prescription card from the Trintellix website and it got it down to $411. For a med that we are trying and don’t know if it’s going to work yet, are there any other options for prescription discounts for this med? I understand it’s still brand name and doesn’t go generic until the end of this year possibly, I’m just looking for options now.

I've never been on any medication before...so, I don't know what to expect. I'm only on day 2 of 5mg of Trintellix...and an hour after I took a pill on my 2nd day...out of nowhere, while I was working, I uncontrollably started crying for about 15 minutes. I had to stop work. I fell to the ground and just stared and cried not understanding what was going on. I usually have very clear triggers for my PTSD but I don't know how this happened. It eventually stopped but now my brain is foggy and I feel a very weird tingling sensation throughout my entire body. To say I'm scared and that I want to stop this medication is an understatement. Has this happened to anyone else?

I’ve been taking 10mg of (brand name) Trintellix since April, and it’s been the only medication that has really helped me. The problem is that I’ve had extreme nausea since the very first night I took it, even though I’ve always taken it after dinner/a meal and before bed.
I’ve been managing the nausea with ondansetron (zofran), but I’m currently running low and haven’t been able to get in touch with my prescriber to renew the refill.

For those who experienced significant nausea with Trintellix, did anything actually help reduce it over time?
I’m looking for things I can try while I’m waiting to get in touch with my prescriber.

I really don’t want to stop Trintellix because it’s been helping me so much, but the nausea can be pretty debilitating. Any advice would be appreciated!

I’ve on day 7 and started experiencing about 3 to 4 days in and it has gotten worse daily. It’s nonstop and I’m literally bruising myself itching. I’ve tried Allegra and truamcinolone. Neither have helped. I got Sarna calm and cool today and that offered some relief just very brief and I feel like I’m halfway through the bottle already.

Do you experience any itching? How long did it last? And how long did it take for you to feel the effects of the medication? I can’t even tell if it’s helping with my anxiety breach because I’m still preoccupied with itching.

My wife started taking trintellix about 5 months ago, she is on the 5mg dosage. For the first 4 months it was what I considered a wonder drug, she was happy she was sad and everything in between but it wasn’t what it was prior to SSRI. Over the last month she has been angry with anyone and incredibly sad. She wants to stop the medication because she believes the fighting with people is stemming from that, I think it could just be adjusting still idk what to do but I don’t want her to be in the depressive bout she was in prior to SSRI. Has anyone had this happen to them on this medication and is there light at the end of the tunnel?

For reference she has tried Zoloft & lexapro, both of them she disliked for various reasons but this one was amazing minus slight nausea.

Comecei a tomar vortioxetina no dia 5 de agosto de 2026, vou em 5 MG, estamos no dia 18 de agosto de 2026 e não sinto diferença absolutamente nenhuma.

É normal?

As pessoas que tomaram ou tomam, quando é que sentiram alguma diferença?

Hello

I’ve been taking it for almost 6 months for depression, anxiety, panic attacks and OCD.
It helped a little with my depression, like it took the edge off, but I’m still depressed and I still find myself every day wondering what the meaning of life even is.
I’m also still anxious and dealing with constant existential OCD and cardiophobia.
At this point I honestly feel like damaged goods lol. Has anyone else had a similar experience?

On my second go-round with Trintellix. It worked well back in 2023...for about a year...and then abruptly seemed to stop working. Giving it another try, but this time, in addition to sweating and nausea, I have this near-constant desire to eat. I'm not HUNGRY. I just WANT TO EAT. Even with the nausea! Has anyone else experienced this?

Took 5mg at night and it caused constant waking at night, so I switched to the mornings but it’s still affecting my sleep. On day 5 currently and wanting to quit already because of this🥲

As a 60-yr-old female, I been on Trintellix for 6 years. After reading other Trintellix testimonials, I now realize there is a possibility my lack of motivation, lack of libido, excessive weight gain (more than ever) has been caused by Trintellix. It's changed my life for the worse. After consulting with my doc, I'm going to taper off. It's really kept me down. I don't want to go anywhere or be around anyone like I use to. Wow. Thanks guys for giving me a heads-up about one of my crazy pills.