u/barweis

https://cre-paving.org/long-covid-conferences/lcc-2026/registration-2026/

"National Health and Medical Research Centre: (cut and paste) The Centre of Research Excellence PAVING: Post-Acute Viral Infection diseases Group is a multi-million-dollar research centre funded by the National Health and Medical Research Centre that unites recognised experts from La Trobe University, The University of Queensland, Monash University, QIMR Berghofer Medical Research Institute, The Walter and Eliza Hall Institute of Medical Research, Murdoch University, Griffith University and Deakin University with a shared goal to improve patient outcomes.

Centre of Research Excellence PAVING is the Southern Hemisphere’s first centre to unite world-leading researchers, clinicians, and lived experience advocates to uncover shared immune response dysregulation behind post-viral conditions to accelerate the development of effective treatments and clinical interventions."

Below are some of their publications on LC19 and ME/CFS and more. Till now, it seems, their work does not appear currently in many of the main subreddits for IACC issues. So skim the list and follow your interest.

https://cre-paving.org/publications/

As an avid and opportunistic surfer over the internet I came across this gem of an article, 1), that can be extrapolated to certain conditions as evidenced by the publications below it.

AI was used only in launching the research inquiry. The body of the post is purely my composition with any errors solely the product of my quirks. If the structure is awkward it proves that I am human.

1. (https://www.sciencedaily.com/releases/2026/07/260724061448.htm)

Apropos of LC19 treatment are dysbiosis, and associated gut leakage phenomena of chronic inflammation from translocated microbes and nocive extracellular vesicles. Intake should foremost be from sources among which figure the following foods contained in these articles:

2. https://www.medicalnewstoday.com/articles/318593 What to know about inulin, a healthful prebiotic

3. https://www.sciencedirect.com/science/article/pii/S0022316623021065 Presence of Inulin and Oligofructose in the Diets of Americans1

4. https://pubmed.ncbi.nlm.nih.gov/41155411/ Microbiome and Long COVID-19: Current Evidence and Insights

Barring those unable to ingest nature's produce, prudence is required when taking synthetic or artificial sources using the principle of start low and go slow. Applying that in practice involves initial dose of minimal product, advancing weekly with single increments till a plateau is attained or symptoms arise to cause the patient to back off till they resolve. Then remain there for the duration. This is necessary to allow the active gut microbiome to regroup with a different composition sympathetic to the needs of the patient provided such be the outcome.

....................

From article 2): ["Safety and side effects Researchers have studied the different forms of inulin extensively, and it appears to be safe for most people in small doses.

However, people who are intolerant to FODMAPs are likely to experience significant side effects.

Those who are allergic to ragweed may also experience worsened symptoms after taking chicory inulin. Additionally — and very rarely — people with a food allergy to inulin may experience anaphylaxis, which can be life-threatening.

When adding inulin to the diet, start with small amounts. Larger amounts are more likely to trigger side effects. Increasing intake slowly over time will help the body to adjust.

The most common side effects are:

flatulence (gas) bloating abdominal discomfort loose stools and diarrhea For example, studies have shown that oligofructose — which is related to inulin — can cause significant flatulence and bloating for people taking 10 g per day (31Trusted Source).

People can generally take inulin from chicory root at higher dosages, but some people reported slight stomach discomfort at 7.8 g a day )."; https://www.medicalnewstoday.com/articles/318593#side-effects]

....................

From article 1): "When these bacteria consume inulin, they produce short-chain fatty acids (SCFAs). One of the most important is butyrate, a compound that can affect inflammation and the biological pathways involved in pain throughout the body.

Participants who received inulin had higher levels of both butyrate and glucagon-like peptide-1 (GLP-1) -- a gut hormone associated with pain regulation and muscle health. Increased GLP-1 levels were also linked to better grip strength, suggesting a possible connection between gut health and muscle function that researchers believe deserves further study."(end of excerpt)

.........................................

My comment:

As an aside, SCFAs stabilize the ECM- extracellular matrix which provides the background substrate for all the body's solid structures in which reside multiple populations of cells including Mast Cells, a.k.a., "wonder cells". For the present it is enough to relate that SCFAs reduce the inflammatory output of MCs.

5. Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling https://pmc.ncbi.nlm.nih.gov/articles/PMC7703657/

6)Butyrate, Valerate, and Niacin Ameliorate Anaphylaxis by Suppressing IgE-Dependent Mast Cell Activation: Roles of GPR109A, PGE2, and Epigenetic Regulation https://academic.oup.com/jimmunol/article-abstract/212/5/771/7926093?redirectedFrom=fulltext

YMMV.