r/Semaglutide

We moved provinces last year and still haven't been matched with a family doctor. Every walk in clinic I've tried says weight management isn't something they handle, which I sort of expected but it's still frustrating. I know telehealth exists. I just can't tell which of these platforms are reputable and which ones are not.

Im currently on Wegovy. 6th week in.

I took the 0.25 injection for the first 4 weeks.

Im currently on the 0.5 injection.

Im having little to no side effects.. but my appetite is HEAVILY suppressed. It was heavily suppressed on even the 0.25 injection, which I am fine with.

When i wasked about refills, my doc told me that the will keep increasing the dose every 4 weeks... and if i show negative side effects to back down to the prior dosage.

My question is, if Im losing weight, not having any ill side effects, and my appetite is suppressed, can I suggest to my doctor to just keep me on the same dosage? Or is there something more I should be expecting as the dosage goes up. I'm a very analytical person.

I take the shot.

Shot suppresses my appetite.

I dont feel sick

I lose weight.

???????????

---------------

Period. So why up the dosage unless the hunger comes back?

Thanks in advance

I am on semaglutide I started at 224 and im only down to 221 im on 1.0 dose now. I eat way less. Like I will start eating a meal and not finish, periods have become regular and I feel less bloated. Does it make a difference that I have PCOS. I feel like by now I should have been down way more. Am I crazy ? I feel so hopeless with this whole journey.

don’t want to sound dramatic but I’ve been on semaglutide for exactly 3 weeks. I’m down 12.4 lbs (5.8% of my body weight). It has changed my life. It took me 3 months of grinding and killing myself last summer to lose 12 lbs. Since taking this a few weeks ago it has honestly made it a breeze to be healthy. No food cravings, no alcohol cravings, plenty of energy and no side effects. I am eating about 700-1200 healthy calories a day and I’m completely satisfied and shedding weight. If this continues I will be the biggest advocate of it to everyone that’s ever struggled with their weight. If anyone is hesitant please go for it, I was extremely hesitant for a long time. Feel free to ask me any questions. I am a 5’10 mid 20s male, former college athlete and gained about 40 lbs after college to 220.

I was diagnosed with PCOS/PMOS in 2019.
I’m 28 years old, 152 cm (5’0”) and 64 kg (141 lb), and I’ve struggled with my weight pretty much my whole life. Losing weight has always been extremely difficult for me. I’ve tried many diets and even tracked my calories consistently for years, but the scale barely moves.

For years, my gynecologist basically prescribed me the pill and told me to try to lose weight. I’ve also tried metformin multiple times, but the stomach issues were always bad enough that I had to stop.
PMOS has affected me beyond my weight. I often feel extremely tired after eating because my blood sugar was crashing, which makes it difficult to concentrate and work. I’ve also had irregular periods and ovarian cysts. Hair under my chin. I also had PMDD at the start of my diagnosis.

I finally decided to see an endocrinologist. She ordered comprehensive blood tests and an ultrasound. Pretty much everything came back normal except for my HOMA-IR, which was high and indicated insulin resistance.

We tried metformin one more time, but my stomach still couldn’t tolerate it. My endocrinologist then prescribed Wegovy 0.25 mg, and I’ve now been on it for 5 days.

I’m hopeful, but also pretty anxious. I’m scared it won’t work for me or that the side effects will become too much and I’ll have to stop. After struggling with this for so long, I’m afraid of ending up back at square one.

So far, I’ve had some gas and constipation after breakfast and acid reflux after dinner. It’s manageable, but I’m wondering if this is just my body adjusting since I’ve only just started.

For those with PCOS/insulin resistance who have taken Wegovy or another GLP-1: did your side effects improve over time, and did the medication help with your insulin resistance symptoms as well as your weight? Did you eventually come off it, or is this something you expect to take long-term?

I know everyone is different and I’ll discuss the medical side with my endocrinologist, but I’d really appreciate hearing your experiences. It would help ease some of my anxiety about starting.

TL;DR: PMOS + insulin resistance, couldn’t tolerate metformin, and just started Wegovy 0.25 mg 5 days ago. I’m having mild gas, constipation, and acid reflux and I’m anxious about whether it’ll work, whether the side effects get better, and whether I’ll need it long-term. Would love to hear your experiences!

Let me be clear- I am NOT on this for appetite suppression- I have no trouble eating less. The issue is I get hypoglycaemic reactions when I go low calorie, I have a fatty liver, pcos, inflammation and high BP. I noticed on .25 I was able to keep the lower calorie intake I already was on but without blackout feelings or tremors which was a relief, but while weight loss is good it is the fatty liver I really worry about- is this level enough to help clear the liver and lower inflammation? It seems to have helped with my insulin already

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Start : 27/07/26 Monday | Wt: 120.8 kgs 1st

29/07/26 - 119.7 kgs

03/08/26 - 119.6 kgs 2nd

04/08/26 - 119.4 kgs

05/08/26 - 119.2 kgs

06/08/26 - 118.7 kgs

07/08/26 - 119.0 kgs

09/08/26 - 119.2 kgs

10/08/26 - 119.1 kgs 3rd

11/08/26 - 118.9 kgs

12/08/26 - 118.3 kgs

13/08/26 - 117.7 kgs

14/08/26 - 117.7 kgs

17/08/26 - 117.9 kgs 4th

19/08/26 - 119.3 kgs

On 0.25mg dose. Someone please explain the increased weight. Also, not feeling the same appetite suppression as in Week 1 and 2.

I'm just wondering if there's anyone with a significant amount of weight to lose and just aren't losing weight?

I'm currently 459lbs, I know how to lose weight, I've lost over 200lbs thus far and just needed more help for the rest.

I'm female, 6ft and started Semaglutide 5 weeks ago.

The first week my weight dropped a huge amount, I went from 474 to 460lbs. The past 4 weeks though, nothing. I drop 1lb and go up 1.5lbs, drop and go up, I got down to 452lbs and then put on weight ever day until I got back up to 459.

I'm in a massive calorie deficit, I am still on 0.25mg, I know it's not the 'weight loss dose' but I have no desire to eat, and I'm full after small amounts of food and have been since the first day.

I'm tracking my calories, and most days getting in between 1100 and 1500 calories, with around 120 - 160g of protein - I would like to be eating around 2000 calories, but I'm just too full really to be able to get them in.

I have been working out for years, so it's not new to me. I strength train 6x a week. I also do a boxing class 3x a week, a spin class 2x a week and swim 2.5k - 3k 4x a week - I genuinely don't understand why the scale just doesn't seem to be moving. I have a massive amount of weight to lose, I'm tracking everything I eat, I'm moving my body... and yet I'm in a war with the scale.

So, really I'm just wondering if there are any other people here who have had a huge amount to weight to lose, doing the things right and it just doesn't seem to be working at all, even though the medication seems to be doing its job.

I’ve been in tirz for 3 months now I am with brello and they started me off at 2.2mg then 4.4 then 6.6. I haven’t lost ANYTNING! So I skipped 6.6 and started taking 8.8 after 4.4. So I’m on my 3rd shot of 8.8 and still nothing. Food noise is horrible, I’m still hungry and it’s hard to stay within a deficit. Starting weight 330. Current weight is 332… not sure what I’m doing wrong. I don’t want to renew with brello as now I’m thinking something is wrong with the meds they’ve been giving to me. I’m considering Reta & going back to semaglutide. I took sema from amble last year and was losing weight my very first month and the starter does for that was .25 and I lost 50lbs in 3 months. Yes I was sick as a dog and had horrible nausea and diarrhea but the weight was dropping so fast and I did feel good mentally, zero food noise!! I’m considering just going back to sema.. any advice?

I started the GLP1 journey on sema and had some pretty decent success. Was on it about 3 months losing about 25lbs so on the higher end of about 2lbs a week. Around this 3 month mark at 0.75mg dose I went on a vacation which included heavy drinking, and on return my doctor wanted a blood test since I was on the medication 3 months and my liver enzyme levels were abnormally high so he pulled me off the medication to see what was going on and if sema was not the cause. Levels returned to normal and a month later I was back on sema, but the doctor said since i was off for a month I have to restart at the 0.25mg dose again. I figured since I am starting from the beginning, lets try tirzepatide.

Switched to tirz and it has been 3 months so far, I am up to the 7.5mg dose and have seen very little progress. Progress being so slow I have been ultra careful about my diet and exercise and I am starting to wonder if the medication is even helping or if me being super careful about my diet and exercise is really what is making the scale change. On sema, I didn't even have to pay much attention to my diet, I wasn't making poor choices but just eating normal had weight coming off.

Overall I am thinking of switching back to semaglutide to see if that helps. I was curious if anyone else has done the same and if they have experiences they can share.

I’ve been on 0.25mg for about 5 or 6 weeks now, staying at this dose for a conservative amount because my appetite has lessened and I wasn’t really getting side effects. But as of about a week ago, I’ve been getting nausea on and off, usually long after a meal. Sometimes I can guess food may be a culprit, but usually I don’t feel effects until hours later. Is the food likely the cause? Is this normal on such a low dose?

can anyone tell me about their experience using xanax and sema? How did sema effect your mental health?

I've taken only the reduced dosage samples for ozempic they give out to get you acclimated to the side effects while my insurance was processing my pre-authorization. Unfortunately, my insurance denied me coverage, despite my doctor's best efforts, but since I've gotten off of it, I've noticed that none of my bad eating habits or appetite returned. In fact, I've been losing weight pretty consistently over the past several months without too much trouble. Did anyone else experience this?

I’ve been experiencing some strange side effects(?) and was wondering if anyone else has had the same experience.

Basically, while food is no longer interesting to me, I’ve become absolutely obsessed with cleanliness and smelling good. My house has never been cleaner, and while I used to struggle to wash my hair every day, I now do, and have even cut off all my long hair so that I can feel even fresher and cleaner. My car is sparkling, my sheets are now washed every week, and I have become obsessed with good smells. I go into Lush just to huff the products. I wouldn’t say I was unclean or slovenly before but this is on a whole different level. It’s not something that causes me distress. I actually get a feeling of euphoria and a dopamine rush from cleaning and taking everything showers now. Has anyone here experienced similar or knows what I’m talking about?

Down a decent amount since spring and the thinning is the only side effect that has actually bothered me. I have pushed protein up and it has helped a little but not enough to stop me noticing. I do not want to stack five different things and then have no idea which one did anything. If you dealt with this, what did you add and did you give it a full three months before judging it?