r/Spironolactone

Hi everyone! I'm a 32-year-old woman struggling with significant hair loss, and I'd really appreciate hearing from women who have dealt with something similar.

I was diagnosed with Sjögren's syndrome at 24, and my hair loss has been particularly noticeable since then. My crown is the most affected area — it's very flat, with visible scalp and significantly less hair than the rest of my head. I also have thinning in other areas of my scalp, but the crown is by far my biggest concern.

I'm considering asking my doctor about low-dose oral minoxidil and oral spironolactone to help manage the hair loss and hopefully regrow some of my hair.

However, there's one major complication: I consistently have low blood pressure, usually around 96/74 or 100/60 mmHg. I'm worried that both medications could lower it further and cause dizziness, fainting, or other problems.

I'd love to hear from women who have experienced hair loss alongside an autoimmune condition, particularly Sjögren's syndrome, or who have used either of these medications despite having low blood pressure.

A few questions:

• Has anyone with naturally low blood pressure taken oral minoxidil for hair loss? How did you tolerate it?
• Has anyone taken spironolactone with low blood pressure, and did you experience dizziness, weakness, or fainting?
• Has anyone taken both medications together? What was your experience?
• Did either medication help with crown thinning and visible scalp?
• If these medications weren't suitable for you, what treatments helped you achieve meaningful regrowth?

I intend to discuss this with my doctor rather than self-medicate, but I'd like to understand other women's experiences and what questions I should ask at my appointment.

I'm particularly interested in hearing from women who started with significant crown thinning and managed to improve their hair density.

Thank you! ❤️

I know loss of libido is a side effect of this drug, but I didn’t realize that meant possibly longterm?

Two years ago, I took this medication for a brief few months and ever since then I have not felt any sex drive nor anything from my libido. For context, prior to this medication, I was so hypersexual I was literally diagnosed with it. I’ve gone from feeling everything all the time, to having absolutely NO desire ever? Drier than a Sahara desert. It gave me a rocking body but I didn’t realize it would cost this.

I’ve had my bloodwork done, I’ve seen a gynae. All she did was brush it off and tell me it was psychological and impossible to still have side effects at this point?

Has anyone else dealt with this? Is there any way to fix this? I’m genuinely so frustrated :(

Spiro has saved my skin, but I’m afraid its wrecked my puss. Has anyone else experienced vaginal dryness or an inability to ~get wet~ when horny or self-lubricate during sex? I’m talking with my doctor about using a topical .2% estriol cream to see if I can get things going down there again, since she’s unwilling to prescribe me actual estradiol at 28 years old.

I know spiro dries you up and all the androgen effects are probably the culprit, especially bc I’m on a very high dose (200mg). My acne is stubborn and comes back whenever we try to lower it.

Any experiences/familiarity with this problem or potential solution would be sooooo helpful!!

please tell me i’m not the only one who has the most insane boob pain. like a light breeze upon my nipple could kill. they’ve also grown quite a bit and i have hyperpigmentation around them. has this happened to anyone else?