r/Spironolactone

Skin progression on tretinoin and spironolactone after 5 months, requesting help
▲ 7 r/Spironolactone+1 crossposts

Skin progression on tretinoin and spironolactone after 5 months, requesting help

Pictures are from January(top) and today(bottom). I’m at a point where I don’t want to leave the house because I can feel it getting bad again. I’ve been battling this for 2 years after my random second puberty at 26 years old.

Evening Routine:
- 50mg spiro
- anua heartleaf oil cleanser or jojoba oil
- tribe skincare vitamin C facewash
- red light therapy
- 0.025% retin-A tretinoin cream
- vanicream moisturizer

Morning Routine:
- 50mg spiro
- cold water
- 10% azelaic acid, 3x a week
- vanicream
- sunscreen

I also work out 4x a week. Drink PLENTY of water. And (atleast imo) maintain a good diet. I don’t always get 8 hours because I work extremely long days but never less than 6. I also changed out my shower head to a filtered one.

I’m not understanding what I am doing wrong. Thank you so much for your help.

u/Firm_Note_2351 — 17 hours ago

Help?

Hi, 👋🏼 I’ve been on Spironolactone for about 2 & 1/2 months and my skin has only gotten worse and so much worse as far as texture goes. Is it worth it to keep trying it? I went up on the dose 3 weeks in.

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u/Suspicious-Sky-1208 — 17 hours ago

Taking spiro only during luteal phase for hormonal acne

does anyone have any experience with taking spiro only during the luteal phase for hormonal acne?

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u/OneGur1434 — 16 hours ago

Oral to topical

Hi!

I was wondering if anyone here has switched from the tablet to topical spiro? Did you have a purge? How long did it take for your skin to adjust? Did you have side effects coming off?

I’ve been taking the tablet for two years and it’s worked wonders for me. I just don’t want to take an oral medication forever, you know?

Any info would be appreciated! TIA :)

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u/dance-lil-liar — 17 hours ago

Spironolactone causing bleeding 10 days after period ended?

I’ve been on spironolactone 100mg for 1 month now. I just finished my first pack and started the second one. My normal period ended about 10 days ago, but now I’m bleeding again.

It’s not super heavy, but it feels like a regular period and it’s been going on for 3 days now. Has anyone else experienced this when starting spironolactone 100mg? Did your cycle eventually regulate? I'm kinda very scared and stressed now..

Just wondering if this is a common side effect in the beginning or if I should be concerned.

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u/Smooth_Cancel6709 — 1 day ago

Purging without previous acne issues

I started 25 mg of spiro because I was getting unwanted chin hairs (38F). I had acne until my mid 20s and have been mostly acne free since. I have a solid skin routine and don't have many issues. But suddenly my entire chest has broken out. Along with some on my back and face. I am NOT thrilled. I haven't had to deal with this in a loooong time. Any advice on how to clear it faster? I took a break from all my "extra" skincare stuff, like the various acids and creams I usually use. Going basic with double cleansing and just moisturizer. Took a break from tret, but maybe that's a mistake? Ugh. I hate this so much. So much for a hot girl summer. 😭

u/Usual-Jackfruit4746 — 23 hours ago

Any women with PCOS also not gain weight on this drug?

I’m on 75mg. Been on it since January. I gain weight exceedingly easily. No issues with this drug whatsoever. I’m not on metformin or any weight loss drugs. I’ve just been fine… able to gain easily as always but very conscious of it.

Im just starting to try losing preexisting weight I had gained before the spiro so maybe that will be more difficult on the drug. We’ll find out

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u/anononononn — 1 day ago
▲ 33 r/Spironolactone+1 crossposts

Permanent Body Changes?

Hi everyone,

About a year ago I tried spironolactone for hair and acne. I noticed after the first few weeks that it started changing my body and weight. I used to be athletic and fit (I’m a woman, 32 now). I noticed loss of muscle mass and a more feminine physique, weight gain, larger breasts and hips, stomach, cellulite. Never had that in my life, always been an athlete.

I stopped taking it.. a year later no matter what I do I can’t lose these 20 pounds or the body changes. No matter what I eat, how much working out.

Any advice on what to do? I saw a few posts and articles that it permanently can change your alleles?

Has anyone else seen this?

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u/West-Hedgehog5794 — 2 days ago
▲ 4 r/Spironolactone+1 crossposts

Wondering about spiro and this loss pattern?

Has anybody had this type of hair loss on spirolactone? Or just in general? I got diagnosed with AGA about two years ago, and initially my hair loss was all in my crown and top of my head, not really anywhere else. I got on OM minoxidil and spirolactone about a year ago, the crown of my head has gotten all filled in but since I started Spiro I began having loss around my ears, temples, and the back of my neck. Now I’m losing it on the hairline down the middle of the back of my scalp. I began Spiro in February of 2025 and that’s when I began to notice the thinning on the neck and sides. It hadn’t really stopped since. And it gets worse each time I increase my Spiro dosage which my derm keeps telling me to do. She keeps telling me that Spiro doesn’t cause hair loss and that can’t be it. I understand that AGA progresses but this is a very unique loss in specific areas and it’s completely different from how my AGA loss presented before starting the med. I’m feeling like I need to do something different, maybe go off of Spiro but I’m afraid. I lowered down from 100 to 50 about six months ago and it didn’t really do much, maybe slowed things a little. I take 2.5 mg OM, do red light therapy and iron, pumpkin seed oil, and saw palmetto supplements also. Any help or advice would be appreciated!!!

u/FamousIntroduction76 — 2 days ago

Spirnolactone while working nights

Hey all. So im a night shift (12 hrs) MA working in a hospital with a different schedule each week. I was prescribed spirnolactone for my acne and am not sure when is the best time to take it with my unpredictable schedule and sleep patterns. Can anyone shed some light if they have had this experience and what worked for them.

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u/Laughygirl98 — 2 days ago

Shocked looking back at how well spiro worked for me

First photo was from a year and a month ago. Second photo was taken a few days ago. I got my prescription for 100 mg of spiro daily about a year ago and have been consistent with it ever since. My skin isn't perfect but I essentially don't really have acne anymore. First pic is how I would get around my period and/or if I had any extra stress or lack of sleep. I was used to it but looking back now, it's crazy how much hormonal acne and scarring and scabbing I was always dealing with, since I tended to pick at it a lot. I seriously have taken for granted how much clearer my skin is now and how my oil levels are controlled.

I also am very consistent with a low maintenance skincare routine, just CosRx Eye Cream, Midha Rice Lotion and/or Cetaphil Sunscreen moisturizer and Midha Rice Bran Face Wash daily. All of that has helped my skin be more glowy too. But spiro has made the biggest difference for me, I wish I would've tried it sooner.

u/Ill-Sherbet-5844 — 3 days ago

Help mee

Hi guys, recently hopped on spire cus my derm prescribed it to me at like 50mg. I took it for like 5 days and noticed my forehead had texture and my right cheek was getting worse. He did tell me abt possibly purging but I’ve had clear skin my whole life, so I freaked out and stopped taking it after pill #5.

Now, the first pic is what my cheek currently looks like. I haven’t taken the pill for 3 days and the texture on my forehead went down but the cystic cheek stuff is still there (which I know won’t go away as quick).
I’m just frustrated and scared bc I only had like 2 cystic bumps that just wouldn’t leave since like February, and then I go to the derm for it, and I go on this app and see a girl w the same 2 spots and everyone was like are u stupid? Why would u go on it, and I was like bro…and I take the pills, and it gets way worse and now i literally have to go on it 😐😐😐😭😭😭😭

The second pic is my skin 2 weeks ago before taking it.
I had concealer on, but I did have like 2 cystic bumps hiding under there. Now I’m abt to like end it all. Help me plsssss omg do i go back to taking ts or like what 😭😭😭

u/Outrageous_Ball_4486 — 3 days ago

4 months…

I am 4 months on 150mg. (I’ve been on other doses prior to these last 4 months).
I am on MYA 28 birth control as well.
I also have premature ovarian failure, so, I’m not sure if that is why this is still happening.

I am STILL getting consistent breakouts and it always seems to come in threes. I’ll have maybe 2-3 days of no new acne but after that, I’ll get 3 or more pimples. It is quite frustrating.

I seen all these posts with people saying it took 2-3 months to be clear and my acne wasn’t even comparable to many others I’ve seen.

Has anyone had it take 4 or more months to get clear?

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u/Interesting_Cry_7374 — 3 days ago

How to get rid of all this excess weight?

I’ve put on a fair amount of weight since starting Spiro (25mg). Has anyone had a similar experience and if so, any success stories on losing the extra pounds or has it been a challenge to do so? I’ve always been super slim with a flat tummy and now I have a big old belly, wide ass hips and none of my pants fit anymore. welp!

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u/Ok_Dragonfruit5093 — 3 days ago

Accidental overdose

Last night I took 100mg and then later on I forgot I already took it and took another 100mg, i woke up drowsy with a headache and maculopapular rash, they're not itchy or painful tho just kinda warm?? other than that I feel fine, what should I do? 😭

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u/shutupimtalking1 — 3 days ago

should i give up on spiro?

have a derm appointment next week and I’ve been on spiro since September. started at 25mg, then 50mg, 100mg, and now 125mg, and I’m still breaking out.
my acne has never been super severe, but it’s been very persistent. I get around 2–3 pimples every few days, and they clear fairly fast but always leave behind scars/hyperpigmentation.
I’m also on a topical retinoid and azelaic acid, but I haven’t really seen much improvement in my skin texture or pigmentation from them either. my derm is suggesting accutane, but I’m honestly really nervous about the side effects. I asked about going up to 150mg of spiro first, but she said if I’m not improving on 125mg, 150mg probably won’t make a big difference.
it’s frustrating because my acne isn’t severe, and yet it feels so persistent compared to people with worse acne who seem to get results faster.
I honestly just feel a bit stuck because it feels like I’ve tried a lot and nothing fully works for me.

has anyone been in a similar situation? any advice would be appreciated

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u/Novel_Bite_3872 — 4 days ago

help me pleaseee

Hiii I’ve been taking Spiro since the 27th of January this year, started on 25mg once a day until about a month ago and then was upped to 50mg once a day. My skin still looks like this. My GP and I are convinced this is hormonal acne, which I’ve had since I was a teenager, I’m 22 now.
I drink a LOT of water, I wear SPF daily, I wash my face with Salicylic acid gently (which I’ve been doing for ages since I have so many closed comedones on my chin/around my mouth) I have cut down my dairy consumption, I don’t eat overly processed foods, I sleep 7-8 hours a night, I ALSO take doxycycline and have been for a couple months, but have been taking it on and off for years. Literally what could I be doing wrong. I feel like my skin is worse. I am feeling so defeated, I’m constantly breaking out ONLY on these areas, I have virtually no acne anywhere else on my face. I don’t have PCOS, but am prone to hair loss as well for some reason. Help me. Is it time to try accutane? Or am I just being impatient? I feel like I should be seeing more results by this stage. Help me pllleassee give me some encouragement I literally cry about this everyday and am in constant cystic acne pain 🥲 thank u love u xx

EDIT: thank you so so much to everyone who has replied !!! You are all amazing and I’m so grateful. I have been feeling really lonely and discouraged lately about my skin, but talking to you guys has really boosted my spirits and given me hope that I will find a solution. Much love ❤️

u/charcharjuno — 6 days ago

Alcohol on spiro

I had no idea that spiro enhances the effects of alcohol for some people. 😭 I’m on 100mg daily, my OBGYN said alcohol was ok. I am on lexapro so I only limit myself to a couple drinks, I’ve never gotten sick on it or even hungover. But omg I had a couple drinks last night and was violently ill not long after for two hours. It was AWFUL. I was so confused until I looked it up this morning and now I’m thinking spiro is the culprit (tho I’m sure the lexapro didn’t help either). I’ve never been sick like that, it got so bad I couldn’t stand and was considering the hospital lol.

Does this happen to anyone else and did it get better? I’ve been on it for a couple weeks and the diuretic side effects are just starting to subside.

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u/First-Year7315 — 5 days ago

period for 17 days

hey all!

i started my period may 1st and began taking 50 mg spiro each night starting may 4th. my periods have always been irregular because of how active i am with tennis and cheer, but my flow is usually light and lasts about 4-5 days. in fact, there were some months i just didn’t have one. however, as of today (May 17), I am still very much on my period and things haven’t gotten better. I’m soaking through super tampons in about 1.5 hours and cramping has only gotten worse over the last 2.5 weeks. i have debated going to see a doctor because i’m 99% certain its due to the spiro, but i’m starting to lose energy and feel completely out of it because of how much i’m bleeding. its also been interrupting my day to day life as im constantly bleeding through and having to either go home from school or go to the bathroom every hour. i’m also only 17, and a virgin, so pregnancy complications are off the table here. should i go see a doctor? its honestly starting to concern my family and i.

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u/No-Particular-606 — 4 days ago