u/Charupa-

A NEW IMMUNOSUPPRESSANT FOR KIDNEY RECIPIENTS

An experimental immunosuppressant drug being developed by Eledon Pharmaceuticals proved superior to the current standard treatment, according to data from a clinical trial, and looks to be a potential game-changer for kidney transplant patients.

Kidney recipients must take immunosuppressive drugs for ‌their lifetime to prevent organ rejection. The medications can affect both long-term graft survival and how patients feel and function in their daily lives.

While the current standard-of-care immunosuppressant – tacrolimus, in use since the 1990s – basically affects the entire immune system, the Eledon drug, tegoprubart, selectively blocks the activation of specific immune cells in the so-called CD40L pathway.

In a long-term follow-up study of kidney transplant patients who participated in a 12-month mid-stage trial, those treated with tegoprubart had superior kidney function from one month onward compared with patients treated with tacrolimus, researchers reported at the American Transplant Congress in Boston.

Patients treated with tegoprubart had no graft loss and no biopsy-proven acute rejection episodes after the first six months post-transplant, compared with roughly 64% in the tacrolimus group.

Side effects were less common with tegoprubart as well. Just 2% of those who got the Eledon drug experienced headache or acute kidney injury ⁠versus 12% and 6% for tacrolimus, respectively. None of the patients taking the new drug had extremity pain, or falls or loss of balance, compared with 10% and 6% for the standard of care.

“For kidney transplant recipients, success is measured not only by preventing rejection, but by preserving kidney function and maintaining quality of life over the long term,” study leader Dr. Andrew Adams of the University of Minnesota said in a statement.

Eledon has said it plans to conduct a late-stage trial of tegoprubart in kidney recipients later this year.
In a separate presentation at the meeting, Dr. Nicole Wojcik from the University of Chicago reported on a pilot study in which tegoprubart was well-tolerated and effective in patients with diabetes undergoing pancreatic islet cell transplantation.

South Carolina's unemployment rate fell for a third straight month in May to 4.6%. Other states reporting declines in unemployment included Delaware, Massachusetts, Ohio, Rhode Island and South Dakota.

South Carolina's unemployment rate fell to 4.6% in May as the number of employed residents increased by nearly 10,000, according to the South Carolina Department of Employment and Workforce (DEW). The decrease marks the third consecutive month of declining unemployment in the state.

The agency also reported that the state's labor force grew by nearly 78,500 people over the past year, pushing the state's labor force participation rate to 59% — the highest level in a decade.

Most of South Carolina's metropolitan areas continued to see year-over-year workforce growth. The Myrtle Beach area led the state in workforce gains, followed by Hilton Head Island and Greenville.

Nationally, the unemployment rate remained unchanged at 4.3% in May. Other states reporting declines in unemployment included Delaware, Massachusetts, Ohio, Rhode Island and South Dakota.

Additional information about the May employment report is available here.

I’m in Murrells Inlet, so maybe as far as Pawleys Island since I go that way often. Not NMB.

I tried to combine a couple filters into one and it seems to not be working as expected. Can anyone tell me how to fix what I’m trying to do here?

# Basic rule filtering users with <5 subreddit karma and CQS scores of "lowest"
type: submission
author: 
    combined_subreddit_karma: "< 5" 
    contributor_quality: "< low"
action: filter 
action_reason: "Lowest CQS"
message_subject: "Your post has been queued for /r/{{subreddit}}"
message: "Your post has been queued for moderator review due to your low Contributor Quality Score or subreddit karma: {{permalink}}. It will typically be reviewed and approved/rejected within 24 hours."

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Gas Prices in South Carolina are continuing to fall this week, dropping 17.4 cents as of Monday, bringing relief despite warnings from officials that things are far from settled. 

"Average gasoline prices declined in nearly every state over the last week, while all 50 states saw average diesel prices move lower," said Patrick De Haan, head of petroleum analysis at GasBuddy. "However, the outlook is far from settled." 

The new average price of gas in South Carolina as of Monday is $3.44 per gallon according to GasBuddy's survey of 3,028 stations in South Carolina. That recorded average is 64.8 cents per gallon lower than a month ago and approximately 58.7 cents per gallon higher than a year ago.

According to GasBuddy Price reports, the cheapest station in South Carolina was priced at $3.07 per gallon Sunday, while the most expensive was $4.37 per gallon, a whopping difference of $1.30 per gallon.

Excerpt:

• 33 percent decline in drug overdose deaths, better than the national average of 26 percent;
• 39 percent drop in opioid overdose deaths, the seventh largest in the country, Goldsby said;
• 41 percent decrease in synthetic opioid overdose deaths, better than the national average of 36 percent;
• 33 percent fewer overdose deaths from cocaine;
• 37 percent drop in overdose deaths from other stimulants, the second-best decrease in the country.

These 10 SC counties spend the most money on OnlyFans in the state, report shows

In total, South Carolinians don’t spend too much money on subscriptions compared to many other states, ranking 43rd in the country. Still, some of SC’s cities spend some of the most money in the nation, according to a recent report from OnlyGuider, a search engine designed for the OnlyFans creator economy.

SC cities that spend the most on OnlyFans

South Carolinians spent $36 million on OnlyFans in 2025, spending $65,860 per 10,000 residents. These two cities spent a lot more than the state’s average:

Charleston

Last year, people in Charleston spent $2.7 million on OnlyFans, which is $193,004 per 10,000 residents. Out of all the nation’s cities, Charleston ranked 21st for its spending per capita.

Columbia

Last year, Columbia residents spent $1.7 million on OnlyFans, which is $130,035 per 10,000 residents. Columbia ranked 53rd for its spending per capita.

10 SC counties that spend the most on OnlyFans

These are the top 10 counties for OnlyFans spending and how much they spent per 10,000 residents in 2025, per the OnlyGuider report:

1. Charleston County: $96,249
2. Clarendon County: $87,253
3. Lee County: $83,725
4. Barnwell County: $72,621
5. Anderson County: $71,724
6. Fairfield County: $71,547
7. Dillon County: $71,456
8. Lexington County: $70,583
9. Chesterfield County: $70,184
10. Pickens County: $70,079

The gas tracker reported the average price for a gallon of regular gasoline in South Carolina fell 3.6 cents, bringing the statewide average to $3.62 per gallon.

Prices are now 53.5 cents lower than they were a month ago but remain 78.5 cents higher than this time last year.

Nationally, gas prices also declined, dropping 9.3 cents over the past week to an average of $3.99 per gallon. That marks a decrease of 52.4 cents from a month ago, though GasBuddy says prices are still up 91.1 cents compared to a year ago.

Diesel prices saw a steeper drop, falling 11.7 cents nationwide to an average of $5.18 per gallon.

GasBuddy analysts say falling oil prices are helping drive the recent declines.

“Average gasoline prices fell in 47 states over the last week, with the national average dropping below $4 per gallon late Sunday for the first time since mid-April,” said Patrick De Haan, head of petroleum analysis at GasBuddy.

De Haan said the drop comes as oil markets react to reports of a potential agreement between the United States and Iran, which could increase global supply.

He added the outlook will depend on continued stability in global oil flows, particularly through key shipping routes.