



Found an interesting Nature report on how magic mushrooms (psilocybin) affects the human brain!
- This study found that psilocybin causes different brain regions to stop communicating in their normal way. The effect was so strong that the brain activity pattern of the same person on psilocybin became as if we are comparing two completely different people.
- People who had the strongest psychedelic experiences, showed the biggest changes in brain connectivity.
- Even after the drug effects were gone, the connection between the anterior hippocampus (memory/self-related region), and the Default Mode Network (DMN) remained reduced for weeks. Why this matters? Overactive DMN connections are correlated to depression. This explains the long-lasting antidepressant effects of psilocybin.
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Note: I don’t consume any magic mushrooms or any drugs. It’s simply an amazing study on how these alkaloids (tiny plants of mushrooms) impact communication between our neuronal connections. The findings really amazed me.
Reference: https://www.nature.com/articles/s41586-024-07624-5