u/Total-Pickle-1346

I’m 41 and just tested positive. This is my 5th pregnancy during the past two years. The previous four pregnancies ended in early miscarriages, TFMR at 18 weeks due to chromosomal abnormality and a MMC at week 11. All conceived unassisted.

I have two children that I had in my mid/late 30s, last one at 38. Also had two miscarriages between them.

Anyone 40+ with several miscarriages that went on to have a successful pregnancy? ❤️

I need your advice, support and honest opinions.

A little over a year ago I terminated a much wanted pregnancy due to a grey diagnosis, XXY. It was a short window of time for me to decide (thereafter I could not legally terminate in my country) and I forced myself to the decision. I felt numb at the time.

Since then it has become clear to me that I did the wrong thing. My boy would have been fine and he should have been here. I get more and more sad everyday. To add to this, I have not managed to conceive again since the TFMR. Only one early miscarriage and one MMC. This probably adds to my sorrow.

I don’t really have anyone to talk to. My husband is over this and think I should be too.

I had my egg retrieval yesterday. 41.5 with amh 0.5. Protocol was Letrozole day 1-5 and 225 iu menopur. Triggered on day 9 with double trigger.

Retrieved 9, but only 3 were mature. Today I got the message that 3/3 fertilized normally.

Any success stories with only 3 fertilised? 🙏

I had my egg retrieval yesterday. 41.5 with amh 0.5. Protocol was Letrozole day 1-5 and 225 iu menopur. Triggered on day 9 with double trigger.

Retrieved 9, but only 3 were mature. Today I got the message that 3/3 fertilized normally.

Any success stories with only 3 fertilised? 🙏

41 years. AFC 5. Baseline ultrasound today showed 5 follicles. Starting stims tonight. Any success stories with such low AFC? 🤞

I have two daughters and have been trying to conceive my third for almost two years without success. I have now realized I have to turn to donor eggs if I want another. We would use my husbands sperm so they would be half siblings.

Has anyone done this with prior genetic children and how was the experience?

Jag börjar med rapamycininjicering för min nästa IVF-cykel. Min IVF-läkare ville inte skriva ut det till mig, så jag fick det genom en läkare som specialiserar sig på livslängd.

Jag tänker mig att ta 5 mg en gång i veckan i 6-8 veckor innan min nästa ägguttagning.

Är det någon som har erfarenhet av rapamycin?

Jag försöker naturligt under sommaren, kommer det att stoppa min ägglossning? Finns det några biverkningar? Slutar folk eller fortsätter de under stimuleringar?

Im starting rapamycin priming for my next ivf cycle. My ivf doctor wouldn’t prescribe it to me so I got it through a longevity dr.

I’m thinking of doing 5 mg once per week for 6-8 weeks before my next retrieval.

Has anyone experience of rapamycin?

I’m trying naturally during the summer, will it stop my ovulation? Any side effects? Do people stop or continue though stims?

Im 41 and trying to conceive my third child. Amh 0.5.

Two first children conceived unassisted when I was 33 and 37.

Started trying unassisted at 39.75. Pregnant on first try but miscarried at 8 weeks. Pregnant again right after turning 40 but sadly had a TFMR due to chromosomal abnormality at 17 weeks.

After the TFMR my cycles where very long and I couldn’t get pregnant. Turned to ivf when I was 40.75. First round on high dosage and estrogen priming only yielded 5 eggs, 3 fertilized but no blasts. We went abroad for the cycle to pgt test but since we had 0 blast that didn’t happen.

In changed clinics and did a round in my home country right before turning 41. High doses of stims. 8 eggs but only one fertilized. Transferred a day 3 embryo but no pregnancy.

The next cycle I conceived unassisted. MMC week 10 after great beta and heartbeat week 8.

Last cycle I tried a medicated timed intercourse cycle with Letrozole and 75 iu menopur for 6 days. Chemical pregnancy and just started bleeding.

My doctor has suggested a new ivf cycle with milder stimulations (Letrozole and 225 iu menopur). I’m also in contract with another highly reputable clinic who says 450 iu menopur is what they would suggest. I’m also in contact with a clinic abroad who offer donor eggs with photos of the egg donors as children. I have found two donors that resembles me and my other children a lot.

What should I do?

I’m 41 with very bad egg quality. I have low amh and get 4-8 eggs per cycle but only 1 egg fertilized even with icsi, zymot and calcium ionophore.

I take all the supplements, do acupuncture and red light therapy. My husband also takes supplements but the problem seem to be me.

I just seem to have a lot worse egg quality than average. Statistically I should still have some euploid eggs though.

Has anyone been able to turn very bad egg quality around? Is it a matter of just keep trying or look into donor eggs?

I’m gearing up for my third ivf cycle.

I’m 41 with poor egg quality and DOR. I get pregnant naturally within a few cycles but miscarry due to chromosomal abnormalities. Sperm is normal.

First cycle: traditional IVF. 5 eggs retrieved, 3 mature, 3 fertilized. No blasts.

Second cycle: icsi with zymot and calcium ionophore. 8 eggs retrieved, 8 mature but only 1 fertilized. We transferred that as a 3 day embryo but it failed.

Should I do my third cycle with icsi or natural ivf? My clinic recommends icsi since that is what ”most patients do” but perhaps my old eggs don’t like icsi?

I’m gearing up for my third ivf cycle.

I’m 41 with poor egg quality and DOR. I get pregnant naturally within a few cycles but miscarry due to chromosomal abnormalities. Sperm is normal.

First cycle: traditional IVF. 5 eggs retrieved, 3 mature, 3 fertilized. No blasts.

Second cycle: icsi with zymot and calcium ionophore. 8 eggs retrieved, 8 mature but only 1 fertilized. We transferred that as a 3 day embryo but it failed.

Should I do my third cycle with icsi or natural ivf? My clinic recommends icsi since that is what ”most patients do” but perhaps my old eggs don’t like icsi?