r/Ureaplasma

I am here to share my experience, in case anyone else needs this information in the future. This will be long post, so I apologize in advance. I urge the moderators not to delete.

I am currently dealing with my third Ureaplasma infection. This one's symptoms arose about a month after a colonoscopy procedure. By now, I know how to listen to my body and know what it feels like when an infection is coming on. I have had the same partner since my last infection, and we were both cleared after the last, I even had several tests done to make sure I was negative, as I deal with chronic pelvic pain syndrome ever since my very first infection, so sometimes (as someone with health anxiety), I have gotten re-tested to confirm the symptoms were just residual.

Let's back up to May of 2025 - I had my gallbladder surgically removed. A few weeks later, I started having symptoms went and got a test done, and sure enough, an infection was present. Both my partner and I were treated, and hadn't had any positives again, until now, after this recent colonoscopy procedure where I went under sedation, and it was also incredibly stressful on my body as I WOKE UP during (I won't go into detail) and it was traumatizing to sum it up.

My first ever infection was also after my very first surgical procedure, back in 2023. I had a bilateral salpingectomy, and about a month later, I started experiencing pelvic and abdominal pain, and it took SEVEN months to get a diagnosis, which, by the way, the whole reason I figured out what was wrong with me, was through my own extensive research, and this subreddit, which I am incredibly thankful for. I had to request the test from my OBGYN and they stated to me "I seriously doubt it's that, but sure, we can test you". Sure enough, I was right, and thank goodness I found this info on my own. That is why I struggle with chronic pelvic pain now, because that infection was sitting there for that long. I have gone through several phases of pelvic floor therapy in the last few years, and do my own at home stuff to help manage it now due to finances.

My whole point of this, is to let you know, that I am proof that this bacteria can literally just overgrow when your body goes through something incredibly stressful - like, for example, surgery, once it has been introduced into your body. I am not saying it wasn't originally passed to me sexually, but after these instances, how am I supposed to know? I know there's not a whole lot of info out there about it, which is incredibly frustrating. I am now super anxious to ever have a surgical procedure again, and will likely have to ask for prophylaxis beforehand to prevent it. The amount of antibiotics I've taken in the last few years for these infections have not only ruined my vaginal flora (which was just starting to get slightly better), but I was also diagnosed with reactive gastropathy (stomach injury) last year, and I am almost certain that the antibiotics caused this, as I can feel the current ones re-lapsing the pain in that area.

This has been a very long and stressful past few years for me. I hope this information can be useful for other people.

help- unusual symptoms but no bv, yeast or sti

i am getting continuous abnormal discharge, the consistency is mucus like and a pale yellow/ milky white colour, which depends from time to time. i know this sort of discharge can be normal but i know it’s unusual for me, as it is also accompanied by soreness at the vaginal opening, pain during intercourse, irritated urethra and feeling like i’m not emptying my bladder properly. i have been tested for bv, yeast and STIS. i’m feeling quite helpless at this point and don’t really know where to go from here. i’ve got a follow up appointment at the gp for a pelvic exam too

My husband and I have been trying to conceive for 14 cycles. After a few years of having the infection and testing for multiple STIS/STDS, but never being tested for ureaplasma. I finally received a test for it and tested positive. Two weeks of doxy (both of us) and I retested 1 month later and my test was negative. It took almost 5 months for me to feel completely pain free!! I finally got an HSG done, and found out I have a completely blocked tube. I’m so thankful one was open, but devastated that one is blocked. This could have been potentially avoided if ureaplasma was on an STI panel!! I’m just so sad and bummed out.

***pinned post didn’t answer my question**
i got 7 days of doxy and my doctor said i don’t need azithromycin, however when i went the first time to pick up my 1g of az the pharmacy gave me 6 pills. therefore, i have 4 500mg pills of az left. after i finish the doxy, should i just take 1g of az or how many of the should i take?

I’ve done 5 days of azi and got 14 days of doxy to be taken after. Any chance this will work?

F24, I have had ureaplasma for at least 2 years now (possibly longer) but was not tested for it until April of this year due to nobody believing that its a real STI. My doctor prescribed 7 days of doxycycline and that did not work so I was retested in May and prescribed azithromycin, the standard 2 pills for one day + 1 pill for the next three days. I’m still in burning agony and just retested today but she will prescribe me levofloxacin/levaquin if this test comes back positive which I expect it to because of the pain i’m in. I’m really scared about the possible permanent side effects and wondering if I should do something different? I asked about minocycline and she said that probably wouldn’t work on me because the doxycycline didnt work and I also have an Evvy test that says it detected tetracycline resistance. She prescribed me vaginal estrogen and referred me to a pelvic floor physical therapist. I am going to ask about an HSG next appointment just because given that my infection has lasted so long im worried about my fertility now. I don’t seem to have any PID symptoms though, but lately I’m feeling light period-like cramps after orgasms and wondering if that has to do with it.

TLDR any advice at all is appreciated but I’m specifically worried about side effects from levaquin. I’m not even sure it will work on me after already trying doxy and azithromycin

I also have 2 weeks worth of doxycycline she prescribed me that I didnt take yet because I asked for azithromycin instead, and I’m wondering if I should take that before the levaquin to help weaken the infection at all. I’m asking reddit cus I honestly don’t feel confident that the doctors in my office care or know anything about ureaplasma.

Do I need doxy too?

Next week will be 4 weeks since I finished my second dose of antibiotics but I still have green discharge. I’m scared and annoyed that the antibiotics might of not worked. Does anyone still have green discharge after they finished antibiotics? I took Fluconazole followed by azithromycin. at this point it’s like I’m waiting and counting the days until I can retest but if that didn’t work what will? :/

Hi everyone, I'm looking for some experiences from people who have treated Ureaplasma.

I started having recurrent UTIs after starting a new relationship. I had never had recurrent UTIs before, despite having previous partners. During the first few months with my current partner, we used condoms consistently and I had no issues. Once we stopped using condoms consistently, I developed 4 UTIs within about 8 months, several of which were culture-confirmed E. coli UTIs. I also get "phantom" symptoms in between, but test negative.

We've done a lot of investigating and ruled out other causes (normal imaging, no stones, etc.), and I recently tested positive for Ureaplasma urealyticum. My doctor wants both my partner and me to treat with doxycycline and azithromycin.

My questions are:

1. Did treating Ureaplasma help reduce or eliminate your recurrent UTIs/UTI-like symptoms?

2. Did both partners get treated, and did that make a difference?

3. I'm honestly very anxious about developing C. diff from antibiotics. For those who have taken doxycycline and azithromycin, was this a concern for you and how did you tolerate treatment?

I know everyone's situation is different, but I'd really appreciate hearing others' experiences. Thanks!

Hi all,

I’ve been struggling with UP for about two months now after repeated incorrect diagnoses as UTI (finally figured out it was ureaplasma about a month ago). I was treated with Doxycycline 2x a day for 7 days and abstained from sex during that time as well as a week after. Strangely, my boyfriend tested negative for ureaplasma (and anything else). I am still experiencing symptoms and actually feel like they have been more painful the last few days as well as my urine becoming cloudy now. My only symptom throughout all of this has been pain with urination and some pain with sex. I just got another urine test and it came back positive for leukocytes and blood, consistent with a UTI. I was told it’s too early to retest for the ureaplasma since I just finished my antibiotics about a week ago, but they prescribed me Macrobid for the seeming UTI. Has anyone else had experience with their ureaplasma causing a UTI? My doctor told me this is something that can happen sometimes but I am not seeing a specialist so wasn’t sure how common this actually is. Will retest for UP in 3 weeks if the macrobid doesn’t resolve my symptoms. Any advice appreciated, and sending love to all on this subreddit who are battling with this!!!

I did 4 TOC since mid February (I had ended 14 days of Doxy and the dose of Azithro in the guide) which all came back negative, had ongoing symptoms, tested positive for strep b, treated strep b, felt good for two weeks. Then starting to have symptoms or urea returned. I have been completely sexually inactive for over a year. My TOC came back positive for UP at 10.2 UFC… it was 10.8 UFC when I treated in January. Is there anything else I should try alongside second line treatment?

Hi all! I am finally caving and making a reddit post in the hopes someone can help me out.

Over the last two months I have been dealing with extreme vaginal pain and UTI symptoms. I have had every test and it’s been a rollercoaster - I first tested positive for BV took meds and symptoms came back, then I got a random confusing Trich positive (I’m pretty convinced this was a false positive - I have had the same partner for years and know neither of us cheated) and also positive for Mycoplasma Hominis and Ureaplasma Parvum. I did my research and was sure these were what was causing all my pain and discomfort! I took the Doxy and another round of Metronizadole and my pain totally went away until about 4 days later and everything came back.

I have been retested for all the plasmas and all negative but i’m still in SO much pain. Like constant vaginal burning and now UTI symptoms (pressure, frequent urge to pee). I was negative for everything else you can think of and was retested for BV yeast trich etc but no infections. My OBGYN also did an exam and wet mount and nothing pointing at infection.

I have read symptoms can remain after Ureaplasma infections - is this always the case? Any tips on relief? I am now trying hydrocortisone suppositories. Sorta feeling like my OBGYN is over me and is out of ideas but she isn’t recommending a Urogynecologist referral so I’m at a standstill. The pain is one thing but the personal anxiety and hurt it’s causing my relationship has been so awful.

After using Push Health online to get doxycycline and azithromycin for my partner, the doctor didn’t put instructions to start azithromycin after finishing doxycycline. The pharmacist told him to take them at the same time, so he’s already taken 2 azithromycin and 1 doxycycline. What now? I don’t know if he should save the other 3 tablets to take after he finishes doxycycline or just keep taking both together. Ugh!
Thanks

I and my partner tested positive for U. Urealyticum in January (I know she also tested positive for some form of ureaplasma, but not sure of the exact kind- for me it was U. Urealyticum). We both took antibiotics and both tested negative afterwards. Since then, we had unprotected sex once a few months ago, and had protected sex several times.

I now, just to be cautious, retested for ureaplasma. This time I was negative for U. Urealyticum, but postive for U. Parvum (there were four kinds of ureaplasma on the test, including mycoplasma, and I tested negative for three of them but postive for U. Parvum). I read that of Urealyticum and Parvum, Urealyticum is the one that causes more symptoms, and U. Parvum is more commonly found as part of the normal microbiome of the genital area. I am having no symptoms and haven't had any.

If this variation could be benign, I don't want to have to go through the whole process all over again of antibiotics, then retesting and waiting for the results. I've also read too much anti biotics can make things worse. Last time I took antibiotics I got a yeast infection as well.

Please let me know what's recommended.

Thanks!

I noticed my discharge started smelling different than usual (no other way to describe it) about a month ago. No other symptoms so didn't do anything about it. Then about ~6 days ago I started to have a lot of itching around my vulva. I was having on and off itching, pain, discomfort, and irritation. My discharge looked a little creamier/whiter than usual and has an odd smell to it. I can't pin-point what it smells like but I can just tell it doesn't smell normal for me. I went to the doctor and they did a vaginal swab and I just got my results back.

It shows I tested positive for Ureaplasma (>10,000 CFU and <1,000,000 CFU) and shows it was sensitive to all the antibiotics listed (Erythromycin, Levofloxacin, Moxifloxacin, Telithromycin, Tetracycline).

The vaginal culture result shows Candida albicans. It says it is sensitive to all the antifungals listed (Fluconazole, Voriconazole, Caspofungin, Micafungin, Flucytosine).

I have an appointment tomorrow with my doctor to go over my results. I want to be prepared and have an idea of what to expect. Can these both be treated at the same time or will it need to be one after the other? Will I need to be re-tested at some point? This is all new to me, so any advice is helpful! I currently live in Spain if that is helpful info.

I also have a partner who I have unprotected sex with, does he need to get treatment for either of these as well?
Thanks!