r/Ureaplasma

Hi guys,

I have been diagnosed with ureaplasma about 2 years ago after sleeping with some chick (only after that I found out that she smelled funny when she was sleeping). I was prescribed doxy and felt great for a couple of weeks. Of course infection would come back but somehow I tested negative although symptoms were persistent.

Last night I had pelvic pain, urgency and irritation but after taking 250 mg of azithromycin I felt MUCH better and immediately fell asleep and slept like a baby. I don't know if it's linked but now I have problems with my right knee and foot, I think I have inflammation.

I cannot take doxy since the last time I took it I had intracranial hypertension (thinking I might have developed it after taking 2-3 courses of doxy).

Are there any alternatives to doxy? Cause, if I understand correctly the treatment course is 2 weeks doxy + azythromicin.. I will take azythromicin for sure but is there any alternative to doxy? I still can't understand which one of these kills the bacteria and which one just stops it from reproducing.

My life has been hell for the past year so I hope I will beat it.

Thank you all!

Around 2 years ago I got BV for the first time. Boyfriend was new at the time and his ex reached out to let him know she had Mycoplasma & Ureaplasma. We both tested, he was negative for everything & I was positive for Ureaplasma & Mycoplasma.
The treatment cleared my symptoms but since he wasn’t treated I continued to have yeast & Bv the next 2 years. I am being treated for Ureaplasma right now and so is he. I am negative for Mycoplasma thankfully.

Okay here’s where I’m having issues: I have EXTREME dryness and some burning/redness. My actual vaginal walls feel loose too. No discharge anymore. I can’t have sex because of how dry I am. I got off hormonal Bc a few months ago because I was worried that was the issue, but being off hasn’t improved my condition.
I also can’t feel my clit and vaginal walls over the burning. I hadn’t realized that was what was causing the numbness but I’m pretty sure it is.

When I was on antibiotics for BV last month I felt almost normal again. I could self lubricate and the looseness I was having went away. Unfortunately my symptoms came back after I finished my round of antibiotics.

Hormones have been tested and they’re all normal.
I am at my wits end. I have spent thousands trying to find a solution. Have been to multiple obgyns but none of them have a solution. Both OBGYNS have said my pelvic floor feels normal. My boyfriend thinks I don’t desire him and this is causing serious issues in our relationship. I’m in constant agony.
Has anyone dealt with extreme dryness? Would this be Ureaplasma related? Allergies? Could BV & Yeast cause this extreme dryness?

Hello!

I‘m getting tested for ureaplasma and BV on Friday after some odd vaginal odor. Long story short, I think this might be the answer to my chronic vaginal issues over the years. Chronic yeast infections, etc.

I’m going to my PCP because my gynecologist didn’t have anything until October. I am seeing one of their nurse practitioners for the testing as that is who was available the soonest.

I intend on bringing the specific tests I want done and asking that my results be reviewed by my normal doctor and that he contact me before medication is prescribed.

1. How do I ensure I get a long enough course of treatment? If they prescribe 7 days of doxycycline do I insist on 14? If there’s no zithro included, do I insist on that or supplement my own with a site like Starfish?

I am recently married, but my husband and I have been together a total of ten years.

2. If I am positive, how do I go about getting adequate treatment for my husband? Do we ask his doctor? We do not go to the same PCP as his job has a clinic.

Any advice is appreciated. If I am positive like I anticipate I will be, explaining all of this to my husband will be stressful. Not because of any fear of infidelity, but just because I’m sure he’s never heard of it.

Thank you!

Hi everyone! I thought I would come on here and share a bit of positivity. This is a bit of a long story but hopefully it brings some hope.

About three years ago I started getting persistent BV/yeast infection-like symptoms and ovarian pain/tingles. Everything kept coming out negative so I would just use some boric acid and pray. It would come and go and doctors wrote it off as “hormones”. I was put on multiple rounds of different birth controls but nothing helped and I got used to the irritation.

Last year I began to experience the worst vaginal itching and irritation of my life. Then I began to have UTI after UTI. No antibiotics worked and they would cause me to have back and forth rounds of BV and yeast infections. Finally after 9 months of that, a new doctor (this was my fourth one) swabbed me for ureaplasma/mycoplasma and took a vaginal biopsy. A week later I found out I had lichenoid dermatitis and ureaplasma parvum! I was put on one week of doxycycline 100 mg BID and I was given Clobetasol ointment for the Dermatitis. 6 weeks go by and I knew I still had ureaplasma. I had a vaginal ultrasound and it came back normal but I did a UA and a swab again and I still had it. This time my partner was treated and I was treated for two weeks doxycycline 100mg BID. I was not given the option of azithromycin but I am allergic so I let it go.

After that round of antibiotics, I still felt off so I ordered my own Evvy test and turns out I had BV. Took metronidazole, took a preemptive fluconazole for any yeast infections and finally…. Relief. I still had residual irritation from the dermatitis but I have gotten it down to hydrocortisone cream once a week at night and I don’t think I’m gonna be needing it anymore!

I will say that throughout this, many doctors dismissed me. I was given multiple antihistamines saying it was an allergy. I had one doctor say I had interstitial cystitis. No one could given me an answer until 3 years of torture. I still am not 100 percent but my ureaplasma symptoms are entirely gone. I am also happy to say I have tested negative :). I did take probiotics throughout but now only take them three times a week as a maintenance dose.

Please feel free to ask me any questions. My presentation was a little “weird” for ureaplasma but I am just happy to be on the other side.

Hi all! There’s not a lot of information on mycoplasma Hominis so I’m posting here to get some clarity.

I was prescribed 2 weeks of doxycycline by my gynecologist and I am not sure if the treatment really worked. I know residual symptoms are common but I can tell the difference between residual symptoms and symptoms after when a treatment doesn’t work. (I’ve had UU in the past so I’ve had experience with both).

There are some studies that show mh is naturally resistant to macrolides such as z-pack & clarithomycin.

I’ve found some studies/posts that show success with clindamycin. I’m going to make an appointment with Sarah Weld (she’s been recommended on this subreddit) if you know anyone in NY who’s well versed for plasmas, please let me know.

I’ve been seeing neena agrawala who’s been very helpful but doesn’t seem to know a lot about the treatments for these strains. I would really appreciate any insight from the mods or people on here what treatment would be the best for mh? I’m going to ask for clindamycin next if this test comes out positive. I know moxi is also a recommended treatment for mh. I’m still waiting a couple of weeks to get tested because I don’t want to get a false positive or negative.

again, any insight could be helpful! I’ve been dealing with this for a while and it’s taking a toll on my mental health

Hello everyone. I was tested positive for ureaplasma in january 2026. Before that I had been constantly hooking up with someone who indulges in hookup culture, except he was the only one I was sleeping with and it wasn't reciprocated. This was from november '24 to december '25.

I had ONE uti and yeast infection during December’24/january of 2025. After that, I was okay.

Then, during november/september ‘25, when the repeated BV and yeast infections occurred. I've never had BV before. Up until then. I was treated, then it came back. Over and over again.

until I tested positive for ureaplasma in january 2026. i was treated for antibiotics for 7 days and then had BV after. that was also treated. I got a boyfriend in february that I had sex with after I was treated.

Since then, i've gotten std tested AGAIN in march ‘26 and i'm clean off of EVERYTHING. l've had a NEW partner and current boyfriend since february of 2026 and he also tested negative on everything even after having sex with me.

Febuaury-Current ‘26, I still always had an itch/irritation around the hood of my clitoris. I just left it alone, because I just kept coming back negative for BV, Yl, everything else.

But during june ‘26, , I tested positive for a UTI.

Then I had this horrible uncontrollable itch from the hood of the clitoris AGAIN. it's always there. around that skin. Near the hair area.

I was checked by the doctors everytime i went btw and had no lesions or blisters.

Then 3 weeks ago, i suspected BV and i was positive. Except after the antibiotics im experiencing pain/itchiness in the hood of the clitoris AGAIN. today it's just unbearable.

Another thing, AUGUST ‘26 after my BV medication my boyfriend and I had sex 5 days after the antibiotics and we HAD to stop due to the fact that I was BURNING!!! My vagina was literally BURNING!!! After me and my bf search things up, we see "vulvodanyia" as a possible answer, but i'm not too sure : (

I went to the doctors and they checked me down there and checked if YI and BV lingered/came back, but it didn't.

(My bf does not cheat on me, he's always with me if anyone is wondering or suspecting)

I'm just so sad and I don't know what's wrong with me or if i'll ever go back to normal.

Please help me on what I should do going forward, or educate me on things I should do.

Hi,

In 2016 ureaplasma positive - took antibiotic
In 2020 ureaplasma positive - took antibiotic
In 2022 ureaplasma positive - took doxycline for 10 days
In 2025 ureaplasma NEGATIVE

I tested positive for 6 years. Even though I took antibiotics, the Ureaplasma persisted for years. Now, I have been trying to get pregnant for 19 months and am categorized in unexplained infertility. I have had 1 failed IUI and am currently undergoing my 2nd IUI.
I asked my doctor if there is any chance I might have endometritis due to the Ureaplasma untreated and progressing to the uterus for so long. She told me she would have noticed it on the ultrasound. However, I still feel like I might have endometritis. Has anyone experienced something similar? Should I ask for an endometrial biopsy?

This is gonna be long , but if you care enough too read thank you !!

So in 2022 I had a one night stand and got ureaplasma my pee burned so so bad and then it stopped I was treated blah blah but I still had waves of burning nothing as severe as now but still did it was mainly like for a week or two a week before my period and then would go away fast forward 2024 it came back and started becoming almost full throttle and advanced everyday into 24/7 raw burning in 2024 I had another one night stand and tested positive again I got treated and tested negative for awhile fast forward now I'm in a long term relationship and tested positive again he took a week doxy and 1g azithro and I took 14days doxy 1g azithro I'm waiting on test of cure and I'm not fully done I'm 10 days into doxycycline and have no relief at all it's almost worse I am close too my period though but it's just like a burning feeling in entrance and deep period makes it so so much worse but I never have any relief at all ima tarting too think it's not ureaplasma and it's probably nerve damage from that nasty infection I really can't sleep and my life is just so shitty these days and I really can't live another year of this gyno say they never seen anyone like this uro says this is from endometriosis and family doctors say see gyno which I've seen 3-5 different ones I'm just so lost and don't know what too do

Im a male and Ive had reoccuring issues with yeast infections for YEARS with my partner. On my end, I had candida overgrowth which led to balanitis. Eventually we figured that this was the cause of her yeast infections.

Everytime we would have sex, it was like rolling the dice. If she were to feel the yeast infection symptoms she would race to medicate herself. She would go through that pain and discomfort for a day followed by us not having sex for a few days there after.... after a while this took a toll on our sex life.

As for me, i felt dry, if we had sex too long or rough id feel irritated and my penis skin would look irritated, i wasnt producing precum or natural lubrication, my semen production seem to have dropped by a lot as well. If I didnt masturbate or have sex for some time, i would feel better but she would still feel irritation at times and the yeast infection will still eventually still happen.

After her going back and forth with her gyno for some time she asked me to look into getting prescribed something to see if maybe I was the cause. I tried multiple routes with otc, nothing. Tried seeing doctors and theyll push topicals and not give me fluconazole.

Eventually we got flucanazole.

We tried 3 days 150mg of fluconazole treatment and nothing. We tried it at a diff occasion again and nothing. We gave up. We actually ended up breaking up.

Now that Im single I figured I can figure this out without possibility of infecting anyone or reinfecting myself. I suspect that when we tried flucanozole we didnt give each other enough time after the treatment to let our bodies get fully treated.

Anyways, during my research, I came across ureaplasma and everything began to click. Long story short, I did not test for it.. i simply just did the treatment. My logic was, if I have ureaplasma and get rid of it.. i can then attack the candida.

I did the following:

14 days 2x/day Doxy - 100mg

1 day Azitro. - 1.5g

3 days Flucan. - 200mg

1 day a week for 3 weeks Flucan. - 200mg

I did all this without taking any zinc or magnesium during that time. I also, started taking probiotics that were given to my ex girlfriend by her gyno. (I read somewhere that the man should get on the same probiotics as the woman so floras cam match) The probiotics that I take are Fairhaven Health - Isofresh Vaginal Probiotic. I also ate kimchi, drank kombucha, and anything that supports gut health.

I feel the best that i have felt in a long time. I am producing precum, natural lubrication, I am producing more cum at a more frequent level. I dont feel irritation on my skin or glands.

Things were so bad for so long that I was beginning to accept that maybe this was normal. I felt that maybe with age my libido was dropping? Or maybe my body is just not going to be the same again.

I feel like i got my sex life back.

Only thing Id need to do to prove it 100% would be to have sex with either my ex or a new partner and see if she will get reoccuring yeast infections again. However, during these years, masturbation was not how it used to be... i had similar symptoms (irritation, itchyness, inflammation etc) when i just masturbated or masturbated too much. Now I am not having this issue at ALL.

Please feel free to ask me any questions, if some parts are not clear.

UREAPLASMA PARVUM has ruined my mf life!!!!!!!!!! Me and my partner treated it and I got negative results, we didn’t wait to have unprotected sed before the test (I know) I got pregnant, baby had a heartbeat made it to 7w3d and boom! I miscarried.

Ureaplasma has ruined my fucking life. !!!!!!! I hate it!

So I was wondering if there is someone who cured Ureaplasma for good and never got it again? I just want to date and have a family in the future but I'm scared of sex now because of this bacteria:(

Hope to hear some successful stories.

My most recent partner and I both tested positive for ureaplasma, but I am wondering: did I give it to him or did he give it to me? My only symptom was a sore throat while he got VERY sick (fever, vomiting, fatigue, etc.) However, the day before I had sex with him, I had sex with another partner, and after testing positive just days later, I told the earlier partner and he got tested but was negative for everything, including ureaplasma. So how did I have sex with two people consecutively and only the latter got ureaplasma? I read that 80% of vaginas have "dormant" ureaplasma that can be "activated" in the right conditions??? Uh so did guy #2 just have the magic ureaplasma breeding ground on his dick or what? I am really confused on the origins of ureaplasma. I understand that it occurs naturally in healthy urinary and reproductive tracts but how come it only decided to flare up with me and this particular person? Also, if I gave it to him, causing him to get super sick, how come I only got a sore throat? He has told me he has a weak immune system so maybe that's it? And again, if I am the ureaplasma superspreader, why did I not transmit it to the guy I had sex with just a day before? BUT, if guy #2 gave me ureaplasma, 1. Why did he get super sick, and 2. How did he get it in the first place? I'm not really sure how ureaplasma behaves in male anatomy. Also, he had not had sex in over a year prior to having sex with me. Could we have both been carrying ureaplasma and our union was the straw that broke the camel's back?

Sorry for all the rambling. This all happened months ago and we have both had a week of doxycycline btw. The confusion about ureaplasma has just been keeping me up at night LOL

Hi everyone, so about 2 years ago, I had mycoplasma and it was the worst thing in the world. I tried everything and what got rid of it was minoxycline, but I don’t think I would ever take it again because it made me extremely sick.

Anywho, I went to my gyno for a check up and I ended up tested by positive for U. Urealyticum DNA. I was completely blind sided by this as I’ve been tested maybe 40 times since my mycoplasma situation, the last time I got tested for ureaplasma was back in February-March I believe, I got this result in June. I’ve had the same partner for about 2 years and he is negative as well, but when I got this results back my gyno implied that my partner had to be unfaithful, but idk. I genuinely was surprised because I always felt like a little uneasy but I assumed it was cause of consistent utis and actually when I was told that, I was starting to feel okay.

I’ve had a lot of uti problems since the mycoplasma negative result but I saw that ureaplasma isn’t only caused by sex, when I looked it up.

I took 2 weeks of doxycycline followed by the azi (2.5g I think in total). I haven’t gotten tested yet and it’s been over 3 weeks but I plan to.

Anywho, I’m not sure if I’m cured but nonetheless, I’m confused. Is this true about it being only sexually transmitted?

And if if not negative from the doxycycline and azi- what are the other options besides moxi(which I’m allergic to) and mino?

Is it worth it to do 21 days of doxy and azi?

Back story: I have tested positive for UU in the past, (treated with the doxycycline and moxi course). I am not sure if it failed or if i was reinfected, because after i felt much much better for a while.
But lo and behold symptoms return and i tested positive again.
This time i am treating with a week of twice daily 100mg doxy and followed by 1g azithro.
I am half way through the doxy and was feeling much much better, symptoms had really went completely away. But it’s like they are creeping back in.
My original symptoms:
green tinged discharge (no odor), unusual urine smell, sever internal vaginal itching, and sever pain and burning when peeing.
Symptoms that have returned:
Itch in the same place but not as severe, and some slight pain or burning AFTER i pee.

I would just like to know if this is normal, or if the treatment is failing. Just some advice because i am very discouraged. I have had ureaplasma for a long time with out realizing and its done some real damage. I had a laparoscopy which diagnosed me with the blocked fallopian tubes and scar tissue. I’m only 18. I want to knock this out for good and am determined.