u/Competitive_Travel16

This post describes a new artificial intelligence tool for biology. The name of this tool is Evolutionary Versatile Architect, or EVA. EVA is a foundation model that analyzes and designs RNA sequences. This model helps scientists make new RNA molecules for medical treatments.

Scientists trained EVA with a very large set of data. The training data contains 114 million complete RNA sequences from many different species. These sequences come from a new database with the name OpenRNA v1. EVA uses a Mixture-of-Experts system to process a maximum of 8,192 genetic tokens at the same time. This large capacity lets the model read long RNA molecules from the start to the end.

EVA operates in two different ways to help researchers. First, the model predicts the effects of genetic mutations. It examines the evolutionary history of RNA across different species to find harmful changes. If a mutation causes a disease, EVA can identify the problem without new laboratory tests. This function helps doctors find the causes of genetic conditions.

Second, EVA generates completely new RNA sequences. A user can command the model to make a sequence for a specific protein. The model writes the sequence and improves the structure to increase chemical stability. EVA can design many types of RNA. These types include circular RNA, transfer RNA, and CRISPR guide RNA.

The developers made EVA available to the public. You can download the model files and the software code from GitHub. Scientists can use this open software to start their research projects immediately. This tool will change how we engineer new genetic therapies.

repo: https://github.com/GENTEL-lab/EVA

website: https://evabio.net/