▲ 1.1k r/science

Retatrutide, a triple hormone receptor agonist, for treatment of obesity | TRIUMPH-1 phase 3 clinical trial results show average patient lost 30% of body weight at 104 weeks on highest dose

nejm.org
u/Schwettes — 16 days ago

Hollandale tirz losing effectiveness after cleaning fridge?

I almost hate to post this. My first vial of Hollandale trizepatide was perfect, just as strong as the Mounjarno I was using before. I used every drop which took almost 8 weeks. Now, I'm on my second vial of Hollandale and it just doesn't seem as strong. Last week I reorganized my fridge and I’m wondering if that affected it. It’s BUD is this week although I just started it last week. I ramped up the dose by 900% (from .01mg to .1mg, every two weeks) and maybe it's better, but I'm going to take the dose up even more. It just seems strange this happened the second I after switched it’s place and cleaned my fridge.

Have there been any studies on how much triz degrades in the left side of the fridge versus the right side?

reddit.com
u/Schwettes — 20 days ago

Which employers do and do not cover Wegovy for weight loss?

Hello! 👋 I come to you as a former Wegovy user, and current Zepbound user. I am creating a dashboard to track which employers do and do not cover GLP-1s for weight loss and I need your help to fill it out. I know this information is constantly changing, but as someone in the middle of a job hunt, it helps to know up front what a company does or doesn’t offer as part of its employee benefits, even if it may change. If you know of an employer that does or does not cover Wegovy, could you please complete the survey?

🗣️ Survey link > https://docs.google.com/forms/d/e/1FAIpQLSfS2dSLgn2MexQegccHxm4d6KuI4rpiZe8QJDFqWnY73Gsx1Q/viewform

The survey is completely anonymous and only takes a couple of minutes. I’d like to create a repository for the community as it’s really frustrating how inconsistent and inconvenient coverage is. If you are in the hunt for a new role and want to see what coverage looks like right now, check the tracker below!

📊 Full survey results + tracker >

https://docs.google.com/spreadsheets/d/1TqwXvwOe5t06sINthCGrRPLQXncB7XkL5LRLovZ9LHI/edit?usp=sharing

Edit: Fixed the broken link!

u/Schwettes — 28 days ago

Possible names for CagriSema according to Novo Nordisk trademark filings

I hope we’re getting close to Cagri approval but in the mean time, here are some possible names based off of what Novo has filed this year. Quite frankly, I think the names suck but I think Coureli and Wegovamy have the most promise.

u/Schwettes — 1 month ago
▲ 225 r/joinrift+1 crossposts

⚜️Boudreaux’s Recall - Big Easy patients not impacted

Hey y’all -

I just received word that Boudreaux’s initiated a recall for lot 226980 of TZ 20mg/Glycine 5mg/ ml injection solution (3ml) dispensed 7/27/26.

I don’t have any other information at this time, other than it is represented to me that it is a small number of vials and impacted a limited number of patients, none of which were ours. We are currently at a 1.4% usage rate amount patients for Boudreaux’s over the past 3 months, which is likely why we were able to get crossed off their list quickly for impacted patients.

Happy to answer any questions, but this is largely all the information I have at this time. May have more tomorrow evening.

Thanks y’all,
Dave

reddit.com
u/Schwettes — 1 month ago
▲ 1.7k r/science

Higher semaglutide dose is associated with lower neuropsychiatric event incidence independent of weight loss

nature.com
u/Schwettes — 1 month ago

Interesting article in the Boston Globe | “Don’t take GLP-1s? Be prepared to explain yourself.”

I knew this would happen. I could see it coming I’ve already seen it in my personal life. People with obesity who aren’t on GLP1s are now being pressured and shamed for why they aren’t doing so. And it’s breeding all kinds of resentment all around. I love talking about GLP1s and these medications are truly miraculous for me but I can totally see why someone might end up feeling this way, even if I disagree. Pulled a snippet from the article:

“Just ask Traci Finkel, 37, an executive assistant at Boston Children’s Hospital, who’s been dealing with pressure to lose weight since childhood, when her sister was taken bikini shopping while her outing was to Weight Watchers.

“It’s almost like people are in a cult,” she said of those using GLP-1s. “The drugs are \[messing\] with people’s minds. It reminds me a lot of the diet pills in the ‘80s. Just do this easy thing, and you don’t have to do anything else.”

Or Ashley L., 37, a bartender and server from Malden who knows she has weight to lose but who wants to do it naturally, and to say “\[expletive\] you” to the co-workers badgering her to take a weight-loss drug.

“The ladies I work with, they’ve all taken GLP-1s, and they’re like, ‘What are you waiting for — do you want to stay like that forever?’” she said, requesting that only her last initial be used for privacy reasons.

Heads up that the opinion writer does seem vaguely anti-GLP1 but I think it’s a fascinating article that’s capturing an important view point nonetheless.

https://www.bostonglobe.com/2026/08/31/lifestyle/ozempic-weight-shame-fat-phobia/

u/Schwettes — 1 month ago

How to develop personal style after and during drastic weight loss?

Like many others, I’m on a GLP1. That means I have lost a ton of weight but still have a long way to go to my final goal. Now that that’s out of the way, I have no idea how to dress or style my body. I have had obesity my entire life and so I never dressed the way I wanted or in a way that looked stylish. I had to pick from what was available for my size. That meant that at 13, I was shopping with mom in Macys and wearing Charter Club instead of wearing juniors clothes. I’ve always dressed either really matronly and churchy or in stretchy athletic wear. Petite plus options are hard enough to find, and petite plus felt impossible.

Now that I’m in my mid 20s and on the cusp of straight sizing (I’m approximately a petite sz 16 who is working toward being a sz 2-4, so still a long way to go), I want to start developing a new wardrobe that is actually stylish, while also being mindful that my body is still changing so I don’t want to buy too much. How do I do I manage both? After a lifetime of Charter Club, which brands can I even try at my size? My inseam is no more than 30 inches.

I am pear shaped with a large bust. I’m interested in wearing heels to appear taller as well. Season wise, I think fall is probably my favorite fashion season.

reddit.com
u/Schwettes — 2 months ago

Started injecting water, still not losing any weight. Should I titrate?

I can’t afford GLPs, so after seeing many people say their trizepatide feels like water, I figured I should start injecting water to save money to get the same effect. But after 3 days, I have not lose any weight. Should I titrate or just start split dosing?

reddit.com
u/Schwettes — 2 months ago
▲ 124 r/Zepbound

“GLP-1s are just a band-aid.” My response: What’s wrong with using a band-aid?

I’ve been seeing a shift in my TikTok FYP and I’m seeing more and more people quitting GLP1s and they say that it’s because GLP1s are just a “band-aid” and they want to treat the “root cause.” Well, band-aids serve an important function! They cover up wounds, but in doing so they help wounds recover faster, they’re flexible and move with your body, and they provide added comfort so your wounds don’t get hurt.

GLP1s help people lose more weight faster, there’s variety in the kinds of GLP1s and their dosing, and lastly, they make weight loss a lot more comfortable by reducing food noise and increasing satiety. I don’t see anything wrong with GLP1s being a “band-aid.” Band-aid’s serve a specific purpose and they are very good at their jobs when used appropriately. What about you?

reddit.com
u/Schwettes — 2 months ago
🔥 Hot ▲ 9.0k r/science

Study finds GLP1 semaglutide reduced systemic inflammation within weeks, before substantial weight loss, and lowered MACE (major adverse cardiovascular events) risk even without weight loss

ahajournals.org
u/Schwettes — 2 months ago

What information or evidence do you cite when people question you on the safety and efficacy of compounded tirzepatide?

I saw a post on the brand name sub where people were discussing why they choose self pay for brand instead of compounded tirz. A lot of people were concerned about the lack of regulation, batch testing, and transparency. I only recently stopped drinking the Lilly kool aid but want to know more from people who have studied this for a long time.

reddit.com
u/Schwettes — 2 months ago
▲ 4 r/Advice

How do I offer to pay for my friend’s vacation without making it awkward?

I (F25) have a trip planned to see a concert for a group we enjoy and I want my best friend (F25) to go. She’s works full time but is in grad school so money is really tight for her. We’ve discussed it and she has kind of been reluctant to commit to going and I’m like 90% sure it’s because of money. I was talking to my parents about it and they’re willing to pay for her to go (flight + hotel + ticket) but I don’t want to make it awkward for her.

How do I broach this and offer it without putting any pressure on her or making her feel small by offering to pay? Probably looking at about a total value of $1000.

reddit.com
u/Schwettes — 2 months ago
▲ 159 r/PMOSonGLP+1 crossposts

Stalled on Zepbound? Eli Lilly to allow more patients to apply for compassionate use of retatrutide

“For a limited number of patients who meet specific medical criteria and cannot enroll in a clinical trial, we believe it is medically appropriate to make authentic retatrutide available before FDA approval, consistent with FDA’s guidance,” a Lilly spokesperson told STAT.

https://www.statnews.com/2026/08/03/eli-lilly-retatrutide-mystery-patient-doctors-seek-same-access-their-patients/

Also somewhat encouraging to read the article and to learn that friend of the sub, Dr. Spencer Nadolsky, was able to have a patient preliminarily qualify.

u/Schwettes — 2 months ago

How involved is your doctor with your Zepbound journey?

I’d like to know what’s going on with other people. My doctor is very hands off. I got the script and that’s pretty much it. I had to teach him how to send a prescription to LillyDirect and while he prescribed it for me because I wanted to transition from telehealth, but I have received no actual instruction or counseling from him. I’m fine with that. I haven’t had any concerning side effects and there are tons of online resources. But he didn’t teach me anything about goal setting, he didn’t teach me how to do anything really.

But it looks like some people do have more custom, personal medical care with doctors to manage dosing and frequency and I wonder what that experience is like. It seems like some people have super hands-on doctors who manage their care closely and either deny or force dose changes. I don’t get the sense my provider knows that much about these medications at all and wouldn’t be a great resource for education.

reddit.com
u/Schwettes — 3 months ago

At what point are we taking new ID and passport photos?

I’m down almost 50lbs with tirzepatide since March. My passport is about to expire and I do generally like to travel internationally a few times per year, but I would like to lose another 90-100lbs. I don’t think it makes sense to get a new passport today when I have that much left to lose, but I’m wondering what everyone’s else is doing.

reddit.com
u/Schwettes — 3 months ago
▲ 191 r/Zepbound

News: Eli Lilly pushing retatrutide approval application back. Lilly plans to submit the drug as a biologic in Q1 2027.

Providing an update for the people who may have stalled at 15mg on Zepbound or are seeking alternative treatments for obesity treatment. If you’re looking to switch, you’ll have to wait a little longer. Eli Lilly released some new data on their phase 3 obesity trials and some important information on what the future looks like for retatrutide.

“In TRIUMPH-2, adults with obesity or overweight and type 2 diabetes, a population with increased difficulties losing weight, lost up to an average of 49.6 lbs (20.8%) at 80 weeks. In TRIUMPH-3, adults with severe obesity and established cardiovascular disease, with or without type 2 diabetes, lost up to an average of 55.8 lbs (22.6%) at 80 weeks
>Lilly plans to submit a Biologics License Application (BLA) for retatrutide to FDA in Q1 2027”

https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-successful-two-additional

“The pharmaceutical giant previously said it would submit an application as early as this year for the weekly injection, retatrutide, which works differently and appears to be more effective than existing shots and pills. In a statement to CNBC, Lilly said it needs more time to gather and verify the manufacturing and quality-control data required by regulators before it can seek approval.”

https://www.cnbc.com/2026/07/23/eli-lilly-will-file-for-approval-of-retatrutide-obesity-drug-in-2027.html

u/Schwettes — 3 months ago

Is there an antidiet way to encourage someone to use a GLP1?

I have a close relative who I think would really benefit from a GLP1. He is in his late 30s has a diagnosis of Class III obesity and unfortunately, he has developed high cholesterol and type 2 diabetes. He does not take the Metformin or statins prescribed because he feels as though it irritates his stomach. Without shaming any particular food group, his diet unfortunately is not filled with particularly nutrient dense foods that could improve his cholesterol or blood sugar. As a result, he is living with untreated diabetes and untreated high cholesterol and his weight is continuing to go up.

I don’t want to overstep my boundaries or take on the responsibility for his health. And I also know most of us have had uncomfortable and hurtful conversations with loved ones about our weight, but I am *really* scared for him and I don’t know if or how to help.

Edit: I have only included his food to contextualize so I could get better advice. It isn’t to shame his choices, but rather to explain that his situation is not being managed with non-medical interventions like changes to nutrition and lifestyle.

reddit.com
u/Schwettes — 3 months ago

How to track progress without resorting to too much body checking?

Also CW: IWL

I have been faithfully using a scale to measure progress almost every day, but scales aren’t perfect. But in moments when the scale hasn’t moved in accordance with how much I’m eating or moving, I found helpful to use a tape measure and a really nice, but tight pair of jeans to track progress. Well, I think it’s worked to help me track my weight loss, but now I’m wondering if I’ve let it snowball out of control.

I find myself trying on the jeans 2-3x per week and taking a progress pictures to see if I’m getting smaller. I’m wondering if I’ve let this snowball a bit. Ironically, I’ve become so neutral on the scale that it doesn’t really phase me much now, but instead I’m more concerned with tracking size instead of weight.

It doesn’t help that a few weeks, someone yelled at me and called me fat because I asked them to stop smoking on the bus even though I’m 1/3 of the way to my goal. It’s like a reminder that I have so far to go even despite how far I’ve come.

reddit.com
u/Schwettes — 3 months ago