u/hey_simmran

I've been watching the pipeline for retatrutide and recently the first phase 3 results are seriously impressive. In the TRANSCEND-T2D-1 trial, the high-dose group (12 mg) lost an average of 36.6 pounds (16.8% of body weight) at 40 weeks. And here's the kicker: weight loss continued through the end of the treatment period with no plateau observed, meaning it might have kept going if the trial had lasted longer.

For comparison, tirzepatide's phase 3 trials showed about 15-20% weight loss over 72 weeks. Retatrutide is hitting those numbers in about half the time. The drug is still investigational and not yet FDA-approved, but if the full phase 3 data holds, it's going to be a major contender.

So I've been working through this one piece for about two weeks now and honestly thought I'd pretty much nailed it down. I've been recording my practice sessions the whole time just to track progress, wasn't really expecting to find anything wild in them.

Then last week I sat down and actually transcribed one of my recordings back into notation, just to see what I'd actually played versus what was on the page. And that's when I caught it, a half step wrong note I'd been hitting in the exact same bar every single run through. The second I saw it written out I could hear it clear as day, but somehow it had slipped past me on every listen back before that.

And this got me thinking way beyond just fixing the one note. There's a real gap between what I think I'm playing and what I'm actually playing, and there's no way I would've caught this from just listening. Seeing it on paper made it impossible to ignore anymore. Anyone else done something like this?

The returns automation pitch is compelling on paper. High volume, repetitive case types, policy-driven resolutions that could theoretically happen without a human reviewing each one. The deployed reality across most tools marketed as returns management ai is that the automation layer is thin: intake is digital, but the actual resolution, reviewing the case, applying policy, deciding the outcome, still requires a human.
That's not nothing.
Organizing intake online has efficiency value and it beats email forms. But it's not what ""AI automation"" implies, and teams find this out quickly when the human review queue is the same length as before and the only visible change is that customers submitted their returns through a chatbot instead of a contact form.
Genuine returns automation handles the decision layer: applying policy rules to specific case types, accessing order and fulfillment data to validate claims, resolving straightforward cases without human review. Most tools in the market are positioned as if they do this while actually operating at the intake level only.

Got tired of every "cheapest company swag store for startups" article being sponsored content for the most expensive vendors. So I built the actual spreadsheet across six vendors for our 18 person seed-stage team, $4k projected annual budget. Here's the breakdown nobody is publishing because it doesn't make anyone look special. Sendoso. Comes in around $9k effective annual cost when you include the platform fee, built for companies 10x our size, ruled out fast. SwagUp. Lands at roughly $7,200 annual including the platform fee, decent product overall but the fee eats most of our actual gifting budget. Printful. Comes in around $3,200 effective annual if we build our own storefront, requires real engineering time we don't have right now. Swaggy Shop. Runs $4,100 effective annual at our projected volume, no platform fee, markup-only on items that actually ship. Snappy. Lands at roughly $5,400 annual including their smaller platform fee, polished recipient UX, narrower catalog for general use. Custom Ink. Bulk vendor that works for one-off batches, would be cheaper for a single order but not really a store for ongoing use. The honest answer is that "cheapest" depends entirely on volume. Below 100 annual gifts the markup-only platforms win by a wide margin. Above 500 platform-fee vendors start to make sense. At seed-stage your volume almost never justifies the platform fee, which is exactly the math the sponsored content avoids running.

I've always been a little nervous about the black box warning for pancreatitis, but a large real-world study presented at DDW 2026 was pretty reassuring. In a cohort of thousands of patients with type 2 diabetes and obesity, researchers found no increase in recurrent pancreatitis among those who continued GLP-1 therapy. Another analysis found no evidence that these drugs increased the risk of developing acute pancreatitis, with a trend toward a lower risk. More data always helps when discussing risks with a nervous provider.

I teach high school biology and chemistry, and I've watched students cycle through every flashcard app on the market trying to find one that helps them retain. Here are the six I'd recommend, ranked roughly by which ones students stick with longest.

Remnote works for students who already take digital notes, the notes they write become flashcards they review later, no separate card making session. It handles image occlusion natively, which is helpful for biology and chem labelled diagrams.

Anki still my recommendation for serious students who can handle the setup learning curve. spaced repetition is unmatched, but onboarding is rough for anyone under 16 who isn't already tech inclined.

Quizlet is something kids love bc of the games and shared decks. fine for vocab style content, weak for anything diagram heavy or where retention beyond a week matters.

brainscape: confidence rating system genuinely works well for self aware students, but the paywall hits before the value does for most teenagers.

Cram .com: dated interface but the print options are useful for students who study better on paper. underrated for that specific use case.

tinycards: defunct now technically, but mentioning it bc some duolingo adjacent options still work for younger students who want gamification without quizlet's chaos.

If a student asked me ""just give me one,"" I'd say remnote, with anki as the answer for the kid who's already shown they can stick with hard tools.

I’m trying to simplify things and focus on a few agents that actually move the needle for income, not just automate random tasks.

Right now I’m thinking in terms of roles, like:
- a lead gen / prospecting agent
- an outreach + follow-up agent
- maybe a content or distribution agent

But I’m not sure if that’s the right split or if i’m missing something more important. If your goal was purely to increase income, what 2-3 AI agents would you build or use?

Considering hiring a wedding planner but have no idea how to evaluate if someone is actually worth what they charge. From what ive seen online, day of coordination tends to start around $1,500 and full planning can go up to $8,000 or more which is a huge range, and I genuinely cant figure out what makes someone worth four times more than someone else beyond years of experience.

Where did you find yours and how did you decide they were the right fit?

I am a veteran dealing with TBI symptoms from deployment. The VA recently started covering hyperbaric therapy at certain facilities. My care coordinator suggested I try it.
The process through the VA has been slow with lots of paperwork and appointments before actually starting sessions. But coverage is approved which is huge because I could not afford this otherwise.
Curious if other veterans here are using this through VA benefits. How has your experience been with the VA program? Any tips for navigating the system?
Also looking for experiences from vets with TBI specifically. What kind of improvements did you see if any? Trying to have realistic expectations.

Before having a baby my routine had about eight steps and I thought I'd keep most of it. Kept three. Everything else got cut not because I made a deliberate decision but because I just stopped doing it and eventually accepted that wasn't coming back.

What stayed: a gentle cleanser I could use one-handed without thinking, a moisturizer with SPF for daytime, and something for the undereye area because the dark circles were the thing that actually bothered me when I looked in the mirror.

The non toxic piece became more important after having a baby than it ever was before. When you start thinking about what's on your hands before you pick up a newborn it changes how you evaluate everything in your routine pretty quickly.

The eye balm specifically, switched from something that needed a specific patting technique to a thicker balm I could just press on in ten seconds. Sometimes the ritual stuff is great but it wasn't compatible with where my life was.

The Life Alert brand carries decades of "help I've fallen" cultural baggage that makes a lot of active people dismiss the whole category before they look at what the current devices actually are. The form factor conversation has moved significantly from those oversized pendant TV commercials but that image is sticky in a way that is hard to shake.

For someone still working, still going places, still moving around publicly, the question isn't really about the monitoring service itself. It's about whether the device is something that actually gets worn every day versus something that sits on the nightstand because wearing it feels like a public declaration.

What form factors have people found that actually work for consistent daily wear without announcing anything?

Asking this group specifically because senior owners are usually the most clear eyed about what supplements really do versus what the bottle promises.

My shepherd mix Ranger is 10, has moderate hip stiffness, worst in the morning and after long naps, x rays last year showed early arthritis in both hips. The thing that pushed me to start a supplement in the first place was the bunny hop, both back legs moving together instead of alternating when he'd get going on a walk, I knew that gait change wasn't normal and the vet confirmed it the same week we did the x rays. Vet had me start a daily joint supplement and gave the standard cosequin recommendation. We did cosequin for 8 months and he was fine on it, not dramatic but steady, which I think is what it was supposed to do.

Recently found a brand called paws and whiskers, their hip and joint chew has a slightly heavier ingredient panel than cosequin with hyaluronic acid alongside the standard glucosamine and chondroitin, and their chondroitin and glucosamine doses look stronger per chew. Price is similar, possibly a touch less per chew. The kicker is the chews are smaller and softer which matters because Ranger lost a couple of teeth last fall and the cosequin chews have become a daily wrestling match.

If you've used paws and whiskers on a senior dog specifically, did you notice a real difference from cosequin or whatever you were on before. Also open to other newer brand suggestions if there's something better than paws and whiskers that I haven't surfaced yet. Trying to make an evidence based decision rather than chasing marketing.

Sharing because someone asked at the playground last week. Mom of one, 4yo, both parents work, brooklyn 1BR, evenings tight but predictable.

5:30 daycare pickup, 8 minute walk home. A snack on the walk buys some peace. 6:00 dinner together at the kitchen table that doubles as a desk that doubles as a craft station. 6:45 free play in the living room while the other parent does dishes in the same room because thats apartment life. 7:00 phonics time, 15 min on the couch. We rotate through reading.com for structured lessons, alphablocks on youtube once a week, and bob books from the library. Having options keeps her engaged without us needing more space. 7:15 bath in our one tiny bathroom. 7:45 stories in bed, three picture books chosen by her. No phonics in this slot, on purpose, because bedtime stories should not feel like drill time. 8:00 lights out around 8:15 once the negotiation is done.

The phonics piece is what other moms in the building ask me about. Rotating between options is what keeps her from getting bored before weve built any actual skill.

Edit: No idea why was it removed, here’s me trying again. Thanks!