u/aHumanRaisedByHumans

Contents

CLC-1 Inhibition Improves the Function of Neuromuscular Junctions in Aging Muscle

The Aging Immune System Disrupts Maintenance of Bone Tissue

Quantifying the Risk of Alzheimer's Disease Associated with High Levels of p-tau217 in Blood

Gut Microbiome Composition Correlates with Epigenetic Clock Results

Small Molecule GPR40 Agonism Restores Thymic Activity in Aged Mice

ZFP384 Inhibition Improves Microglial Function to Promote Greater Regeneration Following Stroke

Plant Mitochondria from the Diet Interact with Native Mitochondria to Improve Function

Mitochondrial Dysfunction in Parkinson's Disease is Complicated

TFAM and Mitochondrial Dysfunction in Aging

CMLase Enzyme Developed to Break Down CML Advanced Glycation Endproducts

How to Go About Measuring Health in Aging is its Own Sizable Debate

Reviewing Age-Related Changes in Microglia

A View of Aging Centered Around the Role of Karyopherins and Nuclear Transport

Senescent Cells Accumulate Lipid Droplets in the Aging Brain

SORLA Upregulation as a Possible Means to Treat Tauopathies

From AI:

While exercising in hot weather does raise your core temperature, a dry sauna creates a distinctly different stress profile on your body. The short answer is no, exercising in hot weather does not replicate all the benefits of a sauna session, nor does a sauna replace exercise. Instead, they trigger overlapping but distinct physiological responses.

How Sauna Stress differs from Exercise Heat Stress

During hard exercise in hot weather, your body faces competing physiological demands: your heart must pump blood to your working muscles to supply oxygen and fuel, while simultaneously pumping blood to your skin to dissipate heat. This creates intense metabolic strain, high oxygen consumption, and rapid depletion of energy stores. In a dry sauna, your body is completely at rest physically. Because your muscles are not working, your cardiovascular system can redirect up to 50–70% of your total cardiac output directly to the skin for cooling. Your heart rate rises—often reaching 100 to 150 beats per minute, mirroring moderate cardio—without the mechanical impact, muscle breakdown, or metabolic fatigue of exertion.

Unique Sauna Benefits You Don't Get from Intense Exercise

• Pure Parasympathetic Recovery: Hard exercise in heat triggers a massive surge of stress hormones (cortisol and epinephrine) to keep your muscles firing. Saunas, after the initial thermal shock, encourage a rapid shift toward the parasympathetic ("rest and digest") nervous system, promoting muscle relaxation, reduced tension, and lower systemic stress levels.
• Cardiovascular Conditioning Without Mechanical Stress: Saunas induce deep vasodilation (widening of blood vessels) and improve arterial flexibility entirely passively. For anyone dealing with joint pain, recovering from a tough workout, or managing an injury, the sauna delivers cardiorespiratory strain and vascular flushing without putting a single pound of force on joints or connective tissue.
• Selective Thermal Dose: In ambient high-heat conditions (like 170°F–200°F in a dry sauna), your core body temperature climbs rapidly in an environment of low humidity. Exercising hard in high heat usually forces you to stop due to central nervous system fatigue or exhaustion long before you achieve the hyperthermic threshold that a sauna allows you to comfortably sustain.

Unique Exercise Benefits You Can't Get from a Sauna

• Muscular and Metabolic Adaptations: Heat exposure burns very few calories compared to exertion. A sauna does not build muscle mass, increase bone density, improve insulin sensitivity in working tissue, or build mechanical strength.
• VO2 Max and Structural Heart Changes: While a sauna challenges your heart rate, intense exercise forces structural adaptations in the heart (such as increased stroke volume) and forces your mitochondria to grow and use oxygen more efficiently.

Overlapping Benefits

Both activities trigger Heat Shock Proteins (HSPs)—special molecular cellular repair mechanisms that protect proteins from misfolding, aid cell recovery, and support long-term cellular health. Both also expand blood plasma volume over time, which improves your overall endurance and tolerance to heat. Ultimately, hard exercise builds muscle, burns fuel, and builds physical capacity, while a sauna provides pure vascular work and cellular cleanup without adding muscular fatigue. Using them together—such as sitting in a sauna after a workout—tends to produce a synergistic effect on recovery and cardiovascular health.

My podiatrist told me to do a vinegar soak each night but I'm seeing conflicting information on rinsing it off or not. Like when the surface evaporates it will concentrate the acid there.

One successful post on here was a person who just did vinegar soaks and they rinsed with water every time just for the smell but maybe that was actually key in order to help properly.

I've been prescribed ciclopirox too and I wonder if it's less effective with the vinegar

Scientific article:

https://www.nature.com/articles/s41467-026-75141-2

Revel Pharmaceuticals, a spin out from SENS years ago. Also happy to see that Google's longevity research company Calico contributed to this research.

https://x.com/i/status/2075042006531985425

Reports from many that since there are dry areas on the salt lake now that it could contain toxic dust.

Also it's wild that it has gotten to this point. Flood it NOW please. Let the alfalfa die. Drain Utah lake a little. This is nuts.

https://www.instagram.com/reel/DajtXT6NKKl

Edit: some do pick it up:

The Utah Division of Air Quality (DAQ) Map: The state government uses regulatory-grade Federal Reference Method (FRM) monitors. Unlike consumer lasers, these instruments physically pull air through a filter and weigh the actual mass of the dust. They capture 100% of blowing PM10 lake dust.

https://air.utah.gov/currentconditions.php

Anything that runs Wear OS please! All the Pixel watches, Samsung watches!