4 weeks on semaglutide with almost no effect - no weight loss, no hunger suppression. Is this normal?
Hi everyone, I’m 28F with PCOS and BMI around 35, and I’m currently on semaglutide under my endocrinologist’s supervision.
I’ve completed 4 weeks now:
Weeks 1 and 2: 0.25 mg
Week 3: 0.5 mg
Today: 0.5 mg (second 0.5 mg dose)
My doctor plans to increase the dose after this, rather than giving me the originally planned 3 doses of 0.5 mg.
My concern is that I haven't lost even 1 kg or noticed any inch loss, and I don't feel any meaningful hunger suppression. My appetite feels pretty much the same as before.
The only noticeable side effects are usually on the first day after the injection, some nausea/vomiting, but it's manageable with the medication my doctor prescribed. I also get some mild pain/soreness around the injection site on my stomach for a while after the injection. Is that normal?
I know 4 weeks is still early and that 0.25 mg is only a starting dose, but I'm getting worried because I'm not feeling any noticeable effect on appetite or weight.
For people who have been on semaglutide:
Did anyone have almost no appetite suppression or weight loss during the first month?
When did you personally start noticing a meaningful difference?
Did things change significantly when you went from 0.5 mg to higher doses?
Is mild injection-site pain normal?
If you weren't responding initially, what did your doctor do next?
Anything I might be missing?
Would really appreciate experiences, especially from people with PCOS or similar starting weights.