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ANYONE WHO IS CHARGING ANYTHING IN THERE IS NOT ENDORSED BY ME TO DO SO
In light of recent current events in the USA.Here are all the powerful drugs found in Lindsay Clancy’s system after she strangled her three kids SSRIs are becoming more heavily politicized. We need to use this to our advantage. Why do we not send out a mass email to every single U.S Congressman and Senator explaining to them that people are literally chemically castrating themselves and eating shit (fecal matter transplant) in an attempt to cure themselves of a disease caused by SSRIS of which there is absolutely no help for at all and of which no physician will take us seriously for. Of which we have a subreddit that has 18k weekly members 21k subscribers of sufferers.
Are you telling me that if I email 435 congress people and 100 senators that people are fucking castrating themselves to cure themselves of a disease induced by SSRIS of which a lady has already gone public on the White house floor about that not one of them will take action or reply back of which is RIGHT now in the public eye because of the Lindsey Clancey case. it's the perfect time to strike the nation
u/mobius1014 u/moderator u/pssdnetwork can the pssd network accomplish this. If the answer is no project genome will do it in a probably way less sophisticated way than you guys would. Im not taking no for an answer on this.
Yes I am well aware that this information is freely available scattered throughout the void. But when a lot of people say reinstatement they do not specify whether or not they went back on the drug that crashed them or a different drug entirely.
The difference matters because each of these drugs inhibit and induce different clearance enzymes. at different rates.
Hey everyone. Turns out there was a massive flaw with the WAR_POWERS program that I put out a month ago. It was missing a bunch of important heterozygous deletions! I put a lot of work into fixing it fast for you all. Here is the finished product!
As always, the program spits out the raw data. I highly encourage you all to read the raw data with a tsv file viewer and not just what the program spits out so that I can continue to improve it. Let me know if you have any questions. I have pushed the new version to the github repository linked here
Also a photo of Doc Powson because "You gotta castrate to uncastrate"
https://www.reddit.com/r/PSSD/s/Z0UEAzhrxR
The UGT signal is stronger than I thought. My program was flawed and didnt pick up all heterozygous deletions. I am working on fixing it. But when dr powers said “most of these patients lack glucuronidation in some capacity” well I guess he want kidding
CYP2D6 showing up a lot more in us than the general population. Also each one of the androgenic signaling phenotype people have. A major steroid metabolism glitch
Red: same gene different variant
Orange: same variant
Light blue: homozygous deletion
Dark blue: heterozygous deletion
Green: stop gained
Yellow: De novo variant
Purple: same variant + het deletion
Thank you to u/More_Listen for putting all of this data together.
Im working with sequencing.com to confirm the ATP5F1B variant we found is not artifact. Bear with me on that.
I’m currently on a 300mg per week testosterone cycle, and I’ve noticed ALOT of benefits from it in the first couple weeks with libido cognition and anheondia. But not it’s like all of the effects have dissipated, I may even feel worse than I did before while on it. But the weird thing is my body is still responding to androgens very well, I’m putting on size I’m getting stronger etc, so it’s not like PFS where my androgen receptors are working correctly in my muscles. But mentally I feel more brain fog, and I feel more blank minded. Does anyone know why this may be happening?
If Doctor Powers Theory is correct we should have a decent chunk of both of the above. I know we have a decent amount with Osteoperosis. But I am unsure how many are infertile. I looked up on the sub not much info.
On second thought Women too but I cant update the title
None of them give a fuck. For some reason. https://www.reddit.com/r/AskADoctor/s/2CZ9yT49KS
“Hey can you help treat post drug patients?”
FUCK YOU NEEDS AN RCT NEEDS A DOUBLE BLINDED PLACEBO.
Facing jesus level persecution every day. Its fucked
Edit: Medicine Jesus AKA Dr. Powers is not who i am talking about.
Pretty much the title. here you go apple lovers.
My issues with the PSSD organization INIDA. INIDA is a patient led organization that researches PSSD. For those of you who do not know. Recently they launched an autoimmune investigation into GCPR autoantibodies as a diagnostic measure for PSSD via the Cunningham Panel. https://inida.info. The management of the budget, and executive decisions come from patients with little to no experience and that is one of the driving factors on why this is all going wrong.
This was stated in a deleted comment on the pssd subreddit. I know it to be true. It was also stated in the INIDA discord multiple times. My issue with this is, the collecting laboratory for the Cunningham panel is in the USA but we have people using donor money to ship their laboratory samples from over seas. Thats not cheap btw. What sense does that make? Why would we do that? Are you telling me we cant find 30 patients in the USA with PSSD? Im not saying that there was selection bias in this study but it makes me wonder especially when a positive result can result in getting IVIG.
0 Transparency: idk how much I really need to say about this. When is the last time they came out with an update. They also arent transparent about how funds were used.
The Cunningham Panel: we’ve been treating the results of this panel like a diagnostic marker when in reality on multiple occasions healthy controls pop positive on the Cunningham panel and its not even proven as a reliable diagnostic test. To me this seems like a way for Madeline Cunningham to get her test on the market. And she used our donations to do so. https://pmc.ncbi.nlm.nih.gov/articles/PMC6355775/ HOW THE FUCK. Are we going to prove an unproven disease with an unproven test. That is ridiculous. Cunningham wasn’t even at the Pssd pfs world congress. So to me it seems like she doesn’t give a shit about us and she just wants to sell her cunningham panel. Of which she gave us ZERO discount for the study. 1k to run one panel shes raking in that dough. hate to say it but thats what it seems like to me from the outside looking in.
This money would have been better spent on PSSD network or SIDEFXHUB. SIDEFXHUB is currently funding doctor powers research and PSSD network is funding melcangi. SIDEFXHUB is the best out of the two
They blew past their budget. Twice…. And people still donated more. Lol
Im going to get a lot of flak for saying this bu tit needed to be said. No more donations to INIDA.
Edit: I have my issues with Melcangi too. But his research is way more important than what INIDA produced. Sucking down IVIG isnt gonna cure anyone. Not to burst anyones bubble. They had me fooled at first too. Im also of the opinion that their specific area of study is a complete waste of time and not the root cause or a reliable bio marker for pssd. It’s not an autoimmune disorder.
I’m 31 years old now, but I started about 10 years ago in summer of 2016 at 21 when I noticed my crown was thinning, Dr gave me a laser cap, minoxidil and 1mg finasteride, at first, I didn’t really notice anything bad, I knew all the horror stories online, but I still was able to function normally for years in fact,
No sides, lots of nights out with friends, girls, travel and a full head of hair, I figured I was one of the lucky ones, then some of my friends got the idea of doing sarms and I did a cycle in march of 2021 felt like King Kong for about a few weeks and built some nice muscles then … CRASH for about a month and a half. I felt like I was 80 years old, clomid did not seem to help, I recovered after this, but I never felt quite the same, I was more unstable now
Then i believe around early 2022 I stopped finasteride to see if I’d feel better, and man, felt like I was 18 again, I probably did have side effects all along diminishing my libido for all those years however instead of losing half or most of it I probably only lost 10 or 15% so it wasn’t very noticeable at first, who knows tho, but even after being off of it for a long time, I didn’t notice much hair loss
But then I did notice some, and in order to keep my hair I tried topical fin in the summer of 2023, same thing crash, I was down in colombia then and I bought probiotics which seemed to pick me up after I’d take some, along with eating red meat, figured I found the cure to bouncing back quick after stopping it
From that summer onwards, I really couldn’t handle sugar or carbohydrates without some sort of a crash, I continued to take very low dose topical mostly cause of YouTube hair channel’s promoting its safety, early 2025 I stopped, and then tried dutasteride last July. July 2025, crashed hard again but this time it took months to recover, tried topical dut late December 2025 from a doctors advice, and said enough is enough so did a 3 day water fast and ate clean as can be for a month or so and bounced back
Started pyrilutimide 1% this January and I can say it works better than fin like WAY better but I still have sides on and off, it seems as if the crashes are getting longer and harder for me, I often have zero libido, some brain fog, bad sleep, and physically, the testicles are smaller and the volume of semen is watery and “hot” feeling almost, like borderline painful
Wondering if pyrilutimide could also mess up my androgen receptors or if this is just ongoing damage from the dut/fin, I feel I can still recover decently if I go a week eating just meat and avoiding any sugar but this lifestyle is very hard for me to live, as I model, and my hair helps my livelihood in addition so do my muscles so the diet is a big problem
I know there are some here that are probably in way worse shape and I feel for you but just curious if anyone has something to add or experience with pyrilutimide or if anyone tried a libido enhancer like apomorphine
(I’d say I’m 4/10 right now side effects wise and I still get strong morning erections, I never rlly got ED symptoms but low libido absolutely
I know we are all frustrated by the pace of the current research, but an opportunity just opened up that could speed up the data analysis phase.
Anthropic just launched an "AI for Science" grant specifically focused on rare diseases. They are giving away $50,000 in Claude API credits to researchers and patient-led organizations.
If the PFS Network or any independent researchers are currently bogged down in processing data, this could give computational horsepower to automate the heavy lifting.
The deadline is August 2, 2026.
Here is the direct link to the announcement and application:
https://www.anthropic.com/news/rare-disease-research-grants
If anyone here is in direct contact with pfs reserachers, please forward this to them immediately. We need to leverage every tool available.
Developed PSSD after being prescribed Effexor/Venlafaxine for exam stress in college. Spent 7 years trying every supplement, protocol and specialist imaginable trying to fix it. Eventually decided to try TRT properly through a clinic in Thailand after reading success stories online.
Did around 8 months on TRT followed by a full PCT.
TRT improved gym performance, confidence and energy at times, but never truly restored libido or natural sexuality. The entire process ended up being way more psychologically intense than I expected. Hair shedding, agitation, feeling chemically “on”, then a brutal post-PCT crash where I basically slept for 6 weeks straight.
Now months off everything and still trying to get back to baseline.
Posting because there aren’t many detailed TRT → PCT → PSSD experiences online that talk honestly about the mental side of it.
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I’m 30 now.
Around 23 I got prescribed Venlafaxine/Effexor for anxiety/exam stress during college. Honestly at the time it helped a lot mentally, but almost immediately I noticed something felt wrong sexually.
Things became:
I kept bringing it up to my doctor and was constantly told:
I stayed on it around 9 months, came off expecting everything to bounce back, and it never really did.
Over the next 7 years I tried pretty much everything:
Nothing truly fixed it.
Eventually I became convinced the issue had to be hormonal after reading enough TRT/PSSD recovery stories online.
Australian doctors wouldn’t prescribe TRT for PSSD, so I went to Thailand and did it properly through a clinic instead of sourcing random gear online.
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Protocol:
Honestly the first week was rough.
I barely slept for several nights and felt massively overstimulated. Trying to work while sleep deprived and injecting hormones into yourself after years of PSSD anxiety is mentally intense. I was overanalysing every sensation in my body wondering if I’d made a huge mistake.
By week 2 things settled:
Sexually though, nothing major had changed yet.
Dose increased to:
This is where I thought:
>
I started getting:
For the first time in years I felt closer to actual sexuality again.
But the deeper PSSD symptoms still remained underneath it all. Desire improved more than genuine natural arousal/function.
This phase messed with me mentally.
Hair was suddenly everywhere:
I could literally see my temples thinning.
When you already have PSSD and body anxiety, adding possible hair loss into the mix becomes incredibly stressful. I seriously questioned whether any of this was worth it.
The shedding eventually slowed down, but I do think TRT accelerated recession around my hairline thts still kind of noticable even when I have stopped everything.
Physically TRT definitely worked:
But mentally I also changed in ways I didn’t expect.
I felt:
It’s hard to describe but I never fully felt relaxed in my own body on TRT. Almost like there was this constant chemical intensity sitting underneath everything.
Friends/family definitely noticed changes too.
One weird thing:
alcohol started affecting me very differently around this time. I had several blackout drunk nights with almost no memory of what happened which honestly scared me alot .
This was the hardest realisation.
By this point I had to admit:
TRT improved:
But it never restored instinctive sexuality the way I hoped it would.
I also became exhausted by the TRT lifestyle itself:
Eventually I just wanted off.
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I went to an endocrinologist hoping for proper help with PCT.
Honestly it was useless.
The advice was basically:
That started a panic trying to source proper PCT medication.
Eventually I found an online clinic and started:
Later:
The early phase was terrifying.
I lost almost all sexual interest completely. Not just low libido, total disconnection from sexuality. It genuinely made me think I had permanently destroyed myself.
But weirdly emotionally I also started feeling calmer:
Then came coming off everything completely.
This was honestly the hardest phase of the entire journey.
For about 6 weeks my body basically shut down:
It didn’t even feel like emotional depression exactly. More like my nervous system had entered some kind of recovery/reboot mode.
Gradually things improved after that, but it took time.
Months off everything:
The biggest thing TRT taught me is that for me personally, this probably isn’t simply a testosterone problem.
It feels much more:
I don’t fully regret trying TRT because at least now I know.
But I also think people massively underestimate how psychologically intense TRT + PCT can become, especially if you already have PSSD or nervous-system issues.
This was honestly one of the hardest years of my life mentally.
I want to thank the PSSD mods for accepting the criticism that we gave them. A couple months ago there was major concern about over moderation. In which someone made a post criticizing this. Since that time the over-moderation has gotten much much better. Its hard to be accountable and accept criticism but the PSSD mods did and for that I am grateful. I am also grateful they allow open theoretical discussion on this sub