u/burner_struggle101

Okay. I have had chronic ecoli utis my entire life as long as I can remember. I ALWAYS get them after sex or masterbation swimming etc

The drs have thrown Macrobid at me probably every single time and it goes away until the next time I have sex. Even when I was little before I was sexually active id have issues. I never had the urgency and burning I could just always tell by how cloudy my pee was and the smell of my pee. It smelled like death. I’d go to the dr they’d tell me I didn’t have one. I’d say culture it and we’ll see and boom E. coli. Every. Single. Time.

Fast forward to now I had a bad Ureaplasma infection in October 2025 I treated it and my husband did and I’ve been negative since. I feel *way* better than I did. My husband and I test negative for it not long ago and we’re both still negative for plasma.

I will still get flare ups of urinary symptoms though. Always feel worse after sex always feel worse after a shower. But I get vaginal symptoms as well like burning redness irritation.

Does this line up with CUTI? How bad is it? Can you maintain having sex while treating or do you have to abstain forever? What do we do? Please be kind and helpful I struggle bad with OCD & mental health

I read all the posts yeah yeah yeah. Okay but all my microbiome tests are normal my PFPT I’ve been in for 9 months says I’m improving but still tight.

I’ll feel normal for weeks and weeks and then I’ll have a day where I flare and have all of the same symptoms again. Redness burning itching urinary discomfort.

Still test negative. My last evvy looked perfect. Sex alcohol etc seem to trigger my symptoms.

I’m starting to get curious about MCAS? Has anyone had this infection trigger that response? I seem to feel worse the week before my period.

I treated in fall 2025 with 3 weeks doxy 3g azi and my husband did the same. We abstained for 8 weeks both test negative and then had sex. My symptoms didn’t get better with the abx. They only got better once I got rid of my iners but now I still have cyclic symptoms.

My husband and I just both test negative for everything again last week with me getting first morning PCR urine and swab and he got urethra swab and first morning urine. I just don’t see how it could still be Ureaplasma.

Okay October 2025 I treated a ureaplasma parvum infection and ever since it’s been a literal nightmare.

My latest evvy showed 88% lacto crisp 8% iners and the rest was little bits of BV associated bacteria.

My symptoms seem to follow my hormone cycle. The week before my period I’ll feel a little itchy and then I will have full blown UTI symptoms. Burning redness urethra discomfort bladder pain and pressure. It’s always worse after peeing. It’s also worse after anything sexual too. It’s unbearable.

I’m also in pelvic floor therapy. She does say that I’m really tight internally.

I’ll go months with little or no issues and then all of the sudden I’ll have a terrible awful flare. I’m debating like MCAS??

I’m on hydroxyzine 25mg, amitrypiline 25mg HRT estrogen patch and progesterone 10 days a month.

What the fuck guys someone help me please.

Hi everyone. I am looking for some insights or to see if anyone has experienced a similar pattern to mine, as I feel completely stuck and could use some advice on what to look into next. I previously had Ureaplasma parvum, which was treated and cleared. I had comprehensive STI testing, bloodwork, and a Pap smear twelve months after exposure, and my latest first-morning urine PCR was 100% negative for Ureaplasma and Mycoplasma. For additional background, I have a history of Ulcerative Colitis, which is currently in remission, and Primary Ovarian Insufficiency. My POI is managed with a twice-weekly Vivelle-Dot estrogen patch and oral progesterone ten days out of the month to induce a withdrawal bleed. My latest Evvy vaginal microbiome report showed 88% Lactobacillus crispatus dominance.
The confusing part of my condition is that I can go weeks or months with absolutely no issues and feel completely fine, but then I crash into severe, debilitating flares out of nowhere. When I wake up in the morning, I usually feel okay, but immediately after my very first pee of the day, the pain becomes bad bad bad. During a flare, I experience intense, white-hot, UTI-like urinary and urethral burning, but all of my standard urine cultures are always completely negative. I also battle deep bladder pressure, severe post-coital discomfort, intense on-fire tissue pain, and sharp feelings like stabbing knives. On top of that, I get random lightning bolt nerve zaps and electric shock sensations deep inside my vagina.
I have noticed a few major clues regarding what helps and what flares me. Over-the-counter Cystex, which contains an NSAID anti-inflammatory component, usually helps stop the nerve zaps and the burning. I am currently in pelvic floor physical therapy, and my therapist noted that my muscles are extremely tight both internally and externally. I previously tried using compounded vaginal estrogen in a hypoallergenic Ellage base, but every single time I applied it, it made the pain significantly worse. The absolute biggest clue is that my flares always predictably spike right when I change my Vivelle-Dot patch or when I start my ten days of oral progesterone. For medication, I am currently taking Hydroxyzine and recently upped my Amitriptyline dose to 25mg after being on a low 10mg dose for three months.
Because my PCR is completely clear, I know the actual infection is gone, but the pain feels so severe that it makes me panic and worry that it is a hidden bug. Given my autoimmune background with Ulcerative Colitis and the fact that estrogen patch changes and progesterone directly trigger my pain, I am starting to wonder if the Ureaplasma infection triggered localized Mast Cell Activation Syndrome in my pelvis alongside hypertonic pelvic floor spasms. Has anyone with a negative PCR dealt with this kind of cyclical, hormone-triggered nerve pain? Did switching from a twice-weekly estrogen patch to a daily systemic gel help flatten your flares? Has anyone had success adding an H2 blocker like Pepcid to their routine, or using a compounded vaginal Valium or Baclofen suppository to stop the muscle clamping? I would appreciate any advice or shared experiences you can offer. Thank you so much.

Hi everyone. I am looking for some insights or to see if anyone has experienced a similar pattern to mine, as I feel completely stuck and could use some advice on what to look into next. I previously had Ureaplasma parvum, which was treated and cleared. I had comprehensive STI testing, bloodwork, and a Pap smear twelve months after exposure, and my latest first-morning urine PCR was 100% negative for Ureaplasma and Mycoplasma. For additional background, I have a history of Ulcerative Colitis, which is currently in remission, and Primary Ovarian Insufficiency. My POI is managed with a twice-weekly Vivelle-Dot estrogen patch and oral progesterone ten days out of the month to induce a withdrawal bleed. My latest Evvy vaginal microbiome report showed 88% Lactobacillus crispatus dominance.
The confusing part of my condition is that I can go weeks or months with absolutely no issues and feel completely fine, but then I crash into severe, debilitating flares out of nowhere. When I wake up in the morning, I usually feel okay, but immediately after my very first pee of the day, the pain becomes bad bad bad. During a flare, I experience intense, white-hot, UTI-like urinary and urethral burning, but all of my standard urine cultures are always completely negative. I also battle deep bladder pressure, severe post-coital discomfort, intense on-fire tissue pain, and sharp feelings like stabbing knives. On top of that, I get random lightning bolt nerve zaps and electric shock sensations deep inside my vagina.
I have noticed a few major clues regarding what helps and what flares me. Over-the-counter Cystex, which contains an NSAID anti-inflammatory component, usually helps stop the nerve zaps and the burning. I am currently in pelvic floor physical therapy, and my therapist noted that my muscles are extremely tight both internally and externally. I previously tried using compounded vaginal estrogen in a hypoallergenic Ellage base, but every single time I applied it, it made the pain significantly worse. The absolute biggest clue is that my flares always predictably spike right when I change my Vivelle-Dot patch or when I start my ten days of oral progesterone. For medication, I am currently taking Hydroxyzine and recently upped my Amitriptyline dose to 25mg after being on a low 10mg dose for three months.
Because my PCR is completely clear, I know the actual infection is gone, but the pain feels so severe that it makes me panic and worry that it is a hidden bug. Given my autoimmune background with Ulcerative Colitis and the fact that estrogen patch changes and progesterone directly trigger my pain, I am starting to wonder if the Ureaplasma infection triggered localized Mast Cell Activation Syndrome in my pelvis alongside hypertonic pelvic floor spasms. Has anyone with a negative PCR dealt with this kind of cyclical, hormone-triggered nerve pain? Did switching from a twice-weekly estrogen patch to a daily systemic gel help flatten your flares? Has anyone had success adding an H2 blocker like Pepcid to their routine, or using a compounded vaginal Valium or Baclofen suppository to stop the muscle clamping? I would appreciate any advice or shared experiences you can offer. Thank you so much.

Okay October 2025 I treated a ureaplasma parvum infection and ever since it’s been a literal nightmare.

My latest evvy showed 88% lacto crisp 8% iners and the rest was little bits of BV associated bacteria.

My symptoms seem to follow my hormone cycle. The week before my period I’ll feel a little itchy and then I will have full blown UTI symptoms. Burning redness urethra discomfort bladder pain and pressure. It’s always worse after peeing. It’s also worse after anything sexual too. It’s unbearable.

I’m also in pelvic floor therapy. She does say that I’m really tight internally.

I’ll go months with little or no issues and then all of the sudden I’ll have a terrible awful flare. I’m debating like MCAS??

I’m on hydroxyzine 25mg, amitrypiline 25mg HRT estrogen patch and progesterone 10 days a month.

What the fuck guys someone help me please.

Sorry guys. I realize my last post was chaotic.

How did you guys get diagnosed with MCAS vaginally?

I already take 25mg of hydroxyzine daily and not sure that it provides me any relief. If I’m still having flares while taking hydroxyzine does it make it unlikely I would have MCAS?

I had a ureaplasma infection treated in September and since then it’s been one issue after another. I’m negative for everything now and according to my microbiome test EVVY everything looks perfect.

I can’t understand why I’m having episodes of redness burning urethral irritation bladder pain etc when all tests are clear.

How do you get diagnosed with this? If taking 25mg of hydroxyzine daily doesn’t help is it not likely to be MCAS?

If two people are married and only have had sex with each other how would one of them end up with hpv??

Treated and tested negative- wondering if I’m good now or if this could come back. My partner treated also. I’m terrified of symptoms raging back.

Question
16 months ago I had sex with someone of unknown status no sores anywhere or anything

Shortly after I had symptoms and found out I had Ureaplasma- treated that been negative since. The Ureaplasma wreaked havoc on my body and left me with lasting nerve damage I think.

I have never had an outbreak even while being sick stressed and I have 2 autoimmune diseases etc. I’ve had 3 separate negative swabs for HSV. All other STIs negative as of last week and I don’t have any new exposure since my assault.

Sometimes I will get nerve zaps or random tingling feeling but it never amounts to anything.

My dr told me not to test unless I have sores, she said bloodwork is unreliable. I can’t afford the western blot and my mom has HSV1 oral so I wouldn’t be surprised if I’m positive and then I fear I will never know if I have it orally or genitally and the high risk of false negative HSV2 my anxiety can’t handle.

All of that to say- what’re the odds I’ve had HSV for over a year and 0 outbreaks? Wouldn’t the nerve pain eventually lead to symptoms? Would I have had my outbreak by now if I was going to? My Dr said the stress from the assault alone should’ve caused a significant OB. Idk I’m just throwing shit around.

I know blood work isn’t accurate so do we all just go on hoping we don’t have it??

Question
16 months ago I had sex with someone of unknown status no sores anywhere or anything

Shortly after I had symptoms and found out I had Ureaplasma- treated that been negative since. The Ureaplasma wreaked havoc on my body and left me with lasting nerve damage I think.

I have never had an outbreak even while being sick stressed and I have 2 autoimmune diseases etc. I’ve had 3 separate negative swabs for HSV. All other STIs negative as of last week and I don’t have any new exposure since my assault.

Sometimes I will get nerve zaps or random tingling feeling but it never amounts to anything.

My dr told me not to test unless I have sores, she said bloodwork is unreliable. I can’t afford the western blot and my mom has HSV1 oral so I wouldn’t be surprised if I’m positive and then I fear I will never know if I have it orally or genitally and the high risk of false negative HSV2 my anxiety can’t handle.

All of that to say- what’re the odds I’ve had HSV for over a year and 0 outbreaks? Wouldn’t the nerve pain eventually lead to symptoms? Would I have had my outbreak by now if I was going to? My Dr said the stress from the assault alone should’ve caused a significant OB. Idk I’m just throwing shit around. Thanks guys 💙

Question
16 months ago I had sex with someone of unknown status no sores anywhere or anything

Shortly after I had symptoms and found out I had Ureaplasma- treated that been negative since. The Ureaplasma wreaked havoc on my body and left me with lasting nerve damage I think.

I have never had an outbreak even while being sick stressed and I have 2 autoimmune diseases etc. I’ve had 3 separate negative swabs for HSV. All other STIs negative as of last week and I don’t have any new exposure since my assault.

Sometimes I will get nerve zaps or random tingling feeling but it never amounts to anything.

My dr told me not to test unless I have sores, she said bloodwork is unreliable. I can’t afford the western blot and my mom has HSV1 oral so I wouldn’t be surprised if I’m positive and then I fear I will never know if I have it orally or genitally and the high risk of false negative HSV2 my anxiety can’t handle.

All of that to say- what’re the odds I’ve had HSV for over a year and 0 outbreaks? Wouldn’t the nerve pain eventually lead to symptoms? Would I have had my outbreak by now if I was going to? My Dr said the stress from the assault alone should’ve caused a significant OB. Idk I’m just throwing shit around. Thanks guys 💙

Question
16 months ago I had sex with someone of unknown status no sores anywhere or anything

Shortly after I had symptoms and found out I had Ureaplasma- treated that been negative since. The Ureaplasma wreaked havoc on my body and left me with lasting nerve damage I think.

I have never had an outbreak even while being sick stressed and I have 2 autoimmune diseases etc. I’ve had 3 separate negative swabs for HSV. All other STIs negative as of last week and I don’t have any new exposure since my assault.

Sometimes I will get nerve zaps or random tingling feeling but it never amounts to anything.

My dr told me not to test unless I have sores, she said bloodwork is unreliable. I can’t afford the western blot and my mom has HSV1 oral so I wouldn’t be surprised if I’m positive and then I fear I will never know if I have it orally or genitally and the high risk of false negative HSV2 my anxiety can’t handle.

All of that to say- what’re the odds I’ve had HSV for over a year and 0 outbreaks? Wouldn’t the nerve pain eventually lead to symptoms? Would I have had my outbreak by now if I was going to? My Dr said the stress from the assault alone should’ve caused a significant OB. Idk I’m just throwing shit around. Thanks guys 💙

I am pretty sure I possibly have LS. I have other autoimmune issues and low estrogen. I googled it and it looks awful. Is that what is bound to happen if you get an LS diagnosis? I’m fucking terrified. Will I ever be able to have sex or wear jeans again?

I’m trying estrogen cream compounded in ellage base externally only. I’m kinda red and mildly itchy. Is this irritation or can this cream cause a yeast infection? I thought estrogen cream in ellage base was the best option, but are the vaginal tablets better?

Who’s treated ureaplasma with a partner and never had it show back up on tests once negative? Reddit has me scared this is a lifelong STI

Wondering what would cause my estrogen blood level to drop quite a bit while remaining on patches? Has that happened to anybody? What was the cause?