If you use PCSK9i, please be sure to follow these
I am a high volume injectable PCSK9i prescriber. We have a dedicated nursing team that helps with prior auth, patient education etc. So our patient adherence is typically fairly high. Once in a while, we will see patients who stop responding adequately to therapy. We will go through the education again with these patients to make sure they are following all the guidance.
Here are some of the points that we emphasize:
- Rotate injection sites. If you use the same site repeatedly, your medication absorption (and hence efficacy) reduces
- Don't let the medicine freeze
- Don't shake the medicine
- Store at recommended temperature (2 to 8 C). Freezing can cause the drug to be ineffective
- Let it rewarm naturally to room temperature before injecting
Here is what we do when people stop responding:
- Educate and retest in 4 to 8 weeks
- Switch to inclisiran (takes away responsibility from patients since we inject it at our infusion center)
- Try alternative drug class
Here's why I love PCSK9i:
- The effect size is impressive. LDL-C often comes down to around 30
- We have patients who have had repeat CCTA imaging while on PCSK9i and we actually see the plaque burden improve
- Rare side effects, except rhinitis/upper respiratory symptoms for a day or two
Here are my questions for you:
- If you stopped responding to PCSK9i, I would be interested in learning about your experience.
- Have you noticed your LDL-C levels creep up after using it for years?
The lack of real world evidence/tracking is inconvenient. Are there any websites that help pool/track data? I am starting to prescribe Lerochol and Lipfendra. I would love to be able to see how people are responding to these.